1-((piperidin-1-yl)-(thiophen-2-yl)-methyl)naphthalen-2-ol | 270262-85-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 1-((piperidin-1-yl)-(thiophen-2-yl)-methyl)naphthalen-2-ol
• 英文别名: 1-[Piperidin-1-yl(thiophen-2-yl)methyl]naphthalen-2-ol
• CAS: 270262-85-6
• 化学式: C₂₀H₂₁NOS
• 分子量: 323.459
• InChiKey: BSMWPQRBSSDOCB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  23
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  51.7
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  哌啶 、 2-噻吩甲醛 、 2-萘酚 以 乙醇 为溶剂， 反应 120.33h， 以78%的产率得到1-((piperidin-1-yl)-(thiophen-2-yl)-methyl)naphthalen-2-ol
  参考文献：
  名称：

  衍生自2-萘酚，芳香醛和仲脂肪胺的曼尼希碱的抗菌活性

  摘要：

  通过2-萘酚与（杂）芳族醛和仲胺的直接Mannich反应合成了一个小的1-氨基烷基2-萘酚文库。所有结构中具有噻吩-2-基环的曼尼希碱基均对革兰氏阳性细菌具有良好的活性，而与氨基部分的性质无关。

  DOI：

  10.1016/j.bmcl.2016.03.098

文献信息

• Synthesis of 1‐aminoalkyl‐2‐naphthols derivatives using an engineered copper‐based nanomagnetic catalyst (Fe ₃ O ₄ @CQD@Si (OEt)(CH ₂ ) ₃ NH@CC@N ₃ @phenylacetylene@Cu)
  作者：Tahereh Akbarpour、Ardeshir Khazaei、Jaber Yousefi Seyf、Negin Sarmasti

  DOI：10.1002/aoc.6361

  日期：2021.10

  present study, a molecular level engineered-based method was used to synthesis a copper-based nanomagnetic catalyst (Fe3O4@CQD@Si (OEt)(CH2)3NH@CC@N3@phenylacetylene@Cu). The as-synthesized catalyst was characterized using different techniques, including infrared (IR), X-ray powder diffraction (XRD), field emission scanning electron microscopy (FESEM) and transmission electron microscopy (TEM), energy-dispersive

  在本研究中，基于分子水平的工程化方法用于合成铜基纳米磁性催化剂（Fe 3 O 4 @CQD@Si (OEt)(CH 2 ) 3 NH@CC@N 3 @苯基乙炔@Cu） . 使用不同的技术对合成的催化剂进行表征，包括红外（IR）、X 射线粉末衍射（XRD）、场发射扫描电子显微镜（FESEM）和透射电子显微镜（TEM）、能量色散 X 射线光谱（ EDX) 和 EDX 元素映射、感应耦合等离子体 (ICP)、热重分析 (TGA) 和差热分析 (DTA) 以及振动样品磁强计 (VSM)。Fe 3 O 4使用碳量子点 (CQD) 代替传统的 SiO 2保护纳米粒子表面. 在 1-氨基烷基-2-萘酚衍生物的合成中评估了所合成催化剂的活性。反应时间短、反应收率高的无溶剂条件是所制备催化剂的结果。反应如何被催化剂触发由 IR 确定。合成后的催化剂在五个循环后提供了 87.5% 的反应产率。采用傅里叶变换红外
• Aluminatesulfonic acid: Novel and recyclable nanocatalyst for efficient synthesis of aminoalkyl naphthols and amidoalkyl naphthols
  作者：Masoud Nasr-Esfahani、Morteza Montazerozohori、Mahbube Taei

  DOI：10.1016/j.crci.2016.02.003

  日期：2016.8

  Résumé In this study, an efficient, mild, and eco-friendly procedure is developed for the preparation of 1-amidoalkyl-2-naphthols and Betti bases from one-pot three-component condensation of aldehydes, 2-naphthol, and nitrogen sources (amides for amidoalkyl naphthols and amine for Betti bases) in the presence of aluminatesulfonic acid nanoparticles (ASA NPs) as recoverable catalyst under solvent-free conditions. ASA NPs were prepared by a simple reaction of net chlorosulfonic acid and sodium aluminate in high purity. ASA NPs were characterized by Fourier transform IR, X-ray powder diffraction, transmission electron microscopy, energy-dispersive X-ray, thermal gravimetric analysis, and UV diffusion/reflectance techniques. On the basis of the thermal gravimetric analysis and some activation parameters evaluated from decomposition thermal steps using Coats–Redfern model, the catalyst showed high thermal stability. High yields, short reaction time, easy workup, inexpensive, and reusability of the catalyst are advantages of this method.

