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[3-(3-carbamoylphenyl)phenyl] N-[4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butyl] carbamate | 1607444-05-2

中文名称
——
中文别名
——
英文名称
[3-(3-carbamoylphenyl)phenyl] N-[4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butyl] carbamate
英文别名
[3-(3-carbamoylphenyl)phenyl] N-[3-[4-(2,3-dichlorophenyl)piperazin-1-yl]propyl]carbamate
[3-(3-carbamoylphenyl)phenyl] N-[4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butyl] carbamate化学式
CAS
1607444-05-2
化学式
C27H28Cl2N4O3
mdl
——
分子量
527.45
InChiKey
CDXLFYUUESQKHV-UHFFFAOYSA-N
BEILSTEIN
——
EINECS
——
  • 物化性质
  • 计算性质
  • ADMET
  • 安全信息
  • SDS
  • 制备方法与用途
  • 上下游信息
  • 反应信息
  • 文献信息
  • 表征谱图
  • 同类化合物
  • 相关功能分类
  • 相关结构分类

计算性质

  • 辛醇/水分配系数(LogP):
    5.2
  • 重原子数:
    36
  • 可旋转键数:
    9
  • 环数:
    4.0
  • sp3杂化的碳原子比例:
    0.26
  • 拓扑面积:
    87.9
  • 氢给体数:
    2
  • 氢受体数:
    5

反应信息

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文献信息

  • [EN] PHENYL CARBAMATES AND THEIR USE AS INHIBITORS OF THE FATTY ACID AMIDE HYDROLASE (FAAH) ENZYME AND MODULATORS OF THE D3 DOPAMINE RECEPTOR (D3DR)<br/>[FR] PHENYL CARBAMATES ET LEUR UTILISATION COMME INHIBITEURS DE L'ENZYME HYDROLASE D'AMIDES D'ACIDES GRAS (FAAH) ET MODULATEURS DU RÉCEPTEUR D3 DE LA DOPAMINE (D3DR)
    申请人:FOND ISTITUTO ITALIANO DI TECNOLOGIA
    公开号:WO2015007615A1
    公开(公告)日:2015-01-22
    The invention provides compounds of Formula (I) or pharmaceutically acceptable salts thereof wherein Ar', R1, R2, R3, R4, X, Y are as defined in the description of invention, as multi-target directed ligands (MTDLs) that are at the same time inhibitors of the fatty acid amide hydrolase (FAAH) enzyme and modulators of the D3 dopamine receptor (D3DR), their methods of preparation, formulations and therapeutic applications thereof.
    该发明提供了式(I)的化合物或其药用可接受的盐,其中Ar',R1,R2,R3,R4,X,Y如发明描述中所定义,作为多靶点定向配体(MTDLs),同时是脂肪酸酰胺水解酶(FAAH)酶的抑制剂和D3多巴胺受体(D3DR)的调节剂,以及它们的制备方法、配方和治疗应用。
  • PHENYL CARBAMATES AND THEIR USE AS INHIBITORS OF THE FATTY ACID AMIDE HYDROLASE (FAAH) ENZYME AND MODULATORS OF THE D3 DOPAMINE RECEPTOR (D3DR)
    申请人:FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA
    公开号:US20160194296A1
    公开(公告)日:2016-07-07
    The invention provides compounds of Formula (I) or pharmaceutically acceptable salts thereof wherein Ar′, R 1 , R 2 , R 3 , R 4 , X, Y are as defined in the description of invention, as multi-target directed ligands (MTDLs) that are at the same time inhibitors of the fatty acid amide hydrolase (FAAH) enzyme and modulators of the D3 dopamine receptor (D3DR), their methods of preparation, formulations and therapeutic applications thereof.
    本发明提供了化合物I或其药学上可接受的盐,其中Ar′、R1、R2、R3、R4、X、Y的定义如本发明描述中所述,作为多靶点定向配体(MTDLs),同时作为脂肪酸酰胺水解酶(FAAH)酶的抑制剂和D3多巴胺受体(D3DR)的调节剂,以及它们的制备方法、配方和治疗应用。
  • US9828352B2
    申请人:——
    公开号:US9828352B2
    公开(公告)日:2017-11-28
  • Applying a multitarget rational drug design strategy: the first set of modulators with potent and balanced activity toward dopamine D3 receptor and fatty acid amide hydrolase
    作者:Alessio De Simone、Gian Filippo Ruda、Clara Albani、Glauco Tarozzo、Tiziano Bandiera、Daniele Piomelli、Andrea Cavalli、Giovanni Bottegoni
    DOI:10.1039/c4cc00967c
    日期:——

    The first set of rationally conceived dual dopamine D3 receptor (DRD3) and fatty acid amide hydrolase (FAAH) modulators is presented.

    第一套合理构思的双重多巴胺D3受体(DRD3)和脂肪酸酰胺水解酶(FAAH)调节剂被提出。
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