1-chloro-1,1,3,3-tetraisopropyl-3-[2-(triphenylmethoxy)ethoxy]disiloxane | 207982-96-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: 1-chloro-1,1,3,3-tetraisopropyl-3-[2-(triphenylmethoxy)ethoxy]disiloxane
• 英文别名: Chloro-[di(propan-2-yl)-(2-trityloxyethoxy)silyl]oxy-di(propan-2-yl)silane；chloro-[di(propan-2-yl)-(2-trityloxyethoxy)silyl]oxy-di(propan-2-yl)silane
• CAS: 207982-96-5
• 化学式: C₃₃H₄₇ClO₃Si₂
• 分子量: 583.358
• InChiKey: ZLNBALMWPXYNGV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  9.79
• 重原子数：
  39
• 可旋转键数：
  14
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  27.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1-chloro-1,1,3,3-tetraisopropyl-3-[2-(triphenylmethoxy)ethoxy]disiloxane 、 beta-胸苷 在 吡啶 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 以90%的产率得到1-[(2R,4S,5R)-5-[[[di(propan-2-yl)-(2-trityloxyethoxy)silyl]oxy-di(propan-2-yl)silyl]oxymethyl]-4-hydroxyoxolan-2-yl]-5-methylpyrimidine-2,4-dione
  参考文献：
  名称：

  1, 1, 3, 3-Tetraisopropyl-3-(2-(triphenylmethoxy)ethoxy)disiloxane-1-yl group, a potential 5′-O-protecting group for solid-phase RNA synthesis

  摘要：

  1, 1, 3, 3-Tetraisopropyl-3-(2-(triphenylmethoxy)ethoxy)disiloxane-1-yl (TES) group was designed for solid-phase RNA synthesis as a 5'-O-protecting group, which can be combined with the tetrahydropyranyl group, a 2'-hydroxyl protecting group. The TES group can be selectively introduced to the 5'-hydroxy group of nucleosides and can be easily removed by 0.1M tetrabutylammonium fluoride or 0.01M hydrochloric acid. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(98)00440-7
• 作为产物：
  描述：

  1,3二氯-1,1,3,3-四异丙基二硅氧烷 、 一甘醇单三苯甲基醚 在 咪唑 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 2.0h， 生成 1-chloro-1,1,3,3-tetraisopropyl-3-[2-(triphenylmethoxy)ethoxy]disiloxane
  参考文献：
  名称：

  1, 1, 3, 3-Tetraisopropyl-3-(2-(triphenylmethoxy)ethoxy)disiloxane-1-yl group, a potential 5′-O-protecting group for solid-phase RNA synthesis

  摘要：

  1, 1, 3, 3-Tetraisopropyl-3-(2-(triphenylmethoxy)ethoxy)disiloxane-1-yl (TES) group was designed for solid-phase RNA synthesis as a 5'-O-protecting group, which can be combined with the tetrahydropyranyl group, a 2'-hydroxyl protecting group. The TES group can be selectively introduced to the 5'-hydroxy group of nucleosides and can be easily removed by 0.1M tetrabutylammonium fluoride or 0.01M hydrochloric acid. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(98)00440-7

文献信息

• 1, 1, 3, 3-Tetraisopropyl-3-(2-(triphenylmethoxy)ethoxy)disiloxane-1-yl group, a potential 5′-O-protecting group for solid-phase RNA synthesis
  作者：Ichiro Hirao、Masahiro Koizumi、Yoshiharu Ishido、Alex Andrus

  DOI：10.1016/s0040-4039(98)00440-7

  日期：1998.5

  1, 1, 3, 3-Tetraisopropyl-3-(2-(triphenylmethoxy)ethoxy)disiloxane-1-yl (TES) group was designed for solid-phase RNA synthesis as a 5'-O-protecting group, which can be combined with the tetrahydropyranyl group, a 2'-hydroxyl protecting group. The TES group can be selectively introduced to the 5'-hydroxy group of nucleosides and can be easily removed by 0.1M tetrabutylammonium fluoride or 0.01M hydrochloric acid. (C) 1998 Elsevier Science Ltd. All rights reserved.