2-heptadecyl-2-oxazoline | 24041-12-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑啉类
• 英文名称: 2-heptadecyl-2-oxazoline
• 英文别名: 2-heptadecyl-4,5-dihydro-oxazole；2-(n-Heptadecyl)-Δ²-oxazolin；n-Heptadecyl-Δ²-oxazolin；2-heptadecyl-4,5-dihydro-1,3-oxazole
• CAS: 24041-12-1
• 化学式: C₂₀H₃₉NO
• 分子量: 309.536
• InChiKey: GIGOAOBKJCQHSF-UHFFFAOYSA-N

物化性质

• 熔点：
  52-53 °C
• 沸点：
  208 °C(Press: 0.007 Torr)
• 密度：
  0.92±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  8.2
• 重原子数：
  22
• 可旋转键数：
  16
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.95
• 拓扑面积：
  21.6
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  十八烷腈 以23.79 g (77%)的产率得到2-heptadecyl-2-oxazoline
  参考文献：
  名称：

  Compositions and method comprising heterocyclic compounds containing two

  摘要：

  一种用于通过人类和动物的皮肤和粘膜经皮途径给予生理活性药物的方法和组合物，可以用于全身用途或局部用途的经皮装置或制剂，包括将所述生理活性药物和非毒性、有效的渗透增强化合物的混合物涂抹在该皮肤或膜上，所述渗透增强化合物具有结构式I：##STR1## 其中：R是具有5至19个碳原子的饱和或不饱和碳氢基团；R'和R"是氢、较低的烷基、三氟甲基、较低的羟基烷基或较低的羟基烷基酯，但R'和R"不能同时为较低的羟基烷基；X为O或NR.sub.1；R.sub.1为氢、较低的烷基、较低的烯基、较低的羟基烷基或较低的羟基烷基酯。

  公开号：

  US04876249A1

文献信息

• Synthesis of 2-oxazolines via boron esters of N-(2-hydroxyethyl) amides
  作者：Baris Ilkgul、Deniz Gunes、Okan Sirkecioglu、Niyazi Bicak

  DOI：10.1016/j.tetlet.2010.07.167

  日期：2010.10

  process is presented for the synthesis of 2-oxazolines in high yields (75–94%) via boron esters of N-(2-hydroxyethyl) amides. The procedure involves thermolysis of the boron esters at 240–260 °C, in the presence of solid CaO as an acid scavenger and allows the preparation of oxazolines from hydroxyethyl amides of aliphatic and aromatic monocarboxylic acids.

  提出了一种新的便捷的一锅法，该方法通过N-（2-羟乙基）酰胺的硼酸酯以高收率（75-94％）合成2-恶唑啉。该方法包括在固态CaO作为除酸剂的情况下，在240–260°C下将硼酸酯热解，并允许由脂肪族和芳香族单羧酸的羟乙基酰胺制备恶唑啉。
• COMPOSITIONS AND METHODS FOR THE MODULATION OF SPECIFIC AMIDASES FOR N-ACYLETHANOLAMINES FOR USE IN THE THERAPY OF INFLAMMATORY DISEASES
  申请人：Della Valle Francesco

  公开号：US20150057269A1

  公开（公告）日：2015-02-26

  The present invention regards compositions and methods for the modulation of amidases capable of hydrolysing N-acylethanolamines useable in the therapy of inflammatory diseases. In particular, the present invention regards a compound of general formula (I): enantiomers, diastereoisomers, racemes and mixtures, polymorphs, salts, solvates thereof, wherein: (a) R is a linear alkyl radical having 13 to 19 carbon atoms or alkenyl radical having 13 to 19 carbon atoms carrying a double bond; (b) X is 0 or S; (c) Y is a 2 or 3 carbon atom alkylene residue, optionally substituted with one or two groups equal or different from each other and selected from among the group consisting of: —CH 3 , —CH 2 OH, —COOCH 3 , —COOH. Y may preferably be: —CH 2 —CH 2 —, —CH 2 —CH 2 —CH 2 —, CH(CH 3 )—CH 2 —, —CH 2 —CH(CH 3 )—, —CH 2 —C(CH 3 ) 2 —, —CH 2 —CH(CH 2 OH)—, —CH 2 —C((CH 2 OH) 2 )—, —CH═CH—, —CH 2 —CH(COOCH 3 )—, —CH 2 —CH(COOH)—, for use as a medicine.

