毒理性
◉ 母乳喂养期间使用总结：目前没有关于在哺乳期间使用格雷司琼的信息。在获得更多信息之前，哺乳期间应谨慎使用格雷司琼。可能更倾向于使用另一种药物。
◉ 对哺乳婴儿的影响：截至修订日期，没有找到相关的已发布信息。
◉ 对泌乳和母乳的影响：一位正在给一个8个月大婴儿哺乳的母亲，每天6到8次，因阑尾炎入院接受手术。在手术过程中，她接受了格雷司琼、头孢唑林、酮咯酸、罗库溴铵、琥珀胆碱和舒芬太尼。患者还接受了两次静脉注射丙泊酚150毫克，随后不久又注射了50毫克。术后，她接受了对乙酰氨基酚、头孢唑林、布洛芬和泮托拉唑，以及按需使用的氧可酮和晕海宁。手术22小时后，母亲第一次挤出乳汁，发现乳汁呈浅绿色。使用未经验证的分析方法对绿色乳汁进行分析，未检测到丙泊酚。绿色在术后第4天消失，当她恢复哺乳时。作者判断，绿色可能是由于丙泊酚或其代谢物引起的。
◉ Summary of Use during Lactation:No information is available on the use of granisetron during breastfeeding. Until more data become available, granisetron should be used with caution during breastfeeding. An alternate drug may be preferred.
◉ Effects in Breastfed Infants:Relevant published information was not found as of the revision date.
◉ Effects on Lactation and Breastmilk:A woman nursing an 8-month-old infant 6 to 8 times daily was admitted to the hospital for an appendectomy. During the procedure she received granisetron, cefazolin, ketorolac, rocuronium, succinylcholine, and sufentanil. The patient also received 2 boluses of intravenous propofol of 150 mg followed shortly thereafter by a 50 mg dose. Postoperatively, she was receiving acetaminophen, cefazolin, ibuprofen, and pantoprazole, as well as oxycodone and dimenhydrinate as needed. Twenty-two hours after the procedure, the mother extracted milk for the first time and noted it to be light green in color. Analysis of the green milk using a nonvalidated assay detected no propofol. The green color faded and was absent by postoperative day 4 when she resumed breastfeeding. The authors judged that the green color was possibly caused by propofol or one of its metabolites.
来源:Drugs and Lactation Database (LactMed)
