1-(p-hydroxybenzyl)-2-naphthol | 4895-95-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 1-(p-hydroxybenzyl)-2-naphthol
• 英文别名: 1-(4-hydroxybenzyl)naphthalen-2-ol；1-[(4-Hydroxyphenyl)methyl]naphthalen-2-ol
• CAS: 4895-95-8
• 化学式: C₁₇H₁₄O₂
• 分子量: 250.297
• InChiKey: DWZJXWARJZXIMU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  40.5
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  (4-methoxymethoxyphenyl)methanol 在 4-二甲氨基吡啶 、 三乙胺 作用下， 以 乙醇 、 二氯甲烷 、 甲苯 为溶剂， 反应 3.0h， 生成 1-(p-hydroxybenzyl)-2-naphthol
  参考文献：
  名称：

  Facile synthesis of diarylmethanes via quinone methides

  摘要：

  A novel acid-mediated generation of quinone methides followed by nucleophilic addition of electron-rich aromatic compounds to furnish diarylmethanes has been developed. A wide range of electron-rich aromatic compounds including some heterocycles can be employed for this reaction to provide the corresponding diarylmethanes in good yields and regioselectivities. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2012.10.087

文献信息

• Bowman, Peter J.; Brown, Ben R.; Chapman, M. Andrew, Journal of Chemical Research, Miniprint, 1984, # 3, p. 701 - 770
  作者：Bowman, Peter J.、Brown, Ben R.、Chapman, M. Andrew、Doyle, Paul M.

  DOI：——

  日期：——
• BOWMAN, P. J.;BROWN, B. R.;CHAPMAN, M. A.;DOYLE, P. M., J. CHEM. RES. MICROFICHE, 1984, N 3, 72-73
  作者：BOWMAN, P. J.、BROWN, B. R.、CHAPMAN, M. A.、DOYLE, P. M.

  DOI：——

  日期：——
• Facile synthesis of diarylmethanes via quinone methides
  作者：Kassrin Tangdenpaisal、Wong Phakhodee、Somsak Ruchirawat、Poonsakdi Ploypradith

  DOI：10.1016/j.tet.2012.10.087

  日期：2013.1

  A novel acid-mediated generation of quinone methides followed by nucleophilic addition of electron-rich aromatic compounds to furnish diarylmethanes has been developed. A wide range of electron-rich aromatic compounds including some heterocycles can be employed for this reaction to provide the corresponding diarylmethanes in good yields and regioselectivities. (C) 2012 Elsevier Ltd. All rights reserved.