  本发明涉及用于调节能够水解N-酰乙醇胺的酰胺酶的组合物和方法，用于治疗炎症性疾病。具体来说，本发明涉及一般式(I)的化合物：对映体、非对映异构体、消旋体和混合物、多形态、盐、溶剂化合物，其中：(a) R是具有13至19个碳原子的直链烷基基团或具有13至19个碳原子并带有一个双键的烯基基团；(b) X为0或S；(c) Y为2或3个碳原子的烷基烃基残基，可选择地取代一个或两个相等或不同的基团，所述基团选自以下群组中的一种：—CH3、— OH、—COO 、—COOH。Y可能更倾向于是：—CH2— —、— — — —、CH( )— —、— —CH( )—、— —C( )2—、— —CH( OH)—、— —C(( OH)2—、—CH═CH—、— —CH(COO )—、— —CH(COOH)—，用作药物。
• Gas separation membranes from polymers containing a hydrocarbon backbone
  申请人：The Dow Chemical Company

  公开号：US04695295A1

  公开（公告）日：1987-09-22

  The invention relates to improved gas separation membranes fabricated from cyclic iminoether modified alpha-olefin/carboxylic acid copolymers. The modified membranes possess improved gas selectivities and/or permeabilities over the unmodified membranes. The membranes may be used to separate gas mixtures containing such gases as oxygen, nitrogen, methane, and carbon dioxide.

  本发明涉及由环状亚氨基醚改性的α-烯烃/羧酸共聚物制备的改进型气体分离膜。改性膜具有比未改性膜更好的气体选择性和/或渗透性。该膜可用于分离含氧、氮、甲烷和二氧化碳等气体的气体混合物。
• RUBBER COMPOSITE
  申请人：Takeda Chemical Industries, Ltd.

  公开号：EP0335980A1

  公开（公告）日：1989-10-11

  A rubber composite comprising polyester fibers as the reinforcing material, wherein a compound having at least one cyclic imino ether group of a specific structure in its molecule is incorporated in a rubber composite except for adhesive-­treated polyester cords. Abstract A rubber composite comprising polyester fibers as the reinforcing material, wherein a compound having at least cyclic imino ether group of a specific structure in its molecule is incorporated in a rubber composite except for adhesive-­treated polyester cords.

  一种由聚酯纤维作为增强材料的橡胶复合材料，其中除粘合剂处理过的聚酯帘线外，在橡胶复合材料中加入了一种在其分子中具有至少一个特定结构的环状亚氨基醚基团的化合物。 摘要 一种由聚酯纤维作为增强材料的橡胶复合材料，其中一种在其分子中至少含有一个特定结构的环状亚氨基醚基团的化合物被掺入橡胶复合材料中，但经粘合剂处理的聚酯帘线除外。
• Modified silicone containing hair cosmetic
  申请人：KAO CORPORATION

  公开号：EP0524612A2

  公开（公告）日：1993-01-27

  A hair cosmetic is disclosed, which comprises the following components (a) and (b): (a) a poly(N-acylalkyleneimine)-modified silicone having a poly(N-acylalkyleneimine) segment and an organopolysiloxane segment at a weight ratio of said poly(N-acylalkyleneimine) segment to said organopolysiloxane segment of from 1/20 to 20/1, and having a molecular weight of from 500 to 500,000, wherein said poly(N-acylalkyleneimine) segment comprises a repeating unit represented by the following formula (I): wherein R1 represents a hydrogen atom, an alkyl group having 1 to 22 carbon atoms, a cycloalkyl group having 3 to 22 carbon atoms, an aralkyl group having 7 to 22 carbon atoms or an aryl group having 6 to 22 carbon atoms; and n is 2 or 3; and (b) a film-forming polymer. The hair cosmetic of the present invention is effective in imparting a natural gloss, smoothness, flexibility, smooth-combing properties and water repellency to the hair without deteriorating the hair setting retention function.

  本发明公开了一种头发化妆品，由以下成分（a）和（b）组成： (a) 聚(N-酰基亚烷基亚胺)改性硅氧烷，具有聚(N-酰基亚烷基亚胺)段和有机聚硅氧烷段，所述聚(N-酰基亚烷基亚胺)段与所述有机聚硅氧烷段的重量比为 1/20 至 20/1，分子量为 500 至 500,000，其中所述聚(N-酰基亚烷基亚胺)段包括下式(I)所代表的重复单元： 其中 R1 代表氢原子、具有 1 至 22 个碳原子的烷基、具有 3 至 22 个碳原子的环烷基、具有 7 至 22 个碳原子的芳基或具有 6 至 22 个碳原子的芳基；且 n 为 2 或 3；以及 (b) 成膜聚合物。本发明的护发化妆品能有效地赋予头发自然光泽、顺滑度、柔韧性、梳理顺畅性和防水性，而不会降低头发的定型功能。