S-methyl ethanethiosulfonate | 2144-05-0

• 分子结构分类: 有机化合物 - 有机硫化合物 - 磺酰类
• 英文名称: S-methyl ethanethiosulfonate
• 英文别名: ethanethiosulfonic acid S-methyl ester；Aethanthiosulfonsaeure-S-methylester；methyl ethanethiosulfonate；Aethanthiosulfonsaeure-S-methylester；Aethanthiosulfonsaeure-methylester；Methyl-ethan-thiosulfonat；1-Methylsulfanylsulfonyl-ethane；1-methylsulfanylsulfonylethane
• CAS: 2144-05-0
• 化学式: C₃H₈O₂S₂
• 分子量: 140.227
• InChiKey: IZTULVYRHDPFPA-UHFFFAOYSA-N

物化性质

• 沸点：
  64-66 °C(Press: 12 Torr)
• 密度：
  1.2840 g/cm3(Temp: 0 °C)
• LogP：
  0.790 (est)

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  7
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  67.8
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  二乙基二硫醚 在 氯 、 溶剂黄146 作用下， 生成 S-methyl ethanethiosulfonate
  参考文献：
  名称：

  Chlorination of Alkyl Disulfides and the Preparation of Thiolsulfonate Esters¹

  摘要：

  DOI：

  10.1021/jo01089a022

文献信息

• Sulfur containing compounds
  申请人：——

  公开号：US20030220524A1

  公开（公告）日：2003-11-27

  This invention is directed to novel and known stufur containing compounds and pharmaceutically acceptable salts thereof that have utility as antifungals and as antiproliferative agents against mammalian cells, in particular cancer cells and most particularly leukemia-derived cells. The invention provides a method for synthesizing certain of the sulfur containing compounds that is more efficient than previously known methods.

  这项发明涉及新颖且已知的含有硫的化合物以及具有抗真菌活性和作为哺乳动物细胞，特别是癌细胞，尤其是白血病来源细胞的抗增殖剂的药用可接受盐。发明提供了一种合成某些含硫化合物的方法，该方法比先前已知的方法更有效。
• Pathways and Substrate Specificity of DMSP Catabolism in Marine Bacteria of the<i>Roseobacter</i>Clade
  作者：Jeroen S. Dickschat、Claudia Zell、Nelson L. Brock

  DOI：10.1002/cbic.200900668

  日期：2010.2.15

  Sulfur cycle: Catabolism of the algal metabolite dimethylsulfoniopropionate (DMSP) by marine bacteria of the Roseobacter clade resulted in the production of MeSH or the climatically relevant Me2S. Feeding of [2H6]DMSP and derivatives led to the production of novel S and Se volatiles, thus giving insight into the substrate specificities of the participating enzymes and the ratio of the two competing

  硫循环：藻类代谢产物二甲基巯基丙酸（DMSP）通过的海洋细菌的分解代谢Roseobacter进化枝导致产生网或气候相关的Me 2的S.饲养[ 2 ħ 6 ] DMSP和导致生产新型S的衍生物和硒挥发物，从而深入了解参与酶的底物特异性和两种竞争途径的比例。
• Antifungal Thiosulfonates: Potency with Some Selectivity
  作者：Felix Jakob Baerlocher、Mark Otto Baerlocher、Crystal Lee Chaulk、Richard Francis Langler、Stephanie Lee MacQuarrie

  DOI：10.1071/ch00030

  日期：——

  A series of thiosulfonates have been prepared and tested against Aspergillus niger and Aspergillus flavus. In general, the thiosulfonates are moderate antifungal agents—more potent than corresponding inactive disulfides and less potent than corresponding very active fungitoxic disulfides. Apair of thiosulfonates show high selectivity, each killing only one kind of fungus.

  一系列硫代亚砜已经制备并对Aspergillus niger和Aspergillus flavus进行了测试。总体而言，这些硫代亚砜是中等抗真菌剂，比相应的无活性二硫化物更有效，但比相应的非常活跃的真菌毒性二硫化物效果较弱。一对硫代亚砜表现出很高的选择性，每种只能杀死一种真菌。
• Boldyrev,B.G. et al., Journal of general chemistry of the USSR, 1961, vol. 31, p. 2238 - 2241
  作者：Boldyrev,B.G. et al.

  DOI：——

  日期：——
• Chlorination of Alkyl Disulfides and the Preparation of Thiolsulfonate Esters¹
  作者：IRWIN B. DOUGLASS、BASIL SAID FARAH

  DOI：10.1021/jo01089a022

  日期：1959.7