(3-Hydroxybenzyl) phenyl ketone | 29955-31-5

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: (3-Hydroxybenzyl) phenyl ketone
• 英文别名: 3'-hydroxy-deoxybenzoin；3'-Hydroxy-desoxybenzoin；3'-Hydroxydesoxybenzoin；2-(3-Hydroxyphenyl)-1-phenylethanone
• CAS: 29955-31-5
• 化学式: C₁₄H₁₂O₂
• 分子量: 212.248
• InChiKey: KMHUHLXPZJBPIG-UHFFFAOYSA-N

物化性质

• 沸点：
  386.9±17.0 °C(Predicted)
• 密度：
  1.178±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 生成 (3-Hydroxybenzyl) phenyl ketone
  参考文献：
  名称：

  Linnell; Sharma, Quarterly Journal of Pharmacy and Pharmacology, 1941, vol. 14, p. 259,268

  摘要：

  DOI：

文献信息

• Chemical compounds
  申请人：Adams Leroy Jerry

  公开号：US20050004142A1

  公开（公告）日：2005-01-06

  Furo- and thienopyrimidine derivatives, which are useful as TIE-2 and/or VEGFR-2 inhibitors are described herein. The described invention also includes methods of making such furo- and thienopyrimidine derivatives as well as methods of using the same in the treatment of hyperproliferative diseases.

  本文描述了作为TIE-2和/或VEGFR-2抑制剂有用的呋喃和噻吩嘧啶衍生物。所述发明还包括制备这种呋喃和噻吩嘧啶衍生物的方法，以及使用它们治疗增殖过度性疾病的方法。
• 4-AMINO-2,3-DISUBSTITUTED THIENO [2,3,D]PYRIMIDINES AND PHARMACEUTICAL COMPOSITIONS THEREOF
  申请人：Adams Jerry Leroy

  公开号：US20080287466A1

  公开（公告）日：2008-11-20

  Furo- and thienopyrimidine derivatives, which are useful as TIE-2 and/or VEGFR-2 inhibitors are described herein. The described invention also includes methods of making such furo- and thienopyrimidine derivatives as well as methods of using the same in the treatment of hyperproliferative diseases.

  本文描述了作为TIE-2和/或VEGFR-2抑制剂有用的呋喃和噻唑嘧啶衍生物。所述发明还包括制备这种呋喃和噻唑嘧啶衍生物的方法以及使用它们治疗增生性疾病的方法。
• Process for the preparation of arylalkylamines and substituted arylalkylamines
  申请人：HOECHST CELANESE CORPORATION

  公开号：EP0481705A1

  公开（公告）日：1992-04-22

  Arylalkylamines (as a sulfate salt) e.g. tyramine sulfate, are prepared by reacting substituted or unsubstituted arylalkylketones with a lower alkylnitrite in the presence of hydrogen chloride in a dipolar aprotic solvent, then combining the reaction mixture with water and extracting it with a lower alkyl ester or alcohol to recover an aryl-α-oximinoalkylketone extract. The extract, combined with a supported hydrogenation catalyst (e.g. palladium on carbon) in a nonaqueous reaction medium of a major proportion of a mildly protic carboxylic acid (e.g. acetic acid) and a minor proportion of a srong inorganic acid (e.g. sulfuric acid), which is effective in the presence of the catalyst for secondary alcohol dehydration and active as an absorbant for water produced in the dehydration reaction, is hydrogenated to produce the arylalkylamine sulfate sale.

  芳烷基胺（作为硫酸盐），例如硫酸酪胺，是通过在氯化氢存在下，在二极性非 普罗溶剂中，使取代或未取代的芳烷基酮与低级亚硝酸烷基酯反应，然后将反应混 合物与水混合，并用低级烷基酯或醇萃取，以回收芳基-α-氧亚氨基烷基酮萃取物。该萃取物与支撑氢化催化剂（如碳上钯）在非水反应介质中结合，该反应介质主要成分为轻度质子羧酸（如乙酸），次要成分为强无机酸（如硫酸），在催化剂存在下，强无机酸对二次醇脱水有效，对脱水反应中产生的水有吸附作用，氢化反应生成出售的芳基烷基胺硫酸盐。
• Aromatic compounds from furanics
  申请人：Nederlandse Organisatie voor toegepast-natuurwetenschappelijk onderzoek TNO

  公开号：US10562875B2

  公开（公告）日：2020-02-18

  Described are methods for preparing phenols, benzene carboxylic acids, esters and anhydrides thereof from furanic compounds by reaction with a dienophile, wherein the furanic compounds are reacted with a hydrazine and/or oxime and then reacted with a dienophile.

  描述了通过与亲二烯反应从呋喃化合物制备苯酚、苯羧酸、其酯和酸酐的方法，其中呋喃化合物与肼和/或肟反应，然后与亲二烯反应。
• Effect of ring substitution on the photochemistry of .alpha.-(aryloxy)acetophenones
  作者：J. C. Netto-Ferreira、I. G. J. Avellar、J. C. Scaiano

  DOI：10.1021/jo00288a019

  日期：1990.1