2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethyl 4-benzylpiperidine-1-carbodithioate | 1353898-22-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethyl 4-benzylpiperidine-1-carbodithioate
• 英文别名: 2-(2-Methyl-5-nitroimidazol-1-yl)ethyl 4-benzylpiperidine-1-carbodithioate
• CAS: 1353898-22-2
• 化学式: C₁₉H₂₄N₄O₂S₂
• 分子量: 404.557
• InChiKey: SPMWPYDKIGTXPN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  27
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  124
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  甲硝唑 在 咪唑 、 碘 、 三苯基膦 作用下， 以 甲苯 为溶剂， 反应 4.0h， 生成 2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethyl 4-benzylpiperidine-1-carbodithioate
  参考文献：
  名称：

  Potentiating Metronidazole Scaffold against Resistant Trichomonas: Design, Synthesis, Biology and 3D–QSAR Analysis

  摘要：

  Metronidazole (MTZ), the FDA-approved drug against Trichomonas vaginalis (TV), is being challenged seriously by drug resistance, while its inertness to sperm makes it ineffective as a vaginal contraceptive. Thirteen piperidine dithiocarbamate hybrids of 2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethane (8-20) were designed to potentiate the MTZ framework against drug resistance and sperm. New compounds were 1.2-12.1 times more effective against MTZ-susceptible and -resistant strains of TV. All of the compounds exhibited high safety toward cervical (HeLa) cells and Lactobacillus. Thirty-eight compounds were scrutinized by CoMFA and CoMSIA techniques of 3D quantitative structure activity relationship. Good predictive r(pred)(2) values for CoMFA and CoMSIA models reflected the robustness of the predictive ability. This was validated by designing five new analogues (46-50), which were potently microbicidal (3-10 and 10-20 times against MTZ-susceptible and -resistant TV, respectively) and spermicidal. This in vitro study may have significant clinical relevance, which could become evident in due course.

  DOI：

  10.1021/ml200161t

文献信息

• Potentiating Metronidazole Scaffold against Resistant Trichomonas: Design, Synthesis, Biology and 3D–QSAR Analysis
  作者：Lalit Kumar、Ashish Jain、Nand Lal、Amit Sarswat、Santosh Jangir、Lokesh Kumar、Vishal Singh、Priyanka Shah、Swatantra K. Jain、Jagdamba P. Maikhuri、Mohammad I. Siddiqi、Gopal Gupta、Vishnu L. Sharma

  DOI：10.1021/ml200161t

  日期：2012.2.9

  Metronidazole (MTZ), the FDA-approved drug against Trichomonas vaginalis (TV), is being challenged seriously by drug resistance, while its inertness to sperm makes it ineffective as a vaginal contraceptive. Thirteen piperidine dithiocarbamate hybrids of 2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethane (8-20) were designed to potentiate the MTZ framework against drug resistance and sperm. New compounds were 1.2-12.1 times more effective against MTZ-susceptible and -resistant strains of TV. All of the compounds exhibited high safety toward cervical (HeLa) cells and Lactobacillus. Thirty-eight compounds were scrutinized by CoMFA and CoMSIA techniques of 3D quantitative structure activity relationship. Good predictive r(pred)(2) values for CoMFA and CoMSIA models reflected the robustness of the predictive ability. This was validated by designing five new analogues (46-50), which were potently microbicidal (3-10 and 10-20 times against MTZ-susceptible and -resistant TV, respectively) and spermicidal. This in vitro study may have significant clinical relevance, which could become evident in due course.