disodium;2-N-[4-[(E)-2-[4-[(4-anilino-6-morpholin-4-yl-1,3,5-triazin-2-yl)amino]-2-sulfonatophenyl]ethenyl]-3-sulfonatophenyl]-6-morpholin-4-yl-4-N-phenyl-1,3,5-triazine-2,4-diamine

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: disodium;2-N-[4-[(E)-2-[4-[(4-anilino-6-morpholin-4-yl-1,3,5-triazin-2-yl)amino]-2-sulfonatophenyl]ethenyl]-3-sulfonatophenyl]-6-morpholin-4-yl-4-N-phenyl-1,3,5-triazine-2,4-diamine
• 化学式: C40H38N12Na2O8S2
• 分子量: 924.9
• InChiKey: VUJGKADZTYCLIL-YHPRVSEPSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  -1.31
• 重原子数：
  64
• 可旋转键数：
  12
• 环数：
  8.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  282
• 氢给体数：
  4
• 氢受体数：
  20

ADMET

毒理性

• 眼睛症状

Redness.

Redness.

来源:ILO-WHO International Chemical Safety Cards (ICSCs)

毒理性

• 非人类毒性摘录

FBA-260在40-1000 PPM的饮食中给予，对大鼠连续三代（每代两窝）的生殖性能没有影响。

FBA-260 GIVEN @ 40-1000 PPM IN DIET, HAD NO EFFECT ON REPRODUCTIVE PERFORMANCE OF RATS THROUGH 3 SUCCESSIVE 2-LITTER GENERATIONS.

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 非人类毒性摘录

当以40、200或1000 ppm的剂量给大鼠喂食TINOPAL AMS 2年，以及以2000 ppm的剂量给狗喂食2年时，没有出现显著的不良影响。

NO SIGNIFICANT ADVERSE EFFECTS WHEN TINOPAL AMS WAS FED FOR 2 YR TO RATS @ LEVELS OF 40, 200 OR 1000 PPM & FED TO DOGS @ LEVELS OF 2000 PPM FOR 2 YR.

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 非人类毒性摘录

FBA-260在给予小鼠口服5000毫克/公斤的剂量时，在显性致死试验中没有显示出致突变性。

FBA-260 SHOWED NO MUTAGENICITY IN DOMINANT LETHAL TESTS WHEN GIVEN @ 5000 MG/KG, ORALLY, TO MICE.

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 非人类毒性摘录

无毛小鼠在经过数月每日紫外线、可见光和红外线照射后产生了皮肤肿瘤。事先使用TINOPAL AMS处理并未产生光毒性或增强光致癌作用。

SKIN TUMORS WERE PRODUCED IN HAIRLESS MICE AFTER SEVERAL MONTHS DAILY EXPOSURE TO UV, VISIBLE & IR IRRADIATION. PRETREATMENT WITH TINOPAL AMS DID NOT PRODUCE PHOTOTOXICITY OR ENHANCE PHOTOCARCINOGENESIS.

来源:Hazardous Substances Data Bank (HSDB)

吸收、分配和排泄

在大鼠中进行插管实验表明，从肠道吸收很少。迅速通过粪便排出。对大鼠进行静脉注射，迅速通过粪便排出；组织和器官中有少量。皮肤吸收：轻微。

INTUBATION IN RATS SHOWED LITTLE ABSORPTION FROM INTESTINAL TRACT. EXCRETED RAPIDLY IN FECES. PARENTERAL ADMIN TO RATS, RAPIDLY EXCRETED IN FECES; SMALL AMT IN TISSUES & ORGANS. ABSORPTION BY SKIN: SLIGHT.

来源:Hazardous Substances Data Bank (HSDB)

吸收、分配和排泄

口服5毫克/千克（14）C-丁哌卡林给大鼠，药物迅速且完全排出。大部分通过粪便排出。在给药后96小时内，血液、肝脏、肾脏、大脑、肌肉或脂肪中未发现放射性。

ORAL DOSES OF 5 MG/KG (14)C-TINOPAL AMS TO RATS HAD RAPID & COMPLETE EXCRETION. MOST EXCRETION WAS VIA FECES. NO RADIOACTIVITY WAS FOUND IN BLOOD, LIVER, KIDNEY, BRAIN, MUSCLE OR FAT 96 HR AFTER DOSING.

来源:Hazardous Substances Data Bank (HSDB)

反应信息

• 作为反应物：
  描述：

  disodium;2-N-[4-[(E)-2-[4-[(4-anilino-6-morpholin-4-yl-1,3,5-triazin-2-yl)amino]-2-sulfonatophenyl]ethenyl]-3-sulfonatophenyl]-6-morpholin-4-yl-4-N-phenyl-1,3,5-triazine-2,4-diamine 生成 sodium;5-[(4-anilino-6-morpholin-4-yl-1,3,5-triazin-2-yl)amino]-2-formylbenzenesulfonate
  参考文献：
  名称：

  摘要：

  DOI：
• 作为产物：
  描述：

  三聚氯氰 、 苯胺 、 吗啉 生成 disodium;2-N-[4-[(E)-2-[4-[(4-anilino-6-morpholin-4-yl-1,3,5-triazin-2-yl)amino]-2-sulfonatophenyl]ethenyl]-3-sulfonatophenyl]-6-morpholin-4-yl-4-N-phenyl-1,3,5-triazine-2,4-diamine
  参考文献：
  名称：

  NOLL, BERND;KIPPING, WOLFGANG;RASCHKE, DIETER;KRAUSS. E, HERBERT;KEIL, SI+

  摘要：

  DOI：

文献信息

• LEUCO COLORANTS WITH EXTENDED CONJUGATION AS BLUING AGENTS IN LAUNDRY CARE FORMULATIONS
  申请人：The Procter & Gamble Company

  公开号：US20190112557A1

  公开（公告）日：2019-04-18

  A laundry care composition including (a) at least one laundry care ingredient and (b) a compound of Formula (XL) A method of treating a textile comprises the steps of (a) providing such a laundry care composition; (b) adding the laundry care composition to a liquid medium; (c) placing textile articles in the liquid medium; (d) optionally, rinsing the textile; and (e) drying the textile articles.

