2-[(4,4'-dimethoxytrityl)oxymethyl]-2-methylpropan-3-ol-yl levulinate | 141719-97-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: 2-[(4,4'-dimethoxytrityl)oxymethyl]-2-methylpropan-3-ol-yl levulinate
• 英文别名: [2-[[Bis(4-methoxyphenyl)-phenylmethoxy]methyl]-3-hydroxy-2-methylpropyl] 4-oxopentanoate
• CAS: 141719-97-3
• 化学式: C₃₁H₃₆O₇
• 分子量: 520.623
• InChiKey: LKFFKJKPZFTEIK-UHFFFAOYSA-N

物化性质

• 沸点：
  658.1±55.0 °C(Predicted)
• 密度：
  1.155±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  38
• 可旋转键数：
  15
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  91.3
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  2-[(4,4'-dimethoxytrityl)oxymethyl]-2-methylpropan-3-ol-yl levulinate 、 2-氰乙基N,N-二异丙基氯亚磷酰胺 在 N,N-二异丙基乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 1.5h， 以85%的产率得到2-[(4,4’-dimethoxytrityl)oxymethyl]-2-methylpropan-3-ol-yl levulinate (2-cyanoethyl-N,N-diisopropyl) phoshoramidite
  参考文献：
  名称：

  Modified Galacto‐ or Fuco‐Clusters Exploiting the Siderophore Pathway to Inhibit the LecA‐ or LecB‐Associated Virulence ofPseudomonas aeruginosa

  摘要：

  AbstractGalacto‐ and fuco‐clusters conjugated with one to three catechol or hydroxamate motifs were synthesised to target LecA and LecB lectins of Pseudomonas aeruginosa (PA) localised in the outer membrane and inside the bacterium. The resulting glycocluster–pseudosiderophore conjugates were evaluated as Trojan horses to cross the outer membrane of PA by iron transport. The data suggest that glycoclusters with catechol moieties are able to hijack the iron transport, whereas those with hydroxamates showed strong nonspecific interactions. Mono‐ and tricatechol galactoclusters (G1C and G3C) were evaluated as inhibitors of infection by PA in comparison with the free galactocluster (G0). All of them exhibited an inhibitory effect between 46 to 75 % at 100 μM, with a higher potency than G0. This result shows that LecA localised in the outer membrane of PA is involved in the infection mechanism.

  DOI：

  10.1002/cbic.202000490
• 作为产物：
  描述：

  1,1,1-三(羟甲基)乙烷 在 盐酸 、 4-二甲氨基吡啶 、 对甲苯磺酸 、 三乙胺 、 N,N'-二环己基碳二亚胺 作用下， 以 四氢呋喃 、 甲醇 、 二氯甲烷 、 水 为溶剂， 反应 15.0h， 生成 2-[(4,4'-dimethoxytrityl)oxymethyl]-2-methylpropan-3-ol-yl levulinate
  参考文献：
  名称：

  化合物的制备方法

  摘要：

  本发明公开了一种化合物的制备方法，所述化合物具有如式I所示的结构，其通过化合物II与化合物III在酸/唑类配合物的作用下制备得到中间产物IV的溶液；中间产物IV溶液中加入化合物V，在酸/唑类配合物的作用下制备得到中间产物VI溶液；向中间产物VI的溶液中缓慢加入过氧化丁酮溶液，制得中间产物VII溶液；向中间产物VII的溶液中缓慢加入乙酸肼溶液，制得化合物VIII；化合物VIII在酸/唑类配合物作用下与化合物III反应制得化合物I。

  公开号：

  CN106866748B

文献信息

• BASELESS NUCLEOTIDE ANALOGUES AND USES THEREOF
  申请人：Clinical Micro Sensors, Inc.

  公开号：EP2220102B1

  公开（公告）日：2014-04-16
• US7820391B2
  申请人：——

  公开号：US7820391B2

  公开（公告）日：2010-10-26
• [EN] BASELESS NUCLEOTIDE ANALOGUES AND USES THEREOF<br/>[FR] ANALOGUES DE NUCLÉOTIDE SANS BASE ET LEURS UTILISATIONS
  申请人：OSMETECH MOLECULAR DIAGNOSTICS

  公开号：WO2009061941A2

  公开（公告）日：2009-05-14

  Baseless nucleotide analogs are provided. Said analogs are used in the detection of target nucleic acids. The analogs have formula (I) wherein X is a backbone spacer; S is a solubility moiety; t is 0 or 1; V is a redox active moiety; L1 and L2 are linkers; n = 0 or 1; m = 0 or 1; wherein n + m is at least 1; P1 and P2 are independently selected from the group consisting of hydrogen, phosphoramidite, a protecting group, and a nucleoside containing group, wherein at least one of P1 and P2 is said protecting group or said nucleoside containing group; and q is greater than or equal to 1.
• 化合物的制备方法
  申请人：厦门云凡医药科技有限公司

  公开号：CN106866748B

  公开（公告）日：2018-05-15

  本发明公开了一种化合物的制备方法，所述化合物具有如式I所示的结构，其通过化合物II与化合物III在酸/唑类配合物的作用下制备得到中间产物IV的溶液；中间产物IV溶液中加入化合物V，在酸/唑类配合物的作用下制备得到中间产物VI溶液；向中间产物VI的溶液中缓慢加入过氧化丁酮溶液，制得中间产物VII溶液；向中间产物VII的溶液中缓慢加入乙酸肼溶液，制得化合物VIII；化合物VIII在酸/唑类配合物作用下与化合物III反应制得化合物I。
• Modified Galacto‐ or Fuco‐Clusters Exploiting the Siderophore Pathway to Inhibit the LecA‐ or LecB‐Associated Virulence of<i>Pseudomonas aeruginosa</i>
  作者：Mimouna Madaoui、Olivier Vidal、Albert Meyer、Mathieu Noël、Jean‐Marie Lacroix、Jean‐Jacques Vasseur、Alberto Marra、François Morvan

  DOI：10.1002/cbic.202000490

  日期：2020.12

  AbstractGalacto‐ and fuco‐clusters conjugated with one to three catechol or hydroxamate motifs were synthesised to target LecA and LecB lectins of Pseudomonas aeruginosa (PA) localised in the outer membrane and inside the bacterium. The resulting glycocluster–pseudosiderophore conjugates were evaluated as Trojan horses to cross the outer membrane of PA by iron transport. The data suggest that glycoclusters with catechol moieties are able to hijack the iron transport, whereas those with hydroxamates showed strong nonspecific interactions. Mono‐ and tricatechol galactoclusters (G1C and G3C) were evaluated as inhibitors of infection by PA in comparison with the free galactocluster (G0). All of them exhibited an inhibitory effect between 46 to 75 % at 100 μM, with a higher potency than G0. This result shows that LecA localised in the outer membrane of PA is involved in the infection mechanism.