cleomiscosin A | 1137653-03-2

• 分子结构分类: 有机化合物 - 木脂素、新木脂素和相关化合物 - 香豆素木脂素
• 英文名称: cleomiscosin A
• 英文别名: cleomiscosin B；cleomiscosin C；9H-Pyrano(2,3-f)-1,4-benzodioxin-9-one, 2,3-dihydro-2-(4-hydroxy-3-methoxyphenyl)-3-(hydroxymethyl)-5-methoxy-, trans-(+-)-；(2S,3S)-2-(4-hydroxy-3-methoxyphenyl)-3-(hydroxymethyl)-5-methoxy-2,3-dihydropyrano[3,2-h][1,4]benzodioxin-9-one
• CAS: 1137653-03-2
• 化学式: C₂₀H₁₈O₈
• 分子量: 386.358
• InChiKey: XGADTAYOFHOFIW-RDJZCZTQSA-N

物化性质

• 沸点：
  632.7±55.0 °C(Predicted)
• 密度：
  1.403±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  28
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  104
• 氢给体数：
  2
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  秦皮素 、 反式-3-(4-羟基-3-甲氧基苯基)-2-丙烯-1-醇 在 二苯基硒亚砜 作用下， 以 甲醇 、 苯 为溶剂， 反应 0.5h， 生成 cleomiscosin A 、 6-methoxy-5′′-demethoxydaphneticin 、 8'-epi-cleomiscosin A 、
  参考文献：
  名称：

  Syntheses of Natural Coumarinolignans: Oxidative Coupling of 7,8-Dihydroxycoumarins and Phenylpropenes in the Presence of Diphenyl Selenoxide

  摘要：

  DOI：

  10.3987/com-88-4747

文献信息

• METHOD AND SYSTEM FOR EFFECTING CHANGES IN PIGMENTED TISSUE
  申请人：Moazed Kambiz Thomas

  公开号：US20110280909A1

  公开（公告）日：2011-11-17

  Methods and systems are described for a rapid and sustainable change in the pigment melanin content of melanocytes of the iris stroma, thereby to change the color of the eye. Also described are nanoparticle compositions for lightening the pigmented tissues or treating a pigmented tissue related disease.

  描述了一种快速和可持续改变虹膜基质黑色素含量的黑色素细胞的方法和系统，从而改变眼睛的颜色。还描述了用于淡化有色组织或治疗有色组织相关疾病的纳米颗粒组合物。
• Method and system for effecting changes in pigmented tissue
  申请人：Moazed Kambiz Thomas

  公开号：US20120207809A1

  公开（公告）日：2012-08-16

  Methods and systems are described for a rapid and sustainable change in the pigment melanin content of melanocytes of the iris stroma, thereby to change the color of the eye. Also described are compositions for lightening or darkening the pigmented tissues or treating a pigmented tissue disease.

  本文描述了一种快速和可持续改变虹膜基质黑素细胞中黑色素含量的方法和系统，从而改变眼睛的颜色。还描述了用于使色素组织变浅或变深或治疗色素组织疾病的组合物。
• Cancer chemopreventative compounds and compositions and methods of treating cancers
  申请人：——

  公开号：US20020193425A1

  公开（公告）日：2002-12-19

  A composition and method of cancer treatment is disclosed. The composition and method utilize brusatol, bruceantin, glaucarubolone, and derivatives thereof as active cancer treating agent in mammals, including humans.

  本研究公开了一种癌症治疗组合物和方法。该组合物和方法利用布鲁沙托、布鲁沙托、格拉鲁勃龙及其衍生物作为哺乳动物（包括人类）的活性癌症治疗剂。
• Immunomodulatory pharmaceutical composition and a process for preparation thereof
  申请人：Khanuja Preet Singh Suman

  公开号：US20070258989A1

  公开（公告）日：2007-11-08

  The present invention provides a novel pharmaceutical composition consisting of a combination of three coumarinolignoids of formula 1, 2 and 3 isolated from the seeds of the plant Cleome viscose along with a pharmaceutically acceptable carrier useful as a immunomodulator. The invention also describes the ability of the compounds to modulate humorral and cell mediated immune response. It further provides a process for the preparation of a novel pharmaceutical composition of the said three coumarinolignoids in an optimized ratio to modulate humorral and cell mediated immune response.
• MAPLE TREE-DERIVED PRODUCTS AND USES THEREOF
  申请人：Barbeau Julie

  公开号：US20130310332A1

  公开（公告）日：2013-11-21

  The present document describes a neutraceutical, cosmeceuticals, functional food, pharmaceutical, food ingredient, and non-food ingredient compositions comprising sugar maple extract, essential oil compositions comprising oil extracted from an Acer tree, sweetening compositions containing sugar extracted from maple tree leaves, food ingredients comprising maple tree extract, cosmetic composition comprising maple tree extracts, infusion compositions prepared from maple tree leaves, maple roots, maple wood, maple stems of leaves and samara, and stems/twigs as well as compounds isolated from sugar maple biomass and the methods of extracting the same.