2-[6-(4′-hydroxy)phenoxy-3H-xanthen-3-on-9-yl]benzoic acid | 686773-84-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 2-[6-(4′-hydroxy)phenoxy-3H-xanthen-3-on-9-yl]benzoic acid
• 英文别名: 2-[6-(4'-hydroxy)phenoxy-3H-xanthen-3-on-9-yl]benzoic acid；2-[6-(4-hydroxyphenoxy)-3H-xanthen-3-on-9-yl]benzoic acid；3'-(p-hydroxyphenyl)fluorescein；hydroxyphenyl fluorescein；HPF；HPR；2-(6-(4-Hydroxyphenoxy)-3-oxo-3H-xanthen-9-yl)benzoic acid；2-[3-(4-hydroxyphenoxy)-6-oxoxanthen-9-yl]benzoic acid
• CAS: 686773-84-2
• 化学式: C₂₆H₁₆O₆
• 分子量: 424.409
• InChiKey: PJVNNUVJKCWFRU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  32
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  93.1
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  2-[6-(4′-hydroxy)phenoxy-3H-xanthen-3-on-9-yl]benzoic acid 在 titanium(IV) oxide 作用下， 生成 荧光素
  参考文献：
  名称：

  锐钛矿型与金红石型纳米颗粒之间光催化活性差异的分子水平理解

  摘要：

  光照下的光催化剂上氧化剂的产生及其在后续反应中的参与，是广泛研究用于环境修复和选择性氧化的光催化过程的主要基础。在此，的生成和随后的扩散。使用单分子检测方法可以直接观察从被照射的TiO 2表面到溶液体积的OH ，这种分子现象可以解释光催化中锐钛矿和金红石的不同宏观行为。流动的。OH是由锐钛矿生成的，而不是金红石生成的。因此，由于存在移动性，在金红石上的光催化氧化仅限于吸附的底物，而在锐钛矿上的光催化氧化则更容易和通用。哦。锐钛矿产生流动蛋白的能力。提议将OH作为以前无法​​识别的关键因素，解释了通常的观察结果：锐钛矿在许多光氧化反应中比金红石具有更高的活性。

  DOI：

  10.1002/anie.201406625

文献信息

• Mechanism of action of sensors for reactive oxygen species based on fluorescein–phenol coupling: the case of 2-[6-(4′-hydroxy)phenoxy-3H-xanthen-3-on-9-yl]benzoic acid
  作者：Belinda Heyne、Vincent Maurel、J. C. Scaiano

  DOI：10.1039/b515751j

  日期：——

  tethered fluorescein-phenol structure to react with peroxyl radicals and with an oxidizing agent such as potassium ferricyanide. This latter reaction yields the corresponding peroxyl radical as observed by EPR analysis. We propose that the reaction of the sensor with peroxyl and alkoxyl radicals is also initiated by the formation of the phenoxyl radicals, which is followed by radical-radical reactions and

  我们演示了包含系留的荧光素-苯酚结构的传感器与过氧自由基和氧化剂（如铁氰化钾）反应的能力。如EPR分析所观察到的，后一反应产生相应的过氧自由基。我们提出传感器与过氧和烷氧基的反应也通过苯氧基的形成而引发，然后自由基反应和负责荧光素释放的产物水解。所提出的机理是基于通过激光闪光光解，HPLC和EPR研究过氧自由基和烷氧基自由基与4-苯氧基苯酚（一种用于模拟传感器性能的分子）的反应而获得的结果。
• REAGENTS FOR THE MEASUREMENT OF PEROXYNITRITES
  申请人：DAIICHI PURE CHEMICALS CO., LTD.

  公开号：EP1553409A1

  公开（公告）日：2005-07-13

  A reagent for measuring peroxynitrite comprising a compound represented by the following general formula (I): wherein R1 represents an amino group, or hydroxy group; R2 represents a 2-carboxyphenyl group; and X1 and X2 independently represent hydrogen atom, or a halogen atom (e.g., 2-[6-(4'-hydroxy)phenoxy -3H-xanthen-3-on-9-yl]benzoic acid, or 2-[6-(4'-amino)phenoxy-3H-xanthen-3-on-9-yl]benzoic acid) or a salt thereof, which does not react with superoxide or nitrogen monoxide, a precursor of peroxynitrite, and specifically reacts with peroxynitrite.

