4-Diethylamino-7-nitro-benz-2,1,3-oxadiazol | 74392-01-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并恶二唑类
• 英文名称: 4-Diethylamino-7-nitro-benz-2,1,3-oxadiazol
• 英文别名: 4-diethylamino-7-nitrobenzofurazan；7-diethylamino-4-nitrobenzoxadiazole；N,N-diethyl-7-nitro-2,1,3-benzoxadiazol-4-amine；N,N-diethyl-4-nitro-2,1,3-benzoxadiazol-7-amine
• CAS: 74392-01-1
• 化学式: C₁₀H₁₂N₄O₃
• mdl: MFCD00576808
• 分子量: 236.23
• InChiKey: DNINAOMAGDOEKK-UHFFFAOYSA-N

物化性质

• 熔点：
  138.0-139.5 °C(Solv: ethanol (64-17-5))
• 沸点：
  393.3±52.0 °C(Predicted)
• 密度：
  1.344±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  88
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  二乙胺 、 4-氯-7-硝基苯并-2-氧杂-1,3-二唑 以 乙醇 为溶剂， 反应 0.5h， 以97%的产率得到4-Diethylamino-7-nitro-benz-2,1,3-oxadiazol
  参考文献：
  名称：

  Fluorogenic compounds converted to fluorophores by photochemical or chemical means and their use in biological systems

  摘要：

  从可光活化的叠氮-π-受体荧光发色团或从叠氮-π-受体荧光发色团与烯烃或炔烃的热反应中衍生的荧光色团被披露。还披露了从炔烃-π-受体荧光发色团与叠氮的热反应中衍生的荧光色团。这些荧光色团可以很容易地被光激活，并可用于标记生物分子，并在活细胞中以单分子水平进行成像。

  公开号：

  US20100029952A1

文献信息

• FLUOROGENIC COMPOUNDS CONVERTED TO FLUOROPHORES BY PHOTOCHEMICAL OR CHEMICAL MEANS AND THEIR USE IN BIOLOGICAL SYSTEMS
  申请人：TWIEG ROBERT J.

  公开号：US20120190098A1

  公开（公告）日：2012-07-26

  Fluorophores derived from photoactivatable azide-pi-acceptor fluorogens or from a thermal reaction of an azide-pi-acceptor fluorogen with an alkene or alkyne are disclosed. Fluorophores derived from a thermal reaction of an alkyne-pi-acceptor fluorogen with an azide are also disclosed. The fluorophores can readily be activated by light and can be used to label a biomolecule and imaged on a single-molecule level in living cells.

  本发明揭示了从光活化偶氮-π-受体荧光原子或从偶氮-π-受体荧光原子与烯烃或炔烃进行热反应中得到的荧光原子。还揭示了从炔基-π-受体荧光原子与偶氮进行热反应中得到的荧光原子。这些荧光原子可以轻松地被光激活，并可用于标记生物分子，并在单分子水平上在活细胞中成像。
• Method and device for the manipulation of microcarriers for an identification purpose
  申请人：Biocartis SA

  公开号：EP2275819A2

  公开（公告）日：2011-01-19

  The present invention relates to a method for the manipulation for an identification purpose of a microcarrier comprising the steps of: (a) an identification purpose step of the microcarrier; and (b) a positioning and orientation step prior to or during the identification purpose step, wherein the identification purpose step is a detection step for the detection of an identifiable or encoded microcarrier and a labeling step resulting in an identifiable or encoded microcarrier. The invention further relates to an apparatus for the manipulation for identification purposes of a microcarrier comprising means for identification purposes such as a microscope or labeling means such as a high spatial resolution light source, and means for the positioning and orientation of the microcarriers and to a microcarrier suitable for use in a method according to the invention.

  本发明涉及一种为识别目的操作微载体的方法，包括以下步骤(a) 微载体的识别目的步骤；以及 (b) 识别目的步骤之前或期间的定位和定向步骤，其中识别目的步骤是检测可识别或编码微载体的检测步骤，以及产生可识别或编码微载体的标记步骤。本发明还涉及一种为识别目的操作微载体的设备，包括用于识别目的的装置（如显微镜）或标记装置（如高空间分辨率光源），以及用于微载体定位和定向的装置，还涉及一种适合用于根据本发明的方法的微载体。
• Verfahren zum Herstellen einer Hochspannungsisolierung
  申请人：Siemens Aktiengesellschaft

  公开号：EP3026676A1

  公开（公告）日：2016-06-01

  Die Erfindung betrifft ein Verfahren zum Herstellen einer Hochspannungsisolierung mit den Schritten: Beschichten von nanoskaligen und/oder mikroskaligen anorganischen Partikeln mit Spannungsstabilisatoren, organischen UV-Absorbern und/oder para-Nitroanilinen; Mischen der beschichteten Partikel mit einem Reaktionsharz, um ein Gemisch zu erhalten; und Aushärten des Gemischs. Die Erfindung betrifft ferner die Hochspannungsisolierung und die Verwendung der Hochspannungsisolierung.

  本发明涉及一种生产高压绝缘材料的工艺，包括以下步骤在纳米级和/或微米级无机颗粒上涂覆电压稳定剂、有机紫外线吸收剂和/或对硝基苯胺；将涂覆颗粒与活性树脂混合，得到混合物；以及固化混合物。本发明还涉及高压绝缘和高压绝缘的使用。
• Heberer, H.; Kersting, H.; Matschiner, H., Journal fur praktische Chemie (Leipzig 1954), 1985, vol. 327, # 3, p. 487 - 504
  作者：Heberer, H.、Kersting, H.、Matschiner, H.

  DOI：——

  日期：——
• Photophysical and Dynamic NMR Studies on 4-Amino-7-nitrobenz-2-oxa-1, 3-diazole Derivatives:  Elucidation of the Nonradiative Deactivation Pathway
  作者：Satyen Saha、Anunay Samanta

  DOI：10.1021/jp982154v

  日期：1998.10.1

  A series of 4-aminonitrobenzoxadiazole (NBD) derivatives in which the amino nitrogen is part of a four- to seven-membered heterocyclic ring and a second series of 4-dialkylamino NBD derivatives with different alkyl chain lengths have been prepared and fully characterized and their photophysical properties investigated in an attempt to find out the nonradiative deactivation pathway of the fluorescent state in these systems. It is observed that the fluorescence properties of the NBD derivatives are highly sensitive to the structure of the amino moiety and the polarity of the surrounding media. It is shown that the nonradiative rate constants for the derivatives with large alkyl groups and large ring systems are considerably higher than those for systems with smaller alkyl groups and smaller ring systems. Dynamic NMR experiments have been carried out to probe the internal motion in the systems. The internal rotation around the bond connecting the amino nitrogen and the NBD ring is found to be rather slow in the ground state. The rate for the internal rotation is found to be the highest for the six-membered ring, and this has been interpreted in terms of the partial double bond character of the C-N bond. The results of the experiments seem to indicate that inversion of the amino nitrogen plays the most important role in determining the fluorescence efficiency of the systems.