| 93805-26-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• CAS: 93805-26-6
• 化学式: C10H8NaO4S
• 分子量: 247.22
• InChiKey: QPMSKPRIVIXTRX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.41
• 重原子数：
  16
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  83
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• [EN] SUBSTITUTED SULFONAMIDES USEFUL AS ANTIAPOPTOTIC BCL INHIBITORS<br/>[FR] SULFONAMIDES SUBSTITUÉS UTILES COMME INHIBITEURS DE BCL ANTI-APOPTOTIQUES
  申请人：BRISTOL MYERS SQUIBB CO

  公开号：WO2012162365A1

  公开（公告）日：2012-11-29

  Disclosed are compounds of Formula (I), or a pharmaceutically acceptable salt thereof, wherein: W and Q and G are defined herein. Also disclosed are methods of using such compounds as inhibitors of Bcl-2 family antiapoptotic proteins for the treatment of cancer; and pharmaceutical compositions comprising such compounds.

  揭示了式（I）的化合物或其药学上可接受的盐，其中：W、Q和G在此处被定义。还揭示了将这些化合物用作Bcl-2家族抗凋亡蛋白的抑制剂以治疗癌症的方法；以及包含这些化合物的药物组合物。
• SUBSTITUTED SULFONAMIDES USEFUL AS ANTIAPOPTOTIC BCL INHIBITORS
  申请人：Borzilleri Robert M.

  公开号：US20140135318A1

  公开（公告）日：2014-05-15

  Disclosed are compounds of Formula (I), or a pharmaceutically acceptable salt thereof, wherein: W and Q and G are defined herein. Also disclosed are methods of using such compounds as inhibitors of Bcl-2 family antiapoptotic proteins for the treatment of cancer; and pharmaceutical compositions comprising such compounds.

  本发明涉及式（I）的化合物或其药学上可接受的盐，其中：W、Q和G的定义如下。还公开了使用这些化合物作为Bcl-2家族抗凋亡蛋白的抑制剂用于治疗癌症的方法；以及包含这些化合物的药物组合物。
• Process for the preparation of polyester, and its composition
  申请人：POLYPLASTICS CO. LTD.

  公开号：EP0517511A2

  公开（公告）日：1992-12-09

  The present invention provides a process for the preparation of a polyester which has a high rate of crystallisation and is excellent not only in the processability in moulding but also in heat resistance and mechanical strengths. In the preparation of an aromatic polyester by the reaction of a lower alkyl ester of an aromatic dicarboxylic acid with an aliphatic diol, the transesterification of the lower alkyl ester with the diol is conducted in the presence of 0.02 to 5.0 mole %, based on the lower alkyl ester of an aromatic dicarboxylic acid, of an aromatic sulfonic acid compound represented by the following general formula (I) by the use of a titanium compound as a catalyst, followed by the polycondensation of the transesterification product:         HO-R-O-Ar-SO₃M   (I)    wherein -Ar- is a group selected between p-substituted benzene and 2,6-substituted naphthalene groups;    R is a divalent group selected from among -CH₂CH₂-, -CH(CH₃)CH₂-, -CH₂CH(CH₃)- and -CH₂CH₂OCH₂CH₂-;    and M is an alkali metal selected from among lithium, sodium and potassium. An excellent composition comprising this polyester and other aromatic polyester can be obtained.

  本发明提供了一种制备聚酯的工艺，这种聚酯具有很高的结晶率，不仅在模塑加工性方面，而且在耐热性和机械强度方面都非常出色。 在通过芳香族二羧酸的低级烷基酯与脂肪族二元醇反应制备芳香族聚酯时，以芳香族二羧酸的低级烷基酯为基准，在 0.02 至 5.0 摩尔%的芳香族磺酸化合物存在下，使用钛化合物作为催化剂，进行低级烷基酯与二元醇的酯交换反应，然后对酯交换反应产物进行缩聚反应： HO-R-O-Ar-SO₃M (I) 其中 -Ar- 是选自对取代苯和 2,6-取代萘的基团； R 是选自 -CH₂CH₂-、-CH(CH₃)CH₂-、-CH₂CH(CH₃)- 和 -CH₂CH₂OCH₂CH₂- 的二价基团； 和 M 是选自锂、钠和钾的碱金属。 由这种聚酯和其他芳香族聚酯组成的组合物效果极佳。
• US5302690A
  申请人：——

  公开号：US5302690A

  公开（公告）日：1994-04-12
• US9346795B2
  申请人：——

  公开号：US9346795B2

  公开（公告）日：2016-05-24