6-Formyl-naphthalin-1-carbonsaeure | 63409-05-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 6-Formyl-naphthalin-1-carbonsaeure
• 英文别名: 6-Formyl-1-naphthoesaeure；6-Formyl-1-naphthalenecarboxylic acid；6-formylnaphthalene-1-carboxylic acid
• CAS: 63409-05-2
• 化学式: C₁₂H₈O₃
• 分子量: 200.194
• InChiKey: GHYXDWFKORHJNL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  54.4
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• A composition for increasing the anti-cancer activity of an anti-cancer compound
  申请人：OTSUKA PHARMACEUTICAL CO., LTD.

  公开号：EP0180188A2

  公开（公告）日：1986-05-07

  A composition for increasing the anti-cancer activity of an anti-cancer compound selected from among 5-fluorouracil and a compound capable of producing 5-fluorouracil in vivo, the composition comprising an effective amount of a pyridine derivative represented by the formula wherein R1 is hydroxy or acyloxy, R2 and R4 are each hydrogen, halogen, amino, carboxyl, carbamoyl, cyano, nitro, lower alkyl, lower alkenyl or lower alkoxycarbonyl, R3 and R are each hydrogen, hydroxy or acyloxy; when at least one of R1, R3 and R5 is hydroxy, the structure of 1-position on the pyridine rina can be duetothe due to the keto-enol tautomerism, said hydrogen attached to nitrogen being optionally substituted with a substituent selected from the group consisting of lower alkyl, tetrahydrofuranyl, tetrahydropyranyl, lower alkoxy-lower alkyl, phthalidyl, carbamoyl, lower alkoxycarbonyl-lower alkylcarbamoyl, phenyl-lower alkoxy-lower alkyl, phenylcarbamoyl which may have a substituent on the phenyl ring, lower alkylcarbamoyl, carboxy-lower alkylcarbamoyl, lower alkylthio-lower alkyl and lower alkenyl, provided that the compound having the following formula is excluded, wherein a is hydrogen, lower alkyl, tetrahydrofuranyl, tetrahydropyranyl, lower alkoxy-lower alkyl, lower alkylcarbamoyl, lower alkylthio-lower alkyl or lower alkenyl.

  一种提高选自5-氟尿嘧啶和一种能在体内产生5-氟尿嘧啶的化合物的抗癌活性的组合物，该组合物包括有效量的由式表示的吡啶衍生物 其中 R1 是羟基或酰氧基，R2 和 R4 分别是氢、卤素、氨基、羧基、氨基甲酰基、氰基、硝基、低级烷基、低级烯基或低级烷氧基羰基，R3 和 R 分别是氢、羟基或酰氧基；当 R1、R3 和 R5 中至少有一个是羟基时，吡啶里纳上 1 位的结构可以是 当 R1、R3 和 R5 中至少有一个是羟基时，吡啶里纳上 1 位的结构可以是酮烯醇同分异构，所述连接到氮上的氢可选择被选自低烷基、四氢呋喃基、四氢吡喃基、低烷氧基低烷基、邻苯二甲酰基、氨基甲酰基、低烷氧基羰基低烷基氨基甲酰基组成的取代基取代、苯基-低级烷氧基-低级烷基、苯基氨基甲酰基（苯基环上可能有取代基）、低级烷基氨基甲酰基、羧基-低级烷基氨基甲酰基、低级烷硫基-低级烷基和低级烯基，但具有下式的化合物除外、 其中 a 为氢、低级烷基、四氢呋喃基、四氢呋喃基、低级烷氧基低级烷基、低级烷基氨基甲酰基、低级烷硫基低级烷基或低级烯基。
• Production, purification and polymerization of aromatic dicarboxylic acids
  申请人：——

  公开号：US20020173673A1

  公开（公告）日：2002-11-21

  This invention provides a process for purifying the crude aromatic dicarboxylic acids produced by oxidation of dialkyl aromatic hydrocarbons and for using the purified acids in the preparation of polyethylene terephthalate, polyethylene naphthalate and other polyesters. The invention simplifies the manufacturing process by converting the crude aromatic acids into bis-glycol esters in an esterification reactor 4 , from which the esterified partial oxidation impurities present in the oxidation product are removed by distillation in distillation tower 5 . After removal of the volatile impurities, the dicarboxylic acid esters can separated by distillation in distillation tower 6 or by crystallization and converted to polyesters by polycondensation. The volatile impurities reoved as overhead from tower 5 can be recycled as stream 16 to the oxidation reactor where they act as oxidation promoters thereby optionally allowing for a bromine-free oxidation process for dialkyl aromatic hydrocarbons.

  本发明提供了一种工艺，用于纯化通过氧化二烷基芳香烃产生的粗芳香族二羧酸，并将纯化的酸用于制备聚对苯二甲酸乙二醇酯、聚萘二甲酸乙二醇酯和其他聚酯。本发明通过在酯化反应器中将粗芳香族酸转化为双乙二醇酯，简化了生产工艺。 4 通过在蒸馏塔中蒸馏去除氧化产物中存在的酯化部分氧化杂质。 5 .除去挥发性杂质后，二羧酸酯可在蒸馏塔 6 中通过蒸馏分离出来。 6 或进行结晶，然后通过缩聚反应转化为聚酯。从蒸馏塔 5 中去除的挥发性杂质为高空排放。 5 可作为气流 16 进入氧化反应器，在那里作为氧化促进剂，从而可以选择对二烷基芳香烃进行无溴氧化处理。
• Retroviral protease inhibitors
  申请人：MONSANTO COMPANY

  公开号：EP0735019B1

  公开（公告）日：2000-09-20
• US5155113A
  申请人：——

  公开号：US5155113A

  公开（公告）日：1992-10-13
• US6642407B2
  申请人：——

  公开号：US6642407B2

  公开（公告）日：2003-11-04