6-hexanoic acid | 135672-64-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: 6-hexanoic acid
• 英文别名: 6-monomethoxytritylaminohexanoic acid；Hexanoic acid, 6-[[(4-methoxyphenyl)diphenylmethyl]amino]-；6-[[(4-methoxyphenyl)-diphenylmethyl]amino]hexanoic acid
• CAS: 135672-64-9
• 化学式: C₂₆H₂₉NO₃
• 分子量: 403.521
• InChiKey: YYZROKUODOUJKO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  30
• 可旋转键数：
  11
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  58.6
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  6-hexanoic acid 在 4-吡咯烷基吡啶 、 N,N'-二环己基碳二亚胺 、 三氟乙酸 作用下， 以 二氯甲烷 为溶剂， 反应 24.17h， 生成 N-(trifluoroacetyl) doxorubicin 14-O-(6'-amino) hexanoate
  参考文献：
  名称：

  Synthesis of New N-(Trifluoroacetyl) Doxorubicin Analogues

  摘要：

  Four new 14-O-acyl derivatives of N-(trifluoroacetyl) doxorubicin possessing a terminal primary amino group have been synthesized in a two steps process under mild reaction conditions.

  DOI：

  10.1080/00397919108019778
• 作为产物：
  描述：

  6-氨基己酸甲酯 盐酸盐 在 lithium hydroxide 、 TEA 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 生成 6-hexanoic acid
  参考文献：
  名称：

  Synthesis and cellular uptake of a fluorescently labeled cyclic PNA-based compound

  摘要：

  A cyclic hexameric PNA-based compound labeled with fluorescein has been prepared following the liquid phase FPB strategy. Its cellular uptake, without and with electroporation, has been investigated by fluorescence microscopy. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2004.06.055

文献信息

• Solid-Phase Synthesis of Positively Charged Deoxynucleic Guanidine (DNG) Tethering a Hoechst 33258 Analogue:  Triplex and Duplex Stabilization by Simultaneous Minor Groove Binding
  作者：Putta Mallikarjuna Reddy、Thomas C. Bruice

  DOI：10.1021/ja031557s

  日期：2004.3.1

  charged guanidine replaces the phosphodiester linkages, tethering to Hoechst 33258 fluorophore by varying lengths has been synthesized. A pentameric thymidine DNG was synthesized on solid phase in the 3' --> 5' direction that allowed stepwise incorporation of straight chain amino acid linkers and a bis-benzimidazole (Hoechst 33258) ligand at the 5'-terminus using PyBOP/HOBt chemistry. The stability

  脱氧核胍 (DNG) 是一种 DNA 类似物，其中带正电荷的胍取代了磷酸二酯键，通过不同长度与 Hoechst 33258 荧光团相连。在固相上以 3' --> 5' 方向合成了五聚体胸苷 DNG，允许使用 PyBOP/HOBt 化学在 5'-末端逐步掺入直链氨基酸接头和双苯并咪唑 (Hoechst 33258) 配体. (DNA)(2).DNG-H 三链体和 DNA.DNG-H 双链体的稳定性由 DNG 和 DNG-Hoechst 33258 (DNG-H) 偶联物​​与 30 聚体双链 (ds) DNA、d(CGCCGCGCGCGCGAAAAACCCGGCGCGCGC) 形成)/d(GCGGCGCGCGCGCTTTTTGGGCCGCGCGCG) 和单链 (ss) DNA，5'-CGCCGCGCGCGCGAAAAACCCGGCGCGCGC-3'，分别通过热熔解和荧光发射实验进行了评估。在
• Synthesis of phosphorodiamidate morpholino oligonucleotides by H-phosphonate method
  作者：Jhuma Bhadra、Jayanta Kundu、Keshab Ch. Ghosh、Surajit Sinha

  DOI：10.1016/j.tetlet.2015.05.080

  日期：2015.7

  Synthesis of T-containing phosphorodiamidate morpholino oligomers (PMO) by H-phosphonate method on solid support has been reported for the first time. Initially, 5-mer then 15-mer of T-containing PMO using H-phosphonate-T monomer was synthesized on polystyrene resin bead. The phosphonamidate backbone was oxidized by iodine–dimethylamine mixture followed by the cleavage from solid support by aqueous

  首次报道了在固体载体上通过H-膦酸酯方法合成含T的二氨基磷酸二酰胺吗啉代低聚物（PMO）。最初，在聚苯乙烯树脂珠上合成了使用H-膦酸酯-T单体的5聚体然后15聚体的含T PMO。碘化二甲胺混合物将膦酰胺的骨架氧化，然后用氨水从固相载体上裂解，得到含15-mer T的PMO。
• Hybridization-triggered fluorescent detection of nucleic acids
  申请人：Epoch Biosciences, Inc.

  公开号：US20030113765A1

  公开（公告）日：2003-06-19

  Compositions and methods for fluorescent detection of nucleic acids are provided. The compositions can be detected by fluorescence when hybridized to a nucleic acid containing a target sequence, but are non-fluorescent in the non-hybridized state. Alternatively, the fluorescence properties of the compositions change in a detectable manner upon hybridization to a nucleic acid containing a target sequence. Methods for synthesis and methods of use of the compositions are also provided.

  本发明提供了用于荧光检测核酸的组合物和方法。这些组合物在与含有目标序列的核酸杂交时可以通过荧光检测，但在非杂交状态下是非荧光的。 或者，这些组合物的荧光特性在与含有目标序列的核酸杂交时以可检测的方式发生变化。还提供了合成和使用这些组合物的方法。
• SMALL MOLECULE CONJUGATES FOR INTRACELLULAR DELIVERY OF NUCLEIC ACIDS
  申请人：F. Hoffmann-La Roche AG

  公开号：EP3147367A1

  公开（公告）日：2017-03-29

  The invention provides use of novel compounds for delivery of nucleic acids, and conjugates of these compounds with nucleic acids. Further novel design criteria for chemically stabilized siRNA particular useful when covalently attached to said compounds and co-administered with a delivery polymer to achieve mRNA knock down in vivo are disclosed therein.

  本发明提供了用于递送核酸的新型化合物，以及这些化合物与核酸的共轭物。此外，本发明还公开了化学稳定 siRNA 的新设计标准，特别是共价连接到上述化合物并与递送聚合物共同给药以实现体内 mRNA 基因敲除。
• BERUBE, G.;RICHARDSON, V. J.;FORD, C. H. J., SYNTH. COMMUN., 21,(1991) N, C. 931-944
  作者：BERUBE, G.、RICHARDSON, V. J.、FORD, C. H. J.

  DOI：——

  日期：——