4-[(3-carboxy-2-hydroxy-naphthalen-1-yl)methyl]-3-hydroxy-naphthalene-2-carboxylic acid; 2-(N,N-dimethylcarbamimidoyl)guanidine | 34461-22-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 4-[(3-carboxy-2-hydroxy-naphthalen-1-yl)methyl]-3-hydroxy-naphthalene-2-carboxylic acid; 2-(N,N-dimethylcarbamimidoyl)guanidine
• 英文别名: 4-[(3-carboxy-2-hydroxynaphthalen-1-yl)methyl]-3-hydroxynaphthalene-2-carboxylic acid;3-(diaminomethylidene)-1,1-dimethylguanidine
• CAS: 34461-22-8
• 化学式: C27H27N5O6
• 分子量: 517.5
• InChiKey: MBRKWIDGYNJPOT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.15
• 重原子数：
  38
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  207
• 氢给体数：
  7
• 氢受体数：
  7

文献信息

• Methods and compositions for the treatment of alopecia and other disorders of the pilosebaceous apparatus
  申请人：Orentreich Foundation for the Advancement of Science, Inc.

  公开号：US20020143039A1

  公开（公告）日：2002-10-03

  Insulin sensitivity increasing substances (ISIS), including but not limited to D-chiro-inositol, thiazolidinedione and derivatives, and biguanides, are useful in the treatment of hair loss and other disorders of the pilosebaceous apparatus (hirsutism, acne, etc.) associated with conditions of excess insulin and/or insulin resistance. The treatment comprises administering to a mammal, such as a human, at least one ISIS either alone or in combination with at least one agent, such as an androgen receptor blocker (ARB) and/or a steroid enzyme inhibitor or inducer (STI). Additionally, an activity enhancing agent may be included for topical administration.

  胰岛素敏感性增加物质（ISIS），包括但不限于D-螺肌醇、噻唑烷二酮及其衍生物和双胍类，可用于治疗与胰岛素过量和/或胰岛素抵抗相关的脱发和其他皮脂腺疾病（多毛症、痤疮等）。治疗方法包括向哺乳动物（如人类）施用至少一种 ISIS，可以单独施用，也可以与至少一种制剂（如雄激素受体阻断剂（ARB）和/或类固醇酶抑制剂或诱导剂（STI））联合施用。此外，还可加入一种活性增强剂，用于局部给药。
• USE OF INSULIN SENSITIVITY INCREASING SUBSTANCES FOR THE TREATMENT OF ALOPECIA
  申请人：Orentreich Foundation for the Advancement of Science, Inc.

  公开号：EP1267850B1

  公开（公告）日：2007-04-11
• COMPOSITIONS FOR THE TREATMENT OF ALOPECIA AND OTHER DISORDERS OF THE PILOSEBACEOUS APPARATUS
  申请人：Orentreich Foundation for the Advancement of Science, Inc.

  公开号：EP1267850A2

  公开（公告）日：2003-01-02
• Methods and Compositions for the Treatment of Alopecia and Other Disorders of the Pilosebaceous Apparatus
  申请人：Krajcik A. Rozlyn

  公开号：US20070066661A1

  公开（公告）日：2007-03-22

  Insulin sensitivity increasing substances (ISIS), including but not limited to D-chiro-inositol, thiazolidinedione and derivatives, and biguanides, are useful in the treatment of hair loss and other disorders of the pilosebaceous apparatus (hirsutism, acne, etc.) associated with conditions of excess insulin and/or insulin resistance. The treatment comprises administering to a mammal, such as a human, at least one ISIS either alone or in combination with at least one agent, such as an androgen receptor blocker (ARB) and/or a steroid enzyme inhibitor or inducer (STI). Additionally, an activity enhancing agent may be included for topical administration.
• METFORMIN AMINO ACID COMPOUNDS AND METHODS OF USING THE SAME
  申请人：Laboratorios Silanes S.A. DE C.V.

  公开号：US20200222343A1

  公开（公告）日：2020-07-16

  The present invention relates to metformin amino acid compounds (SLNs), pharmaceutical compositions thereof, and methods of using them for the treatment of hyperglycemia, diabetes, and Type 2 diabetes. The compounds can be synthesized using the processes disclosed herein.