1,2,3-tribromo-6-fluoro-4-(4-fluorophenyl)naphthalene | 1414890-97-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 1,2,3-tribromo-6-fluoro-4-(4-fluorophenyl)naphthalene
• 英文别名: 1,2,3-Tribromo-6-fluoro-4-(4-fluorophenyl)naphthalene
• CAS: 1414890-97-3
• 化学式: C₁₆H₇Br₃F₂
• 分子量: 476.94
• InChiKey: STURBUFVOOCOPO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.1
• 重原子数：
  21
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  1-氟-4-[4-(4-氟苯基)丁-1,3-二炔基]苯 在 溴 作用下， 以 二氯甲烷 为溶剂， 反应 6.0h， 以58%的产率得到1,2,3-tribromo-6-fluoro-4-(4-fluorophenyl)naphthalene
  参考文献：
  名称：

  Bromine-mediated cyclization of 1,4-diaryl buta-1,3-diyne to 1,2,3-tribromo-4-aryl naphthalene

  摘要：

  Bromine-mediated intramolecular cyclization of 1,4-diaryl buta-1,3-diynes has been developed for the construction of naphthalene motifs. A number of 1,2,3-tribromo-4-aryl naphthalenes are synthesized under mild reaction condition by the 6-endo-dig electrophilic cyclization of the corresponding 1,4-diaryl buta-1,3-diynes by Br-2 in moderate to excellent yields. This methodology has been successfully extended to the synthesis of 1,2,3,4-tetraphenyl naphthalene derivatives. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2012.09.079

文献信息

• Bromine-mediated cyclization of 1,4-diaryl buta-1,3-diyne to 1,2,3-tribromo-4-aryl naphthalene
  作者：Raju Singha、Sukla Nandi、Jayanta K. Ray

  DOI：10.1016/j.tetlet.2012.09.079

  日期：2012.11

  Bromine-mediated intramolecular cyclization of 1,4-diaryl buta-1,3-diynes has been developed for the construction of naphthalene motifs. A number of 1,2,3-tribromo-4-aryl naphthalenes are synthesized under mild reaction condition by the 6-endo-dig electrophilic cyclization of the corresponding 1,4-diaryl buta-1,3-diynes by Br-2 in moderate to excellent yields. This methodology has been successfully extended to the synthesis of 1,2,3,4-tetraphenyl naphthalene derivatives. (C) 2012 Elsevier Ltd. All rights reserved.