3'-hydroxy-spiro[phthalan-1,9'-xanthen]-3-one | 2321-06-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 3'-hydroxy-spiro[phthalan-1,9'-xanthen]-3-one
• 英文别名: 3'-Hydroxy-spiro[phthalan-1,9'-xanthen]-3-on；3'-Hydroxyfluoran；Fluorescein；6-Hydroxyfluoran；3'-hydroxyspiro[2-benzofuran-3,9'-xanthene]-1-one
• CAS: 2321-06-4
• 化学式: C₂₀H₁₂O₄
• 分子量: 316.313
• InChiKey: XQSMVCKZZJVTHZ-UHFFFAOYSA-N

物化性质

• 沸点：
  558.2±50.0 °C(Predicted)
• 密度：
  1.50±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  24
• 可旋转键数：
  0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  55.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  荧光素 在 sodium hydroxide 、 硫酸 作用下， 生成 3'-hydroxy-spiro[phthalan-1,9'-xanthen]-3-one
  参考文献：
  名称：

  Ghatak; Dutt, Journal of the Indian Chemical Society, 1929, vol. 6, p. 468

  摘要：

  DOI：

文献信息

• ALKYLATED PHOTOREMOVABLE PROTECTING GROUPS AND USES THEREOF
  申请人：Iowa State University Research Foundation, Inc.

  公开号：US20190231873A1

  公开（公告）日：2019-08-01

  The invention relates to a method for photoreleasing a moiety G from a compound of the formula A-G. The methods of the present invention comprise irradiating a composition comprising the compound of the formula A-G at a wavelength of >500 nm, so as to photorelease the moiety G from the moiety A; wherein the moiety A comprises a chromophore and the moiety G comprises an organic compound.

  该发明涉及一种从公式A-G的化合物中光释放基团G的方法。本发明的方法包括照射包含公式A-G化合物的组合物，波长>500纳米，以使基团G从基团A中光释放；其中，基团A包括一个色素基团，基团G包括一个有机化合物。
• PHOTOREMOVABLE PROTECTING GROUPS AND USES THEREOF
  申请人：Iowa State University Research Foundation, Inc.

  公开号：US20160228845A1

  公开（公告）日：2016-08-11

  The invention relates to a method for photoreleasing a moiety G from a compound of the formula A-G. The methods of the present invention comprise irradiating a composition comprising the compound of the formula A-G at a wavelength of >500 nm, so as to photorelease the moiety G from the moiety A; wherein the moiety A comprises a chromophore and the moiety G comprises an organic compound.

  本发明涉及一种从化合物A-G中光释放基团G的方法。本发明的方法包括照射公式A-G化合物的组合物，波长大于500nm，以光释放基团G从基团A中释放出来；其中基团A包括色团，基团G包括有机化合物。
• PEPTIDE COMPOUNDS FOR REDUCING SIDE EFFECTS OF CB1 RECEPTOR AGONISTS
  申请人：Universitat de Barcelona

  公开号：EP3800195A1

  公开（公告）日：2021-04-07

  The present invention relates to compounds of formula (I) or a pharmaceutically acceptable salts thereof, to processes for their obtention and to their therapeutic indications.

  本发明涉及式 (I) 的化合物 或其药学上可接受的盐类、获得它们的工艺以及它们的治疗适应症。
• Photoresist underlayer film-forming composition and pattern forming processes
  申请人：Shin-Etsu Chemical Co., Ltd.

  公开号：EP2813892B1

  公开（公告）日：2020-06-17
• PROBES FOR RAPID AND SPECIFIC DETECTION OF MYCOBACTERIA
  申请人：The Board of Trustees of the Leland Stanford Junior University

  公开号：US20170044593A1

  公开（公告）日：2017-02-16

  The compositions of the present disclosure provide novel fluorogenic probes for use in the specific imaging and detection of mycobacteria species, and in particular β-lactam-antibiotic resistant. Specificity for mycobacteria is conferred on these probes by incorporating a moiety that specifically targets the unique trapping mechanism of the DprE1 found in in mycobacteria. Accordingly, only Mycobacteria species that express both a β-lactamase and DprE1 enable both the activation of the caged fluorescent probe, and the affixing of the released fluorescent probes to the bacteria cells through the functioning reduction-covalent binding mechanism. Advantageously, such a probe is able, at its most sensitive, to allow single mycobacterium detection.