5-(6-Fluoroimidazo[1,2-b]pyridazin-2-yl)thiophen-2-amine | 1220909-72-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 噻吩类
• 英文名称: 5-(6-Fluoroimidazo[1,2-b]pyridazin-2-yl)thiophen-2-amine
• 英文别名: 5-(6-fluoroimidazo[1,2-b]pyridazin-2-yl)thiophen-2-amine
• CAS: 1220909-72-7
• 化学式: C₁₀H₇FN₄S
• 分子量: 234.257
• InChiKey: INIMYRURIAMCAQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  16
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  84.4
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  5-(6-Fluoroimidazo[1,2-b]pyridazin-2-yl)thiophen-2-amine 、 碘甲烷 在 sodium hydride 作用下， 以 二甲基亚砜 为溶剂， 反应 1.0h， 以22%的产率得到2-(4'-dimethylaminothiophenyl)-6-fluoroimidazo[1,2-b]pyridazine
  参考文献：
  名称：

  Synthesis and In Vitro Evaluation of Imidazo[1,2-b]pyridazines as Ligands for β-Amyloid Plaques

  摘要：

  A series of imidazo[1,2-b]pyridazine derivatives were synthesized and evaluated for binding to amyloid plaques in vitro using synthetic aggregates of A beta(1-40). Binding affinities of these compounds were found to range from 11.0 to > 1000 nM, depending on the various substitution patterns in the 6-position and 2-position. 2 -(4'-Dimethylaminophenyl)-6-(methylthio)imidazo[1,2-b]pyridazine (4) showed high binding affinity (K(i) = 11.0 nM) and might be useful for the development of novel positron emission tomography radiotracers for imaging A beta plaques.

  DOI：

  10.1021/ml100005j
• 作为产物：
  描述：

  6-fluoro-2-(5-nitrothiophen-2-yl)imidazo[1,2-b]pyridazine 在 盐酸 、 tin(II) chloride dihdyrate 作用下， 以 乙醇 为溶剂， 反应 1.0h， 以57%的产率得到5-(6-Fluoroimidazo[1,2-b]pyridazin-2-yl)thiophen-2-amine
  参考文献：
  名称：

  Synthesis and In Vitro Evaluation of Imidazo[1,2-b]pyridazines as Ligands for β-Amyloid Plaques

  摘要：

  A series of imidazo[1,2-b]pyridazine derivatives were synthesized and evaluated for binding to amyloid plaques in vitro using synthetic aggregates of A beta(1-40). Binding affinities of these compounds were found to range from 11.0 to > 1000 nM, depending on the various substitution patterns in the 6-position and 2-position. 2 -(4'-Dimethylaminophenyl)-6-(methylthio)imidazo[1,2-b]pyridazine (4) showed high binding affinity (K(i) = 11.0 nM) and might be useful for the development of novel positron emission tomography radiotracers for imaging A beta plaques.

  DOI：

  10.1021/ml100005j

文献信息

• Synthesis and In Vitro Evaluation of Imidazo[1,2-<i>b</i>]pyridazines as Ligands for β-Amyloid Plaques
  作者：Fanxing Zeng、David Alagille、Gilles D. Tamagnan、Brian J. Ciliax、Allan I. Levey、Mark M. Goodman

  DOI：10.1021/ml100005j

  日期：2010.5.13

  A series of imidazo[1,2-b]pyridazine derivatives were synthesized and evaluated for binding to amyloid plaques in vitro using synthetic aggregates of A beta(1-40). Binding affinities of these compounds were found to range from 11.0 to > 1000 nM, depending on the various substitution patterns in the 6-position and 2-position. 2 -(4'-Dimethylaminophenyl)-6-(methylthio)imidazo[1,2-b]pyridazine (4) showed high binding affinity (K(i) = 11.0 nM) and might be useful for the development of novel positron emission tomography radiotracers for imaging A beta plaques.