3-[4-(cyclopropylmethoxy)phenyl]propanoic acid | 1047680-56-7

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 苯丙酸
• 英文名称: 3-[4-(cyclopropylmethoxy)phenyl]propanoic acid
• CAS: 1047680-56-7
• 化学式: C₁₃H₁₆O₃
• 分子量: 220.268
• InChiKey: PIGOSVBIKWKLOF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  16
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  对羟基苯丙酸甲酯 在 sodium hydroxide 、 水 、 potassium carbonate 作用下， 以 甲醇 、 丁酮 为溶剂， 反应 18.5h， 生成 3-[4-(cyclopropylmethoxy)phenyl]propanoic acid
  参考文献：
  名称：

  WO2008/101240

  摘要：

  公开号：

文献信息

• COMPOUNDS HAVING A CYCLIC MOIETY AND COMPOSITIONS FOR DELIVERING ACTIVE AGENTS
  申请人：Tang Pingwah

  公开号：US20100074861A1

  公开（公告）日：2010-03-25

  Compounds comprising cyclic moiety and compositions for the delivery of active agents are provided. Methods of administration and preparation are provided as well.

  本发明提供了由环状基团组成的化合物和用于传递活性剂的组合物。同时也提供了其管理和制备方法。
• Compounds having a cyclic moiety and compositions for delivering active agents
  申请人：Tang Pingwah

  公开号：US08383852B2

  公开（公告）日：2013-02-26

  Compounds comprising cyclic moiety and compositions for the delivery of active agents are provided. Methods of administration and preparation are provided as well.

  本发明提供了包含环状基团的化合物和用于传递活性剂的组合物。同时还提供了用于管理和制备的方法。
• COMPOSITIONS OF PENTOSAN POLYSULFATE SALTS FOR ORAL ADMINISTRATION AND METHODS OF USE
  申请人：Urigen Pharmaceuticals, Inc.

  公开号：EP3110427A1

  公开（公告）日：2017-01-04
• COMPOSITIONS AND METHODS FOR TREATMENT OF DISEASES AND CONDITIONS EMPLOYING ORAL ADMINISTRATION OF SODIUM PENTOSAN POLYSULFATE AND OTHER PENTOSAN POLYSULFATE SALTS
  申请人：PARSONS C. Lowell

  公开号：US20170189443A1

  公开（公告）日：2017-07-06

  The present invention is directed to a pharmaceutical composition comprising: (1) a therapeutically effective quantity of sodium pentosan polysulfate; (2) a quantity of a penetration enhancer sufficient to improve the bioavailability of the sodium pentosan polysulfate; and (3) optionally, a pharmaceutically acceptable carrier and to methods for the oral administration of sodium pentosan polysulfate with improved bioavailability for the treatment of interstitial cystitis and other urinary tract diseases and conditions. Such compositions and methods allow the administration of sodium pentosan polysulfate at lower dosages to reduce the frequency and severity of side effects.
• US8383852B2
  申请人：——

  公开号：US8383852B2

  公开（公告）日：2013-02-26