  摘要 在本研究中，开发了一种高效、温和且环保的程序，用于通过醛、2-萘酚和氮源（用于酰胺烷基萘酚的酰胺和用于Betti碱的胺）的一锅三组分缩合制备1-酰胺烷基-2-萘酚和Betti碱，反应在无溶剂条件下进行，使用铝酸盐磺酸纳米颗粒（ASA NPs）作为可回收催化剂。ASA NPs通过净氯磺酸与高纯度铝酸钠的简单反应制备。 ASA NPs通过傅里叶变换红外光谱、X射线粉末衍射、透射电子显微镜、能量色散X射线、热重分析和UV扩散/反射技术进行了表征。根据热重分析和使用Coats-Redfern模型评估的分解热步骤的一些活化参数，催化剂显示出高热稳定性。该方法的优点包括高产率、短反应时间、容易的后处理、成本低廉以及催化剂的可重用性。
• Design and identification of nano‐Mg‐[4‐methoxy phenyl‐salicylaldimine–methyl‐pyranopyrzole] Cl ₂ and its catalytic application on the preparation of 1‐(α‐aminoalkyl)‐2‐naphthols
  作者：Hamid Goudarziafshar、Ahmad Reza Moosavi‐Zare、Jafar Hasani

  DOI：10.1002/aoc.5372

  日期：2020.3

  prepared and fully characterized using some various techniques including fourier transform infrared spectroscopy (FT‐IR), energy‐dispersive x‐ray spectroscopy (EDS), X‐ray diffraction (XRD), thermal gravimetric analysis (TGA), differential thermal gravimetric analysis (DTA), mass spectroscopy (MS) and scanning electron microscopy (SEM). Nano‐[Mg‐4MSMP]Cl2 was successfully used as an efficient catalyst for

  制备了纳米Mg- [4-甲氧基苯基水杨基亚胺基甲基吡喃并吡唑] Cl 2（纳米-[Mg-4MSMP] Cl 2）作为纳米席夫碱复合物，并使用包括傅里叶变换红外光谱（FT-IR）在内的多种技术对其进行了全面表征，能量色散X射线光谱（EDS），X射线衍射（XRD），热重分析（TGA），差示热重分析（DTA），质谱（MS）和扫描电子显微镜（SEM）。纳米[Mg-4MSMP] Cl 2被成功地用作制备某些1-（α-氨基烷基）-2-萘酚的有效催化剂。
• Supported copper triflate as an efficient catalytic system for the synthesis of highly functionalized 2-naphthol Mannich bases under solvent free condition
  作者：Someshwar D. Dindulkar、Vedavati G. Puranik、Yeon Tae Jeong

  DOI：10.1016/j.tetlet.2012.06.022

  日期：2012.8

  Various heterogeneous catalysts (Lewis acid) have been prepared and screened for the synthesis of Betti bases in an attempt to reduce the environmental hazards associated with the conventional homogeneous Lewis acid system. And we found especially Cu(OTf)(2)center dot SiO2 catalyzes the three-component coupling of aldehyde, 2-naphthol, and alicyclic amine to generate Betti base with high efficiency under neat conditions without additional co-catalyst or additive in air. The reaction is not sensitive to water and occurs smoothly in water as well. (c) 2012 Elsevier Ltd. All rights reserved.
• IRON(III) CONTAINING COMPLEX AND CONDENSATION REACTION CATALYSTS, METHODS FOR PREPARING THE CATALYSTS, AND COMPOSITIONS CONTAINING THE CATALYSTS
  申请人：Dow Corning Corporation

  公开号：EP2764052A2

  公开（公告）日：2014-08-13