(1-methyl-butyl)-urea | 129459-76-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机碳酸及其衍生物
• 英文名称: (1-methyl-butyl)-urea
• 英文别名: (1-Methyl-butyl)-harnstoff；Pentan-2-ylurea
• CAS: 129459-76-3
• 化学式: C₆H₁₄N₂O
• mdl: MFCD09813343
• 分子量: 130.19
• InChiKey: XZFBXWZJJBVTJD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  9
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.833
• 拓扑面积：
  55.1
• 氢给体数：
  2
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  硝基脲 、 2-氨基戊烷 以 水 为溶剂， 反应 1.0h， 以48%的产率得到(1-methyl-butyl)-urea
  参考文献：
  名称：

  Synthetic anticonvulsants, antihypoxics, and liver monooxygenase system inducers based on amides and urea. XI. Synthesis of alkyl- and arylalkylureas and their effects on the liver monooxygenase system

  摘要：

  DOI：

  10.1007/bf00780583

文献信息

• 2, 6-Dinitrogen-Containing Substituted Purine Derivatives, The Preparation And Uses Thereof
  申请人：Wu Zhanggui

  公开号：US20100144663A1

  公开（公告）日：2010-06-10

  The present invention provides 2,6-dinitrogen-containing substituted purine compounds of formula (A) or salts or solvates thereof or the solvates of salts thereof, as well as pharmaceutical compositions containing such compounds. The compounds of the present invention have the characteristics of lower toxicity, broad anticancer spectrum, higher anticancer activity, good stability and the like. The compounds are useful for the manufacture of an antitumor medicament. The present invention also provides a process for preparing these compounds.

  本发明提供了具有式(A)的2,6-二氮代取代嘌呤化合物或其盐或溶剂合物或其盐的溶剂，以及含有这种化合物的药物组合物。本发明的化合物具有低毒性、广泛的抗癌谱、较高的抗癌活性、良好的稳定性等特点。这些化合物可用于制造抗肿瘤药物。本发明还提供了制备这些化合物的方法。
• 2, 6-Di-Nitrogen-Containing Substituted Purine Derivative, And Preparation Method, Pharmaceutical Composition And Use Thereof
  申请人：ZHEJIANG MEDICINE CO., LTD. XINCHANG PHARMACEUTICAL FACTORY

  公开号：US20160207924A1

  公开（公告）日：2016-07-21

  The present invention provides a 2, 6-di-nitrogen-containing substituted purine derivative having a formula (I) structure, or pharmaceutical salt or hydrate thereof, and preparation method and use thereof. The compound is broad spectrum anticancer, low toxicity, high anticancer activity and good stability.

  本发明提供了一种具有式（I）结构的2,6-二氮含量取代嘌呤衍生物，或其药用盐或水合物，以及其制备方法和用途。该化合物具有广谱抗癌、低毒性、高抗癌活性和良好稳定性。
• Multi-layer application film and method of laminating the same
  申请人：——

  公开号：US20030138635A1

  公开（公告）日：2003-07-24

  A multi-layer application film formed by laminating at least two resin films, a top layer film (I) being formed from a crosslinkable resin coating composition (A), an under layer film (II) being formed from a thermoplastic resin (B), showing practically no stickiness per se, and having a tensile elongation at breakage in the range of 50 to 1000%, said multi-layer application film being applied onto a plastic substrate.

  一种多层涂膜，由至少两层树脂薄膜层压而成，其中表层薄膜（I）由可交联树脂涂层组合物（A）形成，底层薄膜（II）由热塑性树脂（B）形成，薄膜本身几乎没有粘性，断裂时的拉伸伸长率在 50% 到 1000% 之间，所述多层涂膜可涂在塑料基材上。
• Coated film and method of laminating the same
  申请人：——

  公开号：US20030148111A1

  公开（公告）日：2003-08-07

  A multi-layer application film formed by laminating at least two resin films, a top layer film (I) being formed from a crosslinkable resin coating composition (A), an under layer film (II) being formed from a thermoplastic resin (B), showing practically no stickiness per se, and having a tensile elongation at breakage in the range of 50 to 1000%, said multi-layer application film being applied onto a plastic substrate.

  一种多层涂膜，由至少两层树脂薄膜层压而成，其中表层薄膜（I）由可交联树脂涂层组合物（A）形成，底层薄膜（II）由热塑性树脂（B）形成，薄膜本身几乎没有粘性，断裂时的拉伸伸长率在 50% 到 1000% 之间，所述多层涂膜可涂在塑料基材上。
• Functional urethane resin film and laminated film comprising the film
  申请人：——

  公开号：US20030157338A1

  公开（公告）日：2003-08-21

  The present invention relates to a functional urethane resin film formed from a water based urethane resin dispersion (A), showing practically no stickiness per se, anti having a tensile elongation at breakage of 50 to 1000%; and a laminated film by use of the resin film.

  本发明涉及一种由水基聚氨酯树脂分散体（A）形成的功能性聚氨酯树脂薄膜，其本身几乎没有粘性，抗断裂拉伸伸长率为 50%至 1000%；以及一种使用该树脂薄膜的层压薄膜。