2,2,6-trimethyl-6-isopropyl-4-oxopiperidine | 151356-86-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 2,2,6-trimethyl-6-isopropyl-4-oxopiperidine
• 英文别名: 2,2,6-Trimethyl-6-propan-2-ylpiperidin-4-one
• CAS: 151356-86-4
• 化学式: C₁₁H₂₁NO
• 分子量: 183.294
• InChiKey: ZBXMSPIJFSLZIP-UHFFFAOYSA-N

物化性质

• 沸点：
  240.0±15.0 °C(Predicted)
• 密度：
  0.881±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.91
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2,2,6-trimethyl-6-isopropyl-4-oxopiperidine 在 sodium tungstate 、 双氧水 、 sodium carbonate 作用下， 以 甲醇 、 水 为溶剂， 反应 22.0h， 以60%的产率得到2,2,6-trimethyl-6-isopropyl-4-oxopiperidine-1-oxyl
  参考文献：
  名称：

  1-alkoxy-polyallkyl-piperidine derivatives and their use as polymerization regulators

  摘要：

  本发明涉及含有结构元素的1-烷氧基-多烷基-哌啶衍生物（I） 其中 G1、G2、G3、G4独立地为C1-C6烷基，但至少有一个不是甲基，或者G1和G2或G3和G4，或者G1和G2和G3和G4一起形成C5-C12环烷基； G5、G6独立地为H、C1-C18烷基、苯基、萘基或COOC1-C18烷基，X代表一个使得从X得到的自由基X能够引发乙烯基不饱和单体聚合的基团，但排除化合物A1和A2 本发明的另一主题是包括a）至少一种乙烯基不饱和单体和b）1-烷氧基-多烷基-哌啶衍生物的可聚合组合物，一种聚合乙烯基不饱和单体的方法，以及1-烷氧基-多烷基-哌啶衍生物用于受控聚合的用途。中间体N-氧基衍生物，N-氧基衍生物与乙烯基不饱和单体的组合物和自由基引发剂X，以及一种聚合方法也是本发明的主题。

  公开号：

  US06353107B1
• 作为产物：
  描述：

  3-甲基-2-丁酮 、 4-甲基-3戊烯-2-酮 在 氨 作用下， 生成 2,2,6-trimethyl-6-isopropyl-4-oxopiperidine
  参考文献：
  名称：

  1-alkoxy-polyallkyl-piperidine derivatives and their use as polymerization regulators

  摘要：

  本发明涉及含有结构元素的1-烷氧基-多烷基-哌啶衍生物（I） 其中 G1、G2、G3、G4独立地为C1-C6烷基，但至少有一个不是甲基，或者G1和G2或G3和G4，或者G1和G2和G3和G4一起形成C5-C12环烷基； G5、G6独立地为H、C1-C18烷基、苯基、萘基或COOC1-C18烷基，X代表一个使得从X得到的自由基X能够引发乙烯基不饱和单体聚合的基团，但排除化合物A1和A2 本发明的另一主题是包括a）至少一种乙烯基不饱和单体和b）1-烷氧基-多烷基-哌啶衍生物的可聚合组合物，一种聚合乙烯基不饱和单体的方法，以及1-烷氧基-多烷基-哌啶衍生物用于受控聚合的用途。中间体N-氧基衍生物，N-氧基衍生物与乙烯基不饱和单体的组合物和自由基引发剂X，以及一种聚合方法也是本发明的主题。

  公开号：

  US06353107B1

文献信息

• 1-Alkoxy-polyalkyl-piperidine derivatives and their use as polymerization regulators
  申请人：Kramer Andreas

  公开号：US20050131177A1

  公开（公告）日：2005-06-16

  The present invention relates to 1-alkoxy-polyalkyipiperidine derivatives containing a structural element of formula (I) G 1 , G 2 , G 3 , G 4 are Independently C 1 -C 6 alkyl with the proviso that at least one is not methyl or G 1 and G 2 or G 3 and G 4 , or G 1 and G 2 and G 3 and G 4 together form a C 5 -C 12 cycloalkyl group; G 5 , G 6 independently are H, C 1 -C 18 alkyl, phenyl, naphthyl or a group COOC 1 -C 18 alkyl and X represents a group such that the free radical Xe derived from X is capable of initiating polymerization of ethylenically unsaturated monomers, with the proviso that compounds A1 and A2 are excluded Further subjects of the invention are a polymerizable composition comprising a) at least one ethylenically unsaturated monomer and b) a 1-alkoxy-polyalkyl-piperidine derivative, a process for polymerizing ethylenically unsaturated monomers, and the use of 1-alkoxy-polyalkyl-piperidine derivatives for controlled polymerization. The intermediate N-oxyl derivatives, a composition of the N-oxyl derivatives with ethylenically unsaturated monomers and a free radical initiator X•, as well as a process for polymerization are also subjects of the present invention.

