4-(4-chlorophenyl)-5-methyl-N-(naphthalen-1-yl)thiazol-2-amine | 413573-81-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 4-(4-chlorophenyl)-5-methyl-N-(naphthalen-1-yl)thiazol-2-amine
• 英文别名: 4-(4-chlorophenyl)-5-methyl-N-naphthalen-1-yl-1,3-thiazol-2-amine
• CAS: 413573-81-6
• 化学式: C₂₀H₁₅ClN₂S
• 分子量: 350.871
• InChiKey: HJOAHWCOVUSHEN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.8
• 重原子数：
  24
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  53.2
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2 -溴- 4 -氯苯丙酮 、 potassium thioacyanate 、 1-萘胺 以 甲醇 为溶剂， 反应 0.5h， 以82%的产率得到4-(4-chlorophenyl)-5-methyl-N-(naphthalen-1-yl)thiazol-2-amine
  参考文献：
  名称：

  Substituted 2-aminothiazoles are exceptional inhibitors of neuronal degeneration in tau-driven models of Alzheimer’s disease

  摘要：

  A novel series of 2-aminothiazoles with strong protection in an Alzheimer's disease (AD) model comprising tau-induced neuronal toxicity is disclosed. These derivatives can be synthesized in one-pot and a small SAR of the substitution within these series afforded several compounds that counteracted tau-induced cell toxicity at nanomolar concentrations. These congeners therefore have strong potential as possible treatment for Alzheimer's disease and other related tauopathies. (C) 2011 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.ejps.2011.05.014

文献信息

• Substituted 2-aminothiazoles are exceptional inhibitors of neuronal degeneration in tau-driven models of Alzheimer’s disease
  作者：Irene Lagoja、Christophe Pannecouque、Gerard Griffioen、Stefaan Wera、Veronica Maria Rojasdelaparra、Arthur Van Aerschot

  DOI：10.1016/j.ejps.2011.05.014

  日期：2011.8

  A novel series of 2-aminothiazoles with strong protection in an Alzheimer's disease (AD) model comprising tau-induced neuronal toxicity is disclosed. These derivatives can be synthesized in one-pot and a small SAR of the substitution within these series afforded several compounds that counteracted tau-induced cell toxicity at nanomolar concentrations. These congeners therefore have strong potential as possible treatment for Alzheimer's disease and other related tauopathies. (C) 2011 Elsevier B.V. All rights reserved.