8-Benzyl-1-methyl-1-oxido-3,3-diphenyl-8-aza-1-azoniaspiro[4.5]decane | 171858-67-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 8-Benzyl-1-methyl-1-oxido-3,3-diphenyl-8-aza-1-azoniaspiro[4.5]decane
• CAS: 171858-67-6
• 化学式: C₂₈H₃₂N₂O
• 分子量: 412.575
• InChiKey: UMYJMWJEKFMSCM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  31
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  21.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  8-Benzyl-1-methyl-1-oxido-3,3-diphenyl-8-aza-1-azoniaspiro[4.5]decane 在 溶剂黄146 、 锌 作用下， 反应 1.0h， 生成 1-Methyl-3,3-diphenyl-8-(phenylmethyl)-1,8-diazaspiro<4.5>decane
  参考文献：
  名称：

  Reverse Cope elimination reactions. 2. Application to synthesis

  摘要：

  Intramolecular addition of N,N-disubstitute hydroxylamines to unactivated olefins was used to prepare an indolizine, a pyrrolo[2,1-a]isoquinoline, a 1,8-diazaspiro[4.5]decane, a cyclopenta[b]pyrrole, and an isoindoline. A pyrrolizine and a 1-azabicyclo[2.2.1] heptane were synthesized from acyclic precursors by two consecutive reverse Cope elimination reactions.

  DOI：

  10.1021/jo00123a014
• 作为产物：
  描述：

  α,α-Diphenyl-4-pyridinepropanenitrile 在 sodium tetrahydroborate 、 lithium aluminium tetrahydride 、 sodium acetate 、 二异丁基氢化铝 作用下， 以 四氢呋喃 、 乙醇 、 氯仿 、 异丙醇 、 甲苯 为溶剂， 反应 21.67h， 生成 8-Benzyl-1-methyl-1-oxido-3,3-diphenyl-8-aza-1-azoniaspiro[4.5]decane
  参考文献：
  名称：

  Reverse Cope elimination reactions. 2. Application to synthesis

  摘要：

  Intramolecular addition of N,N-disubstitute hydroxylamines to unactivated olefins was used to prepare an indolizine, a pyrrolo[2,1-a]isoquinoline, a 1,8-diazaspiro[4.5]decane, a cyclopenta[b]pyrrole, and an isoindoline. A pyrrolizine and a 1-azabicyclo[2.2.1] heptane were synthesized from acyclic precursors by two consecutive reverse Cope elimination reactions.

  DOI：

  10.1021/jo00123a014

文献信息

• Reverse Cope elimination reactions. 2. Application to synthesis
  作者：Engelbert Ciganek

  DOI：10.1021/jo00123a014

  日期：1995.9

  Intramolecular addition of N,N-disubstitute hydroxylamines to unactivated olefins was used to prepare an indolizine, a pyrrolo[2,1-a]isoquinoline, a 1,8-diazaspiro[4.5]decane, a cyclopenta[b]pyrrole, and an isoindoline. A pyrrolizine and a 1-azabicyclo[2.2.1] heptane were synthesized from acyclic precursors by two consecutive reverse Cope elimination reactions.