6-O-tritylsucrose | 30694-56-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: 6-O-tritylsucrose
• 英文别名: 6-Mono-O-tritylsaccharose；Trt(-6)Glc(a1-2b)Fruf；(2R,3R,4S,5S,6R)-2-[(2S,3S,4S,5R)-3,4-dihydroxy-2,5-bis(hydroxymethyl)oxolan-2-yl]oxy-6-(trityloxymethyl)oxane-3,4,5-triol
• CAS: 30694-56-5
• 化学式: C₃₁H₃₆O₁₁
• 分子量: 584.62
• InChiKey: UTQVHMMCFUFXHE-MITUGFPZSA-N

物化性质

• 沸点：
  805.3±65.0 °C(Predicted)
• 密度：
  1.48±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  42
• 可旋转键数：
  10
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  179
• 氢给体数：
  7
• 氢受体数：
  11

反应信息

• 作为反应物：
  描述：

  6-O-tritylsucrose 、 苯甲酰氯 反应 12.0h， 生成 hepta-O-benzoyl-6-O-tritylsucrose
  参考文献：
  名称：

  6-脱氧-6-氟蔗糖的合成及其对亮粘菌和链球菌D-葡聚糖的抑制作用。

  摘要：

  DOI：

  10.1016/0008-6215(88)85061-4
• 作为产物：
  描述：

  2,3,1',3',4',6'-hexa-O-benzoylsucrose 、 三苯基氯甲烷 以 吡啶 为溶剂， 反应 60.0h， 生成 6-O-tritylsucrose
  参考文献：
  名称：

  6-脱氧-6-氟蔗糖的合成及其对亮粘菌和链球菌D-葡聚糖的抑制作用。

  摘要：

  DOI：

  10.1016/0008-6215(88)85061-4

文献信息

• Process to Prepare Sucralose
  申请人：Rajadhyaksha Mangesh

  公开号：US20100184969A1

  公开（公告）日：2010-07-22

  The present invention relates to a process to prepare sucralose. More particularly the said process relates to the production of sucralose, chemically known as, 6-Dichloro-1,6-dideoxy-β-D-fructofuranosyl-4-chloro-4-deoxy-alpha-D-galactopyranoside of formula (1)

  本发明涉及一种制备三氯蔗糖的方法。更具体地说，该方法涉及生产三氯蔗糖，化学上称为6-二氯-1,6-二去氧-β-D-果糖呋喃甙-4-氯-4-去氧-α-D-半乳糖苷，化学式为(1)。
• Oxidation periodique de derive´s du saccharose
  作者：Agne`s Badel、Ge´rard Descotes、Julio Mentech

  DOI：10.1016/0008-6215(90)80150-2

  日期：1990.9

  The periodate oxidation of some derivatives of sucrose at primary positions is generally selective for the D-glucopyranoside group. A cleavage at C-2-C3 or C-3-C-4 positions was observed for the 6,1',6'-tri-O-trityl and 6,1',6'-tri-O-(tert-butyldemethylsilyl) derivatives, respectively. The periodate oxidation was more complete for all other derivatives with a cleavage at C-2-C-3 and C-3-C-4.

  蔗糖的某些衍生物在主要位置的高碘酸盐氧化通常对D-吡喃葡萄糖苷基团具有选择性。对于6,1'，6'-tri-O-三苯甲基和6,1'，6'-tri-O-（叔-丁基脱甲基甲硅烷基）衍生物。对于所有其他衍生物而言，高碘酸盐的氧化更为完全，在C-2-C-3和C-3-C-4处有裂解。
• Self-Assembling Properties of 6-<i>O</i>- and 6′-<i>O</i>-Alkylsucrose Mixtures Having Different Chain Lengths Under Aqueous Conditions
  作者：Kouhei Tanaka、Sachie Ohkawabata、Kazuya Yamamoto、Jun-ichi Kadokawa

  DOI：10.1080/07328303.2013.809094

  日期：2013.5.4

  The self-assembling properties of the 6-O- and 6-O-alkylsucrose mixtures with different chain lengths including octyl, decyl, dodecyl, and tetradecyl under aqueous conditions were studied and compared with those of the 6-O- and 6-O-hexadecylsucrose mixture previously reported. The title compounds were synthesized from sucrose in five steps. The results of scanning and transmission electron microscopes, powder X-ray diffraction, and dynamic light scattering measurements indicated that the self-assembling properties of octyl, decyl, and dodecyl derivatives were completely different from those of the 6-O- and 6-O-hexadecylsucrose mixture. The three derivatives reported here primarily formed lamellar planes, which further induced the formation of vesicle-type particles under aqueous conditions, whereas the previous derivatives primarily formed spherical micelles in water, which further assembled according to face-centered cubic organization by a drying process from the aqueous dispersion. It was also found that the 6-O- and 6-O-tetradecylsucrose mixture showed concentration-induced micelle-lamellar transition behavior in an aqueous dispersion. Furthermore, the mixing of a regioisomer, 6-O-hexadecylsucrose, with 6-O-hexadecylsucrose induced different self-assembling properties from that of 6-O-hexadecylsucrose alone, but this effect did not appear in the self-assembling of the 6-O- and 6-O-octylsucrose mixture.
• Self-assembly of 6-O- and 6′-O-hexadecylsucroses mixture under aqueous conditions
  作者：Manami Kanemaru、Shin-ya Kuwahara、Kazuya Yamamoto、Yoshiro Kaneko、Jun-ichi Kadokawa

  DOI：10.1016/j.carres.2010.10.003

  日期：2010.12

  In this paper we report the self-assembly of 6-O- and 6'-O-hexadecylsucroses mixture under aqueous conditions The mixture was synthesized by a five-step sequence from sucrose The SEM image of a sample prepared by drying a dispersion of the mixture in water showed nanoparticles with the diameter of similar to 50 nm and aggregates that were formed by further assembly of them The XRD measurement of the sample exhibited the diffraction pattern assignable to face-centered cubic (FCC) structure and the diameter of a sphere which took part in the FCC structure was calculated to be 5 1 nm This value was relatively close to that observed in the DLS measurement of a dispersion of the mixture in water and estimated for a spherical micelle based on the molecular sizes of the two sucrose ethers On the basis of the above findings the following self-assembly process of the mixture under aqueous conditions was proposed The mixture formed the spherical micelles with the diameter of similar to 5-7 nm in water The micelles regularly organized according to the FCC structure during the drying process from the aqueous dispersion to construct the nanoparticles with the diameter of similar to 50 nm Several numbers of the nanoparticles further assembled to form the aggregates (C) 2010 Elsevier Ltd All rights reserved
• A PROCESS TO PREPARE SUCRALOSE
  申请人：Camlin Fine Chemicals Limited

  公开号：EP1948673A2

  公开（公告）日：2008-07-30