2-(Piperidin-4-ylmethyl)prop-2-enoic acid | 934477-09-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 2-(Piperidin-4-ylmethyl)prop-2-enoic acid
• 英文别名: 2-(piperidin-4-ylmethyl)prop-2-enoic acid
• CAS: 934477-09-5
• 化学式: C₉H₁₅NO₂
• 分子量: 169.224
• InChiKey: OGBSHWNCBSMVLB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.3
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  49.3
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-(Piperidin-4-ylmethyl)prop-2-enoic acid 在 ammonium hydroxide 作用下， 以 异丙醇 为溶剂， 生成 2-(Mercaptomethyl)-3-(piperidin-4-yl)propanoic acid
  参考文献：
  名称：

  3-Mercaptopropionic acids as efficacious inhibitors of activated thrombin activatable fibrinolysis inhibitor (TAFIa)

  摘要：

  A novel series of cyclic potent, selective, small molecule, thiol-based inhibitors of activated thrombin activatable fibrinolysis inhibitor (TAFIa) and the crystal structures of TAFIa inhibitors bound to porcine pancreatic carboxypeptidase B are described. Three series of cyclic arginine and lysine mimetic inhibitors vary significantly in their selectivity against other human basic carboxypeptidases, carboxypeptidase N and carboxypeptidase B. (-)2a displays TAFIa IC50 = 3 nM and 600-fold selectivity against CPN. Inhibition of TAFIa with (rac)2a resulted in dose dependent acceleration of human plasma clot lysis in vitro and was efficacious as an adjunct to tPA in an in vivo rabbit jugular vein thrombolysis model.

  DOI：

  10.1016/j.bmcl.2006.11.078
• 作为产物：
  描述：

  2-(1-tert-butoxycarbonyl-piperidin-4-ylmethyl)-malonic acid monomethyl ester 在 盐酸 、 sodium hydroxide 作用下， 以 四氢呋喃 、 1,4-二氧六环 、 水 为溶剂， 生成 2-(Piperidin-4-ylmethyl)prop-2-enoic acid
  参考文献：
  名称：

  3-Mercaptopropionic acids as efficacious inhibitors of activated thrombin activatable fibrinolysis inhibitor (TAFIa)

  摘要：

  A novel series of cyclic potent, selective, small molecule, thiol-based inhibitors of activated thrombin activatable fibrinolysis inhibitor (TAFIa) and the crystal structures of TAFIa inhibitors bound to porcine pancreatic carboxypeptidase B are described. Three series of cyclic arginine and lysine mimetic inhibitors vary significantly in their selectivity against other human basic carboxypeptidases, carboxypeptidase N and carboxypeptidase B. (-)2a displays TAFIa IC50 = 3 nM and 600-fold selectivity against CPN. Inhibition of TAFIa with (rac)2a resulted in dose dependent acceleration of human plasma clot lysis in vitro and was efficacious as an adjunct to tPA in an in vivo rabbit jugular vein thrombolysis model.

  DOI：

  10.1016/j.bmcl.2006.11.078

文献信息

• COATING COMPOSITION AND SHEET USING SAME
  申请人：Takano Yoko

  公开号：US20120288718A1

  公开（公告）日：2012-11-15

  Provided are a coating composition which provides a sheet with a visible light transmission property and a UV ray-blocking performance in addition to an excellent self-cleaning performance and a persistence thereof, a weatherability and a persistence thereof and a transparency and a sheet having a surface protective layer formed by the above composition. They are a coating composition comprising an ionizing radiation-curable resin and a hydrophilizing agent such as a silicate compound and alkyl silicate and a sheet having a surface protective layer formed by cross-linking and curing the above coating composition.
• US9221983B2
  申请人：——

  公开号：US9221983B2

  公开（公告）日：2015-12-29
• 3-Mercaptopropionic acids as efficacious inhibitors of activated thrombin activatable fibrinolysis inhibitor (TAFIa)
  作者：Imadul Islam、Judi Bryant、Karen May、Raju Mohan、Shendong Yuan、Lorraine Kent、John Morser、Lei Zhao、Ron Vergona、Kathy White、Marc Adler、Marc Whitlow、Brad O. Buckman

  DOI：10.1016/j.bmcl.2006.11.078

  日期：2007.3

  A novel series of cyclic potent, selective, small molecule, thiol-based inhibitors of activated thrombin activatable fibrinolysis inhibitor (TAFIa) and the crystal structures of TAFIa inhibitors bound to porcine pancreatic carboxypeptidase B are described. Three series of cyclic arginine and lysine mimetic inhibitors vary significantly in their selectivity against other human basic carboxypeptidases, carboxypeptidase N and carboxypeptidase B. (-)2a displays TAFIa IC50 = 3 nM and 600-fold selectivity against CPN. Inhibition of TAFIa with (rac)2a resulted in dose dependent acceleration of human plasma clot lysis in vitro and was efficacious as an adjunct to tPA in an in vivo rabbit jugular vein thrombolysis model.