tetrahydrocannabinolic acid | 23978-89-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: tetrahydrocannabinolic acid
• 英文别名: Δ³-Tetrahydrocannabinolsaeure；Δ8-THC-2-carboxylic acid；delta-8-Tetrahydrocannabinolic acid；(6aR,10aR)-1-hydroxy-6,6,9-trimethyl-3-pentyl-6a,7,10,10a-tetrahydrobenzo[c]chromene-2-carboxylic acid
• CAS: 23978-89-4
• 化学式: C₂₂H₃₀O₄
• 分子量: 358.478
• InChiKey: YKKHSYLGQXKVMO-HZPDHXFCSA-N

物化性质

• 沸点：
  429.9±45.0 °C(Predicted)
• 密度：
  1.112±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.8
• 重原子数：
  26
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.59
• 拓扑面积：
  66.8
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  四氢大麻酚酸 在 水 作用下， 40.0 ℃ 、101.33 kPa 条件下， 反应 4383.0h， 生成 tetrahydrocannabinolic acid 、 大麻酚 、 (-)-Δ8-四氢大麻酚 、 四氢大麻酚
  参考文献：
  名称：

  WO2008/134668

  摘要：

  公开号：

文献信息

• Cannabinoid composition and products including α-tocopherol
  申请人：Constance Therapeutics, Inc.

  公开号：US10238745B2

  公开（公告）日：2019-03-26

  A cannabinoid composition having an excipient including α-tocopherol and at least one isolated cannabinoid having a purity of greater than 80%. The α-tocopherol inhibits oxidation, regulates viscosity of the composition, and improves bioavailability of the cannabinoid. The composition includes a carrier oil mixed with the excipient and cannabinoid. In one embodiment, the at least one cannabinoid is an isolated cannabinoid having a greater than 80% purity, and preferably greater than 90% purity. The at least one cannabinoid is selected from the group consisting of phytocannabinoids, endocannabinoids, synthetic cannabinoids, and combinations thereof. The cannabinoid may be derived from plants other than cannabis sativa, or synthesized from fungi, bacteria, yeast or other synthetic method. Preferably the α-tocopherol comprises at least 10% w/w of the composition.

  一种大麻素组合物，其赋形剂包括α-生育酚和至少一种纯度大于 80% 的分离大麻素。α-生育酚可抑制氧化，调节组合物的粘度，提高大麻素的生物利用度。组合物包括与赋形剂和大麻素混合的载体油。在一个实施方案中，至少一种大麻素是分离出来的大麻素，纯度大于 80%，最好大于 90%。至少一种大麻素选自植物大麻素、内源性大麻素、合成大麻素及其组合组成的组。大麻素可以从大麻以外的植物中提取，也可以从真菌、细菌、酵母或其他合成方法中合成。α-生育酚最好至少占组合物重量的 10%。
• Cannabis oil extracts and compositions
  申请人：CONSTANCE THERAPEUTICS, INC.

  公开号：US10406186B2

  公开（公告）日：2019-09-10

  The present invention provides cannabis oil extracts and compositions thereof, including cannabis oil compositions containing vitamin E, and methods for preparing the extracts and compositions. In some embodiments, the present invention provides a method for preparing a cannabis oil extract comprising eluting cannabinoids from cannabis plant material with a solvent to produce an eluate, filtering the eluate with a filter to produce a filtrate, evaporating the solvent from the filtrate with a distiller to produce a distillate, and purging the distillate under conditions sufficient to remove residual solvent, thereby preparing the extract. In some embodiments, the method further includes mixing a quantity of vitamin E with the extract to produce a cannabis oil composition.

  本发明提供了大麻油提取物及其组合物，包括含有维生素 E 的大麻油组合物，以及制备提取物和组合物的方法。在一些实施方案中，本发明提供了一种制备大麻油提取物的方法，包括用溶剂从大麻植物材料中洗脱大麻素以产生洗脱液，用过滤器过滤洗脱液以产生滤液，用蒸馏器蒸发滤液中的溶剂以产生蒸馏物，在足以除去残留溶剂的条件下净化蒸馏物，从而制备提取物。在某些实施方案中，该方法还包括将一定量的维生素 E 与萃取物混合，制成大麻油组合物。
• Breeding, production, processing and use of medical cannabis
  申请人：BIOTECH INSTITUTE, LLC

  公开号：US10441617B2

  公开（公告）日：2019-10-15

  The invention provides compositions and methods for the breeding, production, processing and use of medical cannabis.

  本发明提供了用于培育、生产、加工和使用医用大麻的组合物和方法。
• Bioactive concentrates and uses thereof
  申请人：SC LABORATORIES, INC.

  公开号：US10792318B2

  公开（公告）日：2020-10-06

  The present invention relates to concentrates obtained from extraction from Cannabis, preferably cannabinoid and/or terpene concentrates, and formulation of the concentrates, particularly for use for direct vaporization, infusion into edible matrices, in electronic inhalation devices, and as nutraceuticals.

  本发明涉及从大麻中提取的浓缩物，最好是大麻素和/或萜类浓缩物，以及浓缩物的配方，特别是用于直接汽化、注入可食用基质、电子吸入装置和作为营养保健品。
• Biosynthesis of cannabinoids and cannabinoid precursors
  申请人：Ginkgo Bioworks, Inc.

  公开号：US11274320B2

  公开（公告）日：2022-03-15

  Aspects of the disclosure relate to biosynthesis of cannabinoids and cannabinoid precursors in recombinant cells and in vitro.

  本公开的各个方面涉及在重组细胞和体外进行大麻素和大麻素前体的生物合成。