methyl N-[cyclohexyl-(2-hydroxynaphthalen-1-yl)methyl]carbamate | 1246299-41-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: methyl N-[cyclohexyl-(2-hydroxynaphthalen-1-yl)methyl]carbamate
• CAS: 1246299-41-1
• 化学式: C₁₉H₂₃NO₃
• 分子量: 313.397
• InChiKey: UHXFBSMXBSZORO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  58.6
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  氨基甲酸甲酯 、 2-萘酚 、 环己烷基甲醛 在 4-imidazol-1-ylbutane-1-sulfonic acid 作用下， 反应 0.42h， 以74%的产率得到methyl N-[cyclohexyl-(2-hydroxynaphthalen-1-yl)methyl]carbamate
  参考文献：
  名称：

  Zwitterionic-type molten salt: An efficient mild organocatalyst for synthesis of 2-amidoalkyl and 2-carbamatoalkyl naphthols

  摘要：

  A green, general, and efficient method has been developed for the synthesis of 2-amidoalkyl and 2-carbamatoalkyl naphthol derivatives through a one-pot three-component condensation of 2-naphthol, aldehydes and amide or carbamates in the presence of zwitterionic-type molten salt as mild organocatalyst under solvent-free conditions. (C) 2010 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.catcom.2010.06.001

文献信息

• Zwitterionic-type molten salt: An efficient mild organocatalyst for synthesis of 2-amidoalkyl and 2-carbamatoalkyl naphthols
  作者：Dhiman Kundu、Adinath Majee、Alakananda Hajra

  DOI：10.1016/j.catcom.2010.06.001

  日期：2010.8

  A green, general, and efficient method has been developed for the synthesis of 2-amidoalkyl and 2-carbamatoalkyl naphthol derivatives through a one-pot three-component condensation of 2-naphthol, aldehydes and amide or carbamates in the presence of zwitterionic-type molten salt as mild organocatalyst under solvent-free conditions. (C) 2010 Elsevier B.V. All rights reserved.