  本发明涉及一种含有结构元素公式（I）的1-烷氧基-多烷基哌啶衍生物，其中G1、G2、G3、G4独立地为C1-C6烷基，但至少有一个不是甲基，或者G1和G2或G3和G4，或者G1、G2、G3和G4共同形成一个C5-C12环烷基；G5、G6独立地为H、C1-C18烷基、苯基、萘基或COOC1-C18烷基，X代表一种基团，使得来自X的自由基Xe能够引发乙烯基不饱和单体的聚合，但化合物A1和A2被排除在外。本发明的另外几个方面包括：包括a）至少一种乙烯基不饱和单体和b）一种1-烷氧基-多烷基哌啶衍生物的可聚合组合物、聚合乙烯基不饱和单体的方法，以及使用1-烷氧基-多烷基哌啶衍生物进行控制聚合。本发明的中间体N-氧基衍生物、N-氧基衍生物与乙烯基不饱和单体和自由基引发剂X•的组合物，以及聚合的方法也是本发明的内容。
• 1-alkoxy-polyalkyl-piperidine derivatives and their use as polymerization regulators
  申请人：——

  公开号：US20030220423A1

  公开（公告）日：2003-11-27

  The present invention relates to 1-alkoxy-polyalkyl-piperidine derivatives containing a structural element of formula (I) 1 G 1 , G 2 , G 3 , G 4 are independently C 1 -C 6 alkyl with the proviso that at least one is not methyl or G 1 and G 2 or G 3 and G 4 , or G 1 and G 2 and G 3 and G 4 together form a C 5 -C 12 cycloalkyl group; G 5 , G 6 independently are H, C 1 -C 18 alkyl, phenyl, naphthyl or a group COOC 1 -C 18 alkyl and X represents a group such that the free radical X&Circlesolid; derived from X is capable of initiating polymerization of ethylenically unsaturated monomers, with the proviso that compounds A1 and A2 are excluded 2 Further subjects of the invention are a polymerizable composition comprising a) at least one ethylenically unsaturated monomer and b) a 1-alkoxy-polyalkyl-piperidine derivative, a process for polymerizing ethylenically unsaturated monomers, and the use of 1-alkoxy-polyalkyl-piperidine derivatives for controlled polymerization. The intermediate N-oxyl derivatives, a composition of the N-oxyl derivatives with ethylenically unsaturated monomers and a free radical initiator X&Circlesolid;, as well as a process for polymerization are also subjects of the present invention.

  本发明涉及一种含有结构元素(I)1的1-烷氧基-聚烷基-哌啶衍生物，其中G1、G2、G3、G4独立地为C1-C6烷基，但至少其中一个不是甲基，或者G1和G2或G3和G4，或者G1、G2、G3和G4共同形成一个C5-C12环烷基；G5、G6独立地为H、C1-C18烷基、苯基、萘基或一个COOC1-C18烷基基团；X代表一个基团，使得从X衍生的自由基X•能够引发乙烯基不饱和单体的聚合，但化合物A1和A2被排除在外。 本发明的另外几个方面是：包括a)至少一种乙烯基不饱和单体和b)一种1-烷氧基-聚烷基-哌啶衍生物的可聚合组合物；聚合乙烯基不饱和单体的方法；以及使用1-烷氧基-聚烷基-哌啶衍生物进行可控聚合。本发明还涉及中间体N-氧化物衍生物、N-氧化物衍生物与乙烯基不饱和单体的组合物和自由基引发剂X•的聚合方法。
• Oxoammonium salts. 5. A new synthesis of hindered piperidines leading to unsymmetrical TEMPO-type nitroxides. Synthesis and enantioselective oxidations with chiral nitroxides and chiral oxoammonium salts
  作者：Zhenkun Ma、Qingtao Huang、James M. Bobbitt

  DOI：10.1021/jo00070a018

  日期：1993.8

  A new synthesis of unsymmetrical 2,2,6,6-tetraalkyl-4-piperidones from acetonin (2,2,4,4,6-penta-methyl-2,3,4,5-tetrahydropyrimidine) and several ketones is described. When the ketone was a naturally occurring optically active ketone, the piperidones were optically active. The piperidones were converted to unsymmetrical TEMPO-type nitroxides and chiral nitroxides. The optically active nitroxides were used as catalysts for oxidations or converted to chiral oxoammonium salts. The structures of the chiral compounds were determined by 2D H-1 and C-13 NMR, and the cyclic voltammetric properties of the various nitroxides were measured. Several other pyrrolidine oxoammonium salts were prepared, and both types were used as oxidizing agents. Preliminary results of chiral oxidations are presented.
• US6353107B1
  申请人：——

  公开号：US6353107B1

  公开（公告）日：2002-03-05
• US6683142B2
  申请人：——

  公开号：US6683142B2

  公开（公告）日：2004-01-27