  一种测量过亚硝酸盐的试剂，包括由以下通式(I)代表的化合物： 其中 R1 代表氨基或羟基；R2 代表 2-羧基苯基；X1 和 X2 独立地代表氢原子或卤素原子（例如、2-[6-(4'-羟基)苯氧基-3H-氧杂蒽-3-on-9-基]苯甲酸，或 2-[6-(4'-氨基)苯氧基-3H-氧杂蒽-3-on-9-基]苯甲酸）或其盐，它不与过亚硝酸盐的前体超氧化物或一氧化氮反应，而专门与过亚硝酸盐反应。
• SCAVENGER OF HARMFUL ACTIVE OXYGEN AND/OR FREE RADICAL IN LIVING BODY
  申请人：Ohta, Shigeo

  公开号：EP1946762A1

  公开（公告）日：2008-07-23

  An object of the present invention is to provide a scavenger of in vivo harmful reactive oxygen species and/or free radicals, which is capable of effectively reducing the concentrations of in vivo reactive oxygen species and/or free radicals and exhibiting given effects such as the suppression of aging process, the prevention of geriatric or lifestyle-related disease, health promotion, and the inhibition of oxidative stress by virtue of this reduction in the concentrations of reactive oxygen species and/or free radicals. The scavenger of in vivo harmful reactive oxygen species and/or free radicals of the present invention comprises a liquid or gas comprising at least a hydrogen molecule. This medium may further comprise an oxygen molecule. Furthermore, this medium may comprise water or an aqueous solution or may be a gas. The scavenger of reactive oxygen species and/or free radicals can be used in the treatment or prevention of a disorder attributed to reactive oxygen species and/or free radicals.

  本发明的目的是提供一种体内有害活性氧和/或自由基的清除剂，它能够有效降低体内活性氧和/或自由基的浓度，并通过降低活性氧和/或自由基的浓度而显示出抑制衰老过程、预防老年病或与生活方式有关的疾病、促进健康和抑制氧化应激等效果。本发明的体内有害活性氧和/或自由基清除剂包括至少含有一个氢分子的液体或气体。该介质可进一步包含氧分子。此外，这种介质可以是水或水溶液，也可以是气体。活性氧和/或自由基清除剂可用于治疗或预防活性氧和/或自由基引起的疾病。
• TUMOR-SELECTIVE FLUORESCENT DYE
  申请人：The University of Tokyo

  公开号：EP1990063A1

  公开（公告）日：2008-11-12

  [Object] To provide a staining agent that is capable of achieving selective fluorescent staining of a tumor cell or a tumor tissue. [Means to Achieve the Object] A tumor cell or tumor tissue-selective fluorescent staining agent comprising a compound represented by the following general formula (I): wherein R1 and R2 independently represent a C1-C4 alkyl group which may be substituted, a C2-C4 alkenyl group which may be substituted, a C2-C4 alkynyl group which may be substituted, an aryl group which may be substituted, or a heteroaryl group which may be substituted.

  [目的] 提供一种能够对肿瘤细胞或肿瘤组织进行选择性荧光染色的染色剂。 [实现方法】一种肿瘤细胞或肿瘤组织选择性荧光染色剂，由以下通式（I）代表的化合物组成：） 其中 R1 和 R2 独立地代表可被取代的 C1-C4 烷基、可被取代的 C2-C4 烯基、可被取代的 C2-C4 炔基、可被取代的芳基或可被取代的杂芳基。
• NOVEL HYDROXY RADICAL GENERATION METHOD, AND ANTI-VIRAL MATERIAL UTILIZING HYDROXY RADICAL GENERATED BY THE METHOD
  申请人：Mochigase Co., Ltd.

  公开号：EP2241321A1

  公开（公告）日：2010-10-20

  Disclosed is a novel hydroxy radical generation method which relies on a novel scientific fact relating to the generation of a hydroxy radical and the inactivation of a virus. Also disclosed is an anti-viral material produced by utilizing the method. The anti-viral material comprises a metal oxide powder and a hydroxide which enable the generation of a hydroxy radical that can inactivate a virus. An virus can be inactivated by the action of the hydroxy radical generated from the anti-viral material.

  本发明公开了一种新型羟基自由基生成方法，该方法依赖于与羟基自由基生成和病毒灭活有关的新科学事实。还公开了一种利用该方法生产的抗病毒材料。该抗病毒材料由金属氧化物粉末和氢氧化物组成，可产生羟基自由基，从而灭活病毒。病毒可在抗病毒材料产生的羟基自由基的作用下失活。