1-acetylamino-3-(3-hydroxy-[2]naphthoylamino)-benzene | 856059-16-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 1-acetylamino-3-(3-hydroxy-[2]naphthoylamino)-benzene
• 英文别名: 1-Acetylamino-3-(3-hydroxy-[2]naphthoylamino)-benzol；N-(3-acetamidophenyl)-3-hydroxynaphthalene-2-carboxamide
• CAS: 856059-16-0
• 化学式: C₁₉H₁₆N₂O₃
• 分子量: 320.348
• InChiKey: PRLZGGUTGGSEER-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  24
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  78.4
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1-acetylamino-3-(3-hydroxy-[2]naphthoylamino)-benzene 在 五氯化磷 作用下， 以 1,4-二氧六环 为溶剂， 反应 1.0h， 生成 [3-[(3-acetamidophenyl)carbamoyl]naphthalen-2-yl] dihydrogen phosphate
  参考文献：
  名称：

  Fluorescent Substrates for Potential Use in Enzyme-Linked Immunosorbent Assay of Membrane-Bound Nucleic Acids

  摘要：

  A number of phosphorylated fluorochromes were synthesized and tested for the alkaline phosphatase-linked fluorescence assay of membrane-bound nucleic acids. 3-Hydroxy-N-2'-biphenyl-2-naphthalenecarboxamide phosphate ester (HBNP) was found to be the most suitable for the assay. Nonfluorescent HBNP is hydrolyzed by phospholipase bound to the probe DNA to the highly fluorescent 3-hydroxy-N,2'-biphenyl-2-naphthalenecarboxamide (HBN). HBN is insoluble enough in aqueous medium to precipitate on the nylon membrane. Spots containing as little as 5 fg of lambda DNA can be successfully detected on the membrane with HBNP.

  DOI：

  10.1021/ac00080a022
• 作为产物：
  描述：

  间氨基乙酰苯胺 生成 1-acetylamino-3-(3-hydroxy-[2]naphthoylamino)-benzene
  参考文献：
  名称：

  Modena, Ricerca Scientifica, 1956, vol. 26, p. 1451,1460

  摘要：

  DOI：

文献信息

• Fluorescent Substrates for Potential Use in Enzyme-Linked Immunosorbent Assay of Membrane-Bound Nucleic Acids
  作者：Satoshi. Fujita、Masayoshi. Momiyama、Yasumitsu. Kondo、Naoto. Kagiyama、Samuel H. Hori、Takeshi. Toru

  DOI：10.1021/ac00080a022

  日期：1994.4.15

  A number of phosphorylated fluorochromes were synthesized and tested for the alkaline phosphatase-linked fluorescence assay of membrane-bound nucleic acids. 3-Hydroxy-N-2'-biphenyl-2-naphthalenecarboxamide phosphate ester (HBNP) was found to be the most suitable for the assay. Nonfluorescent HBNP is hydrolyzed by phospholipase bound to the probe DNA to the highly fluorescent 3-hydroxy-N,2'-biphenyl-2-naphthalenecarboxamide (HBN). HBN is insoluble enough in aqueous medium to precipitate on the nylon membrane. Spots containing as little as 5 fg of lambda DNA can be successfully detected on the membrane with HBNP.
• Modena, Ricerca Scientifica, 1956, vol. 26, p. 1451,1460
  作者：Modena

  DOI：——

  日期：——