4-(Acetoxymethyl)-3-methoxy-4-methylnaphthal-2-en-1-one | 142065-63-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 4-(Acetoxymethyl)-3-methoxy-4-methylnaphthal-2-en-1-one
• 英文别名: (2-methoxy-1-methyl-4-oxonaphthalen-1-yl)methyl acetate
• CAS: 142065-63-2
• 化学式: C₁₅H₁₆O₄
• 分子量: 260.29
• InChiKey: JSIPFQANAQZWGJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  19
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  1-(Acetoxymethyl)-2-methoxy-1-methyl-4-(1-(trimethylsilyl)-2-propenyl)-1,4-dihydronaphthalene 在 氧气 、 rose bengal 作用下， 以 甲苯 为溶剂， 以94%的产率得到4-(Acetoxymethyl)-3-methoxy-4-methylnaphthal-2-en-1-one
  参考文献：
  名称：

  A synthesis of various substituted naphthalenones by additions to naphthyloxazolines

  摘要：

  A series of synthetic manipulations on the naphthalene nucleus, containing a 1-(2-oxazolinyl) moiety, is described. Nucleophilic additions afford both regio- and stereoselective products in the 1- and 4-positions. The latter is oxidatively transformed in the 4-keto system 4 which can undergo various substitutions as well as carbonyl transpositions.

  DOI：

  10.1021/jo00041a030

文献信息

• A synthesis of various substituted naphthalenones by additions to naphthyloxazolines
  作者：A. I. Meyers、Thomas G. Gant

  DOI：10.1021/jo00041a030

  日期：1992.7

  A series of synthetic manipulations on the naphthalene nucleus, containing a 1-(2-oxazolinyl) moiety, is described. Nucleophilic additions afford both regio- and stereoselective products in the 1- and 4-positions. The latter is oxidatively transformed in the 4-keto system 4 which can undergo various substitutions as well as carbonyl transpositions.