2-Ethyl-1-phenylpiperazine | 893750-52-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 2-Ethyl-1-phenylpiperazine
• CAS: 893750-52-2
• 化学式: C₁₂H₁₈N₂
• 分子量: 190.28
• InChiKey: FDLFJMALQUAPDM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  15.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-溴噻唑-5-甲酸甲酯 、 2-Ethyl-1-phenylpiperazine 、 potassium carbonate 在 氮气 作用下， 以 乙腈 为溶剂， 反应 10.0h， 以to give the compound 15c (245 mg, 66.4%)的产率得到2-[4-(2-hydroxyethyl)-piperazin-1-yl]-thiazole-5-carboxylic acid methyl ester
  参考文献：
  名称：

  INHIBITORS OF HISTONE DEACETYLASE

  摘要：

  本发明涉及一种抑制组蛋白去乙酰化酶（HDAC）酶活性的化合物。还涉及包含这些化合物的制药组合物以及治疗至少部分由HDAC介导的疾病状态，特别是增殖性疾病状态的方法。

  公开号：

  US20080139535A1

文献信息

• [EN] NICOTINIC ACETYLCHOLINE RECEPTOR SILENT AGONISTS<br/>[FR] AGONISTES SILENCIEUX DU RÉCEPTEUR NICOTINIQUE D'ACÉTYLCHOLINE
  申请人：THE UNIV OF FLORIDA RES FOUND INC

  公开号：WO2017066558A1

  公开（公告）日：2017-04-20

  Derivatives of N,N-diethyl-N'- phenyl-piperazine, a silent agonist of the mammalian α7 nicotinic acetylcholine receptor, are provided. These silent agonists control the desensitization state of the receptor. Further provided are pharmaceutical compositions that allow the administration of the silent agonists of the disclosure to a subject animal or human in need of treatment for a pathological condition arising from such as inflammation. The novel silent agonists also may be co-administered to a patient simultaneously or consecutively with a type II positive allosteric modulator to modulate the activity of the receptor.

  N,N-二乙基-N'-苯基哌嗪的衍生物，作为哺乳动物α7尼古丁乙酰胆碱受体的沉默激动剂，已提供。这些沉默激动剂控制受体的耗散状态。还提供了允许将上述沉默激动剂给予需要治疗由炎症等病理状况引起的动物或人类的药物组合物。这种新型沉默激动剂也可以与II型正向变构调节剂同时或连续给予患者，以调节受体的活性。
• PHENYL AMINO PIPERIDINE mTORC INHIBITORS AND USES THEREOF
  申请人：Navitor Pharmaceuticals, Inc.

  公开号：US20180127370A1

  公开（公告）日：2018-05-10

  The present invention provides compounds, compositions thereof, and methods of using the same.

  本发明提供了化合物、其组合物以及使用它们的方法。
• [EN] 3-CYANOQUINOLINES,3-CYANO-1,6-NAPHTHYRIDINES, AND 3-CYANO-1,7-NAPHTHYRIDINES AS PROTEIN KINASE INHIBITORS<br/>[FR] 3-CYANOQUINOLINES,3-CYANO-1,6-NAPHTHYRIDINES ET 3-CYANO-1,7-NAPHTHYRIDINES UTILISEES COMME INHIBITEURS DE PROTEINEKINASE
  申请人：AMERICAN HOME PROD

  公开号：WO2001072711A1

  公开（公告）日：2001-10-04

  Compounds of Formula (I), having the structure or a pharmaceutically salt thereof are useful as antineoplastic agents and in the treatment of osteoporosis and polycystic kidney disease.

  具有结构式（I）或其药物盐的化合物在抗肿瘤药物和治疗骨质疏松症和多囊肾病方面是有用的。
• Inhibitors of histone deacetylase
  申请人：Anandan K. Sampath

  公开号：US20050250784A1

  公开（公告）日：2005-11-10

  Disclosed are compounds which inhibit histone deacetylase (HDAC) enzymatic activity. Also disclosed are pharmaceutical compositions comprising such compounds as well as methods to treat conditions, particularly proliferative conditions, mediated at least in part by HDAC.

  本发明公开了抑制组蛋白去乙酰化酶（HDAC）酶活性的化合物。本发明还公开了包含这些化合物的药物组合物，以及治疗至少部分由HDAC介导的疾病，特别是增殖性疾病的方法。
• Nicotinic acetylcholine receptor silent agonists
  申请人：University of Florida Research Foundation, Inc.

  公开号：US10662191B2

  公开（公告）日：2020-05-26

  Derivatives of N,N-diethyl-N′-phenyl-piperazine, a silent agonist of the mammalian α7 nicotinic acetylcholine receptor, are provided. These silent agonists control the desensitization state of the receptor. Further provided are pharmaceutical compositions that allow the administration of the silent agonists of the disclosure to a subject animal or human in need of treatment for a pathological condition arising from such as inflammation. The novel silent agonists also may be co-administered to a patient simultaneously or consecutively with a type II positive allosteric modulator to modulate the activity of the receptor.

  本研究提供了哺乳动物 α7 尼古丁乙酰胆碱受体的沉默激动剂 N,N-二乙基-N′-苯基哌嗪的衍生物。这些沉默激动剂可控制受体的脱敏状态。此外，还提供了药物组合物，可将本公开的沉默激动剂施用给需要治疗炎症等病理状况的动物或人。新型沉默激动剂还可与 II 型正性异位调节剂同时或连续给患者用药，以调节受体的活性。