  一种包括（a）至少一种洗衣护理成分和（b）化合物Formula（XL）的洗衣护理组合物。处理纺织品的方法包括以下步骤：（a）提供这种洗衣护理组合物；（b）将洗衣护理组合物加入液体介质；（c）将纺织品放入液体介质中；（d）可选地，冲洗纺织品；和（e）干燥纺织品。
• Laundry Care Composition Comprising Carboxylate Dye
  申请人：Milliken & Company

  公开号：US20150080561A1

  公开（公告）日：2015-03-19

  The present invention relates to laundry care compositions comprising carboxylate dyes. The laundry care compositions can be laundry detergent compositions, laundry additive compositions such as fabric enhancer compositions or bleach additive compositions. Preferably, the laundry care composition is a laundry detergent composition. The composition can be a solid, such as a powder, tablet or bar, or a liquid. The composition can be in the form of a unit dose, such as pouch. Suitable unit dose pouches include single compartment and multi-compartment pouches.

  本发明涉及包含羧酸盐染料的洗涤护理组合物。洗涤护理组合物可以是洗涤剂组合物，洗涤添加剂组合物，如织物增良剂组合物或漂白剂添加剂组合物。最好，洗涤护理组合物是洗涤剂组合物。该组合物可以是固体，如粉末、片剂或条形，也可以是液体。该组合物可以是单剂形式，如袋装。适用的单剂袋包括单隔室和多隔室袋。
• REACTIVE LEUCO COMPOUNDS AND COMPOSITIONS COMPRISING THE SAME
  申请人：The Procter & Gamble Company

  公开号：US20180119069A1

  公开（公告）日：2018-05-03

  A leuco composition comprises at least one reactive leuco compound, which reactive leuco compound comprises a leuco moiety and at least one reactive moiety covalently bound to the leuco moiety. A laundry care composition comprises a laundry care ingredient and a leuco composition. A method of treating a textile comprises the steps of (i) treating a textile with an aqueous solution containing a leuco composition, (ii) optionally, rinsing the textile, and (iii) drying the textile.

  一种白变色组合物包括至少一种反应性白变色化合物，该反应性白变色化合物包括一个白变色基团和至少一个与白变色基团共价结合的反应性基团。一种洗涤护理组合物包括洗涤护理成分和白变色组合物。一种处理纺织品的方法包括以下步骤：(i)用含有白变色组合物的水溶液处理纺织品，(ii)可选地，冲洗纺织品，(iii)干燥纺织品。
• [EN] LEUCO COLORANTS AND COMPOSITIONS<br/>[FR] COLORANTS ET COMPOSITIONS LEUCO
  申请人：MILLIKEN & CO

  公开号：WO2019075228A1

  公开（公告）日：2019-04-18

  A leuco composition comprises at least one leuco compound, the leuco compound comprising a leuco moiety and a polyalkyleneoxy moiety covalently bound to the leuco moiety. The polyalkyleneoxy moiety comprises at least one ethylene oxide group and at least one propylene oxide group. A laundry care composition comprises (a) at least one laundry care ingredient and (b) a leuco composition as described above. A method of treating a textile includes the steps of (a) providing such a laundry care composition; (b) adding the laundry care composition to a liquid medium; (c) placing textile articles in the liquid medium; (d) optionally, rinsing the textile; and (e) drying the textile articles.

  一种白色组合物包括至少一种白色化合物，该白色化合物包括白色基团和共价结合在白色基团上的聚烷氧基团。聚烷氧基团包括至少一个乙氧基团和至少一个丙氧基团。一种洗涤保养组合物包括（a）至少一种洗涤保养成分和（b）如上所述的白色组合物。一种处理纺织品的方法包括以下步骤：（a）提供这样的洗涤保养组合物；（b）将洗涤保养组合物加入液体介质中；（c）将纺织品放入液体介质中；（d）可选地，冲洗纺织品；（e）干燥纺织品。
• LEUCO COMPOUNDS AND COMPOSITIONS COMPRISING THE SAME
  申请人：The Procter & Gamble Company

  公开号：US20190112560A1

  公开（公告）日：2019-04-18

  A laundry care composition including (a) at least one laundry care ingredient and (b) a leuco compound including an antioxidant moiety covalently bonded to a leuco moiety. A method of treating a textile comprises the steps of (a) providing such a laundry care composition; (b) adding the laundry care composition to a liquid medium; (c) placing textile articles in the liquid medium; (d) optionally, rinsing the textile; and (e) drying the textile articles

  一种洗涤保养组合物，包括（a）至少一种洗涤保养成分和（b）一种包括抗氧化剂基团共价键合到亚甲基基团的白色化合物。一种处理纺织品的方法包括以下步骤：（a）提供这种洗涤保养组合物；（b）将洗涤保养组合物加入液体介质中；（c）将纺织品置于液体介质中；（d）可选地，冲洗纺织品；（e）干燥纺织品。