1.4-Bis-(2-mercapto-ethyl)-piperazin | 14970-81-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 1.4-Bis-(2-mercapto-ethyl)-piperazin
• 英文别名: 2,2'-(Piperazine-1,4-diyl)diethanethiol；2-[4-(2-sulfanylethyl)piperazin-1-yl]ethanethiol
• CAS: 14970-81-1
• 化学式: C₈H₁₈N₂S₂
• 分子量: 206.376
• InChiKey: SYPJZNPUWFMUFU-UHFFFAOYSA-N

物化性质

• 沸点：
  96 °C(Press: 0.03 Torr)
• 密度：
  1.075±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  12
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  8.5
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  bis(acetylacetonate)nickel(II) 、 1.4-Bis-(2-mercapto-ethyl)-piperazin 以 甲苯 为溶剂， 反应 1.0h， 以66%的产率得到(bismercaptoethanediazacyclooctane)nickel(II)
  参考文献：
  名称：

  离散的空气稳定的镍（II）–钯（II）配合物作为Suzuki–Miyaura反应的催化剂

  摘要：

  Four novel bidentate phosphine-Pd complexes coordinated by NiN2S2 metallodithiolate ligands were synthesized and characterized, including XRD analysis; these redox-active complexes are stable in air, and they survive column chromatography on silica gel. The Ni-Pd bimetallic complexes are demonstrated to be precatalyst for Suzuki-Miyaura cross-coupling reactions. The best of these has an overall yield of over 99% under only 1% catalyst loading. The role of NiN2S2 as a stabilizing bidentate ligand, that is also oxidizable may account for its efficacy in the support of the catalysis.

  DOI：

  10.1021/acs.organomet.7b00176
• 作为产物：
  描述：

  环硫乙烷 、 哌嗪 以 苯 为溶剂， 反应 48.0h， 以85%的产率得到1.4-Bis-(2-mercapto-ethyl)-piperazin
  参考文献：
  名称：

  Pinwheel motifs: formation of unusual homo- and hetero-nuclear aggregates via bridging thiolates

  摘要：

  同源六核络合物 [Ni2{Ni(L1)}4](BF4)4·MeCN，标记为1，[Pd2{Pd(L2)}4](BF4)4，标记为2，以及异源五核聚集体 [Cu2{Ni(L3)}3](PF6)2，标记为3，均通过硫醇桥接形成“风车”型结构模式，分别在平面正方形的Ni(II)或Pd(II)和三角平面的Cu(I)中心之间。

  DOI：

  10.1039/b303851c

文献信息

• US4618599A
  申请人：——

  公开号：US4618599A

  公开（公告）日：1986-10-21
• US7179794B2
  申请人：——

  公开号：US7179794B2

  公开（公告）日：2007-02-20
• [EN] "GOOD"BUFFER-BASED CATIONIC LIPIDS<br/>[FR] "BONS" LIPIDES CATIONIQUES À BASE DE SUBSTANCE TAMPON
  申请人：[en]TRANSLATE BIO, INC.

  公开号：WO2022221688A1

  公开（公告）日：2022-10-20

  The present invention provides, among other things, a novel class of cationic lipid compounds (e.g., cationic lipids having a structure according to Formula (I)) forin vivodelivery of therapeutic agents, such as nucleic acids. It is contemplated that these compounds are capable of highly effectivein vivodelivery while maintaining a favorable toxicity profile.
• Pinwheel motifs: formation of unusual homo- and hetero-nuclear aggregates via bridging thiolates
  作者：Angelo J. Amoroso、Simon S. M. Chung、Douglas J. E. Spencer、Jonathan P. Danks、Mark W. Glenny、Alexander J. Blake、Paul A. Cooke、Claire Wilson、Martin Schröder

  DOI：10.1039/b303851c

  日期：——

  The homohexanuclear complexes [Ni2Ni(L1)}4](BF4)4·MeCN, 1, [Pd2Pd(L2)}4](BF4)4, 2, and the heteropentanuclear aggregate [Cu2Ni(L3)}3](PF6)2, 3, all adopt a ‘pinwheel’ type structural motif via thiolate bridging between square-planar Ni(II) or Pd(II) and between trigonal planar Cu(I) centres, respectively.

  同源六核络合物 [Ni2Ni(L1)}4](BF4)4·MeCN，标记为1，[Pd2Pd(L2)}4](BF4)4，标记为2，以及异源五核聚集体 [Cu2Ni(L3)}3](PF6)2，标记为3，均通过硫醇桥接形成“风车”型结构模式，分别在平面正方形的Ni(II)或Pd(II)和三角平面的Cu(I)中心之间。
• Discrete Air-Stable Nickel(II)–Palladium(II) Complexes as Catalysts for Suzuki–Miyaura Reactions
  作者：Tiankun Zhao、Pokhraj Ghosh、Zachary Martinez、Xufeng Liu、Xianggao Meng、Marcetta Y. Darensbourg

  DOI：10.1021/acs.organomet.7b00176

  日期：2017.5.8

  Four novel bidentate phosphine-Pd complexes coordinated by NiN2S2 metallodithiolate ligands were synthesized and characterized, including XRD analysis; these redox-active complexes are stable in air, and they survive column chromatography on silica gel. The Ni-Pd bimetallic complexes are demonstrated to be precatalyst for Suzuki-Miyaura cross-coupling reactions. The best of these has an overall yield of over 99% under only 1% catalyst loading. The role of NiN2S2 as a stabilizing bidentate ligand, that is also oxidizable may account for its efficacy in the support of the catalysis.