(E)-5,6-dimethoxy-2-{3-[(piperidin-1-yl)methyl]-benzylidene}-2,3-dihydroinden-1-one | 1119280-79-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: (E)-5,6-dimethoxy-2-{3-[(piperidin-1-yl)methyl]-benzylidene}-2,3-dihydroinden-1-one
• 英文别名: (2E)-5,6-dimethoxy-2-[[3-(piperidin-1-ylmethyl)phenyl]methylidene]-3H-inden-1-one
• CAS: 1119280-79-3
• 化学式: C₂₄H₂₇NO₃
• 分子量: 377.483
• InChiKey: YUVGMQGHHQRBBC-UDWIEESQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  28
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  38.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  (E)-5,6-dimethoxy-2-{3-[(piperidin-1-yl)methyl]-benzylidene}-2,3-dihydroinden-1-one 在 5% Pd/C 、 氢气 作用下， 以 四氢呋喃 为溶剂， 反应 6.0h， 以84.4%的产率得到5,6-dimethoxy-2-{3-[(piperidin-1-yl)methyl]-benzyl}-2,3-dihydroinden-1-one
  参考文献：
  名称：

  Design, synthesis and AChE inhibitory activity of indanone and aurone derivatives

  摘要：

  A new series of indanone and aurone derivatives have been synthesized and tested for in vitro AChE inhibitory activity by modified Ellman method. Most of them exhibit AChE inhibitory activities superior to rivastigmine. Further, the most potent compound 1g was selected to evaluate the effect on the acquisition and memory impairment by mice step-down passive avoidance test. (C) 2008 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2008.03.003
• 作为产物：
  描述：

  5,6-二甲氧基茚酮 、 3-甲基哌啶苯甲醛 在 氢氧化钾 作用下， 以 甲醇 为溶剂， 反应 3.0h， 以84.9%的产率得到(E)-5,6-dimethoxy-2-{3-[(piperidin-1-yl)methyl]-benzylidene}-2,3-dihydroinden-1-one
  参考文献：
  名称：

  Design, synthesis and AChE inhibitory activity of indanone and aurone derivatives

  摘要：

  A new series of indanone and aurone derivatives have been synthesized and tested for in vitro AChE inhibitory activity by modified Ellman method. Most of them exhibit AChE inhibitory activities superior to rivastigmine. Further, the most potent compound 1g was selected to evaluate the effect on the acquisition and memory impairment by mice step-down passive avoidance test. (C) 2008 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2008.03.003

文献信息

• Design, synthesis and AChE inhibitory activity of indanone and aurone derivatives
  作者：Rong Sheng、Yu Xu、Chunqi Hu、Jing Zhang、Xiao Lin、Jingya Li、Bo Yang、Qiaojun He、Yongzhou Hu

  DOI：10.1016/j.ejmech.2008.03.003

  日期：2009.1

  A new series of indanone and aurone derivatives have been synthesized and tested for in vitro AChE inhibitory activity by modified Ellman method. Most of them exhibit AChE inhibitory activities superior to rivastigmine. Further, the most potent compound 1g was selected to evaluate the effect on the acquisition and memory impairment by mice step-down passive avoidance test. (C) 2008 Elsevier Masson SAS. All rights reserved.