(1,2-dimethyl-propyl)-urea | 33034-75-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机碳酸及其衍生物
• 英文名称: (1,2-dimethyl-propyl)-urea
• 英文别名: (α-Methyl-isobutyl)-harnstoff；(1,2-Dimethyl-propyl)-harnstoff；N-(1,2-Dimethyl-propyl)-harnstoff；3-Methylbutan-2-ylurea
• CAS: 33034-75-2
• 化学式: C₆H₁₄N₂O
• mdl: MFCD09661077
• 分子量: 130.19
• InChiKey: YUZXIASGTDHYTR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  9
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.833
• 拓扑面积：
  55.1
• 氢给体数：
  2
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  硝基脲 、 1,2-甲基丙胺 生成 (1,2-dimethyl-propyl)-urea
  参考文献：
  名称：

  Isomeric Amyl Ureas and Derived Barbitals¹

  摘要：

  DOI：

  10.1021/ja01291a025

文献信息

• [EN] TLR2 MODULATOR COMPOUNDS, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF<br/>[FR] COMPOSÉS MODULATEURS DE TLR2, COMPOSITIONS PHARMACEUTIQUES ET LEURS UTILISATIONS
  申请人：AXIAL THERAPEUTICS INC

  公开号：WO2021242923A1

  公开（公告）日：2021-12-02

  The present disclosure relates to compounds which modulate the activity of Toll-like receptor (TLR) proteins, including agonists or activators, partial agonists, and antagonists. Of particular interest of compounds that modulate the activity of TLR2, as well as methods of using such compounds to treat cancer and other disorders associated with a TLR2 pathway.

  本公开涉及调节Toll样受体（TLR）蛋白活性的化合物，包括激动剂或激活剂、部分激动剂和拮抗剂。特别感兴趣的是调节TLR2活性的化合物，以及使用这些化合物治疗与TLR2通路相关的癌症和其他疾病的方法。
• Relationship of the chemical structure of urea derivatives to antispasmodic activity
  作者：A. G. Pechenkin、L. G. Tignibidina、A. P. Gilev、V. K. Gorshkova、V. M. Kurilenko

  DOI：10.1007/bf00771583

  日期：1972.7
• DYNAMIC UREA BONDS FOR POLYMERS
  申请人：THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

  公开号：US20170327627A1

  公开（公告）日：2017-11-16

  The present invention relates to polymers having dynamic urea bonds and more specifically to polymers having hindered urea bonds (HUBs). The present invention also relates to: (a) malleable, repairable, and reprogrammable shape memory polymers having HUBs, (b) reversible or degradable (e.g., via hydrolysis or aminolysis) linear, branched or network polymers having HUBs, and (c) to precursors for incorporation of HUBs into these polymers. The HUB technology can be applied to and integrated into a variety of polymers, such as polyureas, polyurethanes, polyesters, polyamides, polycarbonates, polyamines, and polysaccharides to make linear, branched, and cross-linked polymers. Polymers incorporating the HUBs can be used in a wide variety of applications including plastics, coatings, adhesives, biomedical applications, such as drug delivery systems and tissue engineering, environmentally compatible packaging materials, and 4D printing applications.
• [EN] DYNAMIC UREA BONDS FOR POLYMERS<br/>[FR] LIAISONS URÉE DYNAMIQUES POUR POLYMÈRES
  申请人：UNIV ILLINOIS

  公开号：WO2016069582A1

  公开（公告）日：2016-05-06

  The present invention relates to polymers having dynamic urea bonds and more specifically to polymers having hindered urea bonds (HUBs). The present invention also relates to: (a) malleable, repairable, and reprogrammable shape memory polymers having HUBs, (b) reversible or degradable (e.g., via hydrolysis or aminolysis) linear, branched or network polymers having HUBs, and (c) to precursors for incorporation of HUBs into these polymers. The HUB technology can be applied to and integrated into a variety of polymers, such as polyureas, polyurethanes, polyesters, polyamides, polycarbonates, polyamines, and polysaccharides to make linear, branched, and cross-linked polymers. Polymers incorporating the HUBs can be used in a wide variety of applications including plastics, coatings, adhesives, biomedical applications, such as drug delivery systems and tissue engineering, environmentally compatible packaging materials, and 4D printing applications.
• Isomeric Amyl Ureas and Derived Barbitals¹
  作者：Johannes S. Buck、Axel M. Hjort

  DOI：10.1021/ja01291a025

  日期：1937.12