4-hydroxybenzoic acid [3-methyl-4-oxo-4H-naphthalen-(1E)-ylidene]hydrazide | 1158910-80-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 4-hydroxybenzoic acid [3-methyl-4-oxo-4H-naphthalen-(1E)-ylidene]hydrazide
• 英文别名: 4-hydroxy-N-[(E)-(3-methyl-4-oxonaphthalen-1-ylidene)amino]benzamide
• CAS: 1158910-80-5
• 化学式: C₁₈H₁₄N₂O₃
• 分子量: 306.321
• InChiKey: YBWSLHSGTYTRJC-KNTRCKAVSA-N

物化性质

• 密度：
  1.29±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.67
• 重原子数：
  23.0
• 可旋转键数：
  2.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  78.76
• 氢给体数：
  2.0
• 氢受体数：
  4.0

反应信息

• 作为产物：
  描述：

  甲萘醌 以75%的产率得到
  参考文献：
  名称：

  ROUSHDI I. M.; IBRAHIM EL S. A.; HABIB N.S., PHARMAZIE, 1976, 31, NO 12, 856-859

  摘要：

  DOI：

文献信息

• [EN] N-ACYLHYDRAZONE DERIVATIVES USEFUL AS MODULATORS OF NICOTINIC ACETYLCHOLINE RECEPTORS<br/>[FR] DÉRIVÉS DE N-ACYLHYDRAZONE UTILES EN TANT QUE MODULATEURS DES RÉCEPTEURS NICOTINIQUES DE L'ACÉTYLCHOLINE
  申请人：NEUROSEARCH AS

  公开号：WO2009065850A1

  公开（公告）日：2009-05-28

  This invention relates to N-acylhydrazone derivatives, which are found to be useful as modulators of the nicotinic acetylcholine receptors. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.

  本发明涉及N-酰基腙衍生物，这些衍生物被发现有用作为尼古丁乙酰胆碱受体调节剂。由于它们的药理特性，该发明的化合物可能对治疗与中枢神经系统（CNS）的胆碱能系统、外周神经系统（PNS）、平滑肌收缩相关的疾病或疾病、内分泌疾病或疾病、神经退行性疾病或疾病、炎症、疼痛以及由化学物质滥用终止引起的戒断症状等多种疾病或疾病可能有用。
• N-ACYLHYDRAZONE DERIVATIVES USEFUL AS MODULATORS OF NICOTINIC ACETYLCHOLINE RECEPTORS
  申请人：Nardi Antonio

  公开号：US20100292334A1

  公开（公告）日：2010-11-18

  This invention relates to N-acylhydrazone derivatives, which are found to be useful as modulators of the nicotinic acetylcholine receptors. Due to their to pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.

  本发明涉及N-酰基腙衍生物，发现其可作为尼古丁乙酰胆碱受体的调节剂。由于它们的药理特性，本发明的化合物可能有助于治疗多种疾病或障碍，如与中枢神经系统（CNS）和外周神经系统（PNS）的胆碱能系统相关的疾病或障碍、与平滑肌收缩相关的疾病或障碍、内分泌疾病或障碍、与神经退行性相关的疾病或障碍、与炎症、疼痛以及由于化学物质滥用终止而引起的戒断症状相关的疾病或障碍。
• ROUSHDI I. M.; IBRAHIM EL S. A.; HABIB N.S., PHARMAZIE, 1976, 31, NO 12, 856-859
  作者：ROUSHDI I. M.、 IBRAHIM EL S. A.、 HABIB N.S.

  DOI：——

  日期：——