(Z)-(3-(butyltellanyl)allyloxy)triiso-propylsilane | 1234421-29-4

• 分子结构分类: 有机化合物 - 有机金属化合物 - 有机类金属化合物
• 英文名称: (Z)-(3-(butyltellanyl)allyloxy)triiso-propylsilane
• 英文别名: (Z)-(3-(butyltellanyl)allyloxy)triisopropylsilane；[(Z)-3-butyltellanylprop-2-enoxy]-tri(propan-2-yl)silane
• CAS: 1234421-29-4
• 化学式: C₁₆H₃₄OSiTe
• 分子量: 398.131
• InChiKey: SCWZDJHEDQFPKW-RAXLEYEMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.61
• 重原子数：
  19
• 可旋转键数：
  10
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  1,2-环氧丁烷 、 (Z)-(3-(butyltellanyl)allyloxy)triiso-propylsilane 在 噻吩 、 正丁基锂 、 copper(l) cyanide 作用下， 以 四氢呋喃 、 正己烷 为溶剂， 反应 5.0h， 生成
  参考文献：
  名称：

  由碲化乙烯合成取代的α，β-不饱和δ-内酯

  摘要：

  描述了一种合成α，β-不饱和δ-内酯的新方法，α-β-不饱和δ-内酯是存在于许多具有有趣生物活性的天然产物中的单元。该方法基于碲化乙烯的使用，并且与使用闭环复分解的方法互补。该序列以良好的总产率进行，并保留了Z-双键的几何形状。

  DOI：

  10.1016/j.tet.2011.02.029
• 作为产物：
  描述：

  二丁基二碲 在 sodium tetrahydroborate 作用下， 以 乙醇 为溶剂， 以85%的产率得到(Z)-(3-(butyltellanyl)allyloxy)triiso-propylsilane
  参考文献：
  名称：

  Synthesis and evaluation of (−)-Massoialactone and analogues as potential anticancer and anti-inflammatory agents

  摘要：

  (-)-马司尼酯内酯是一种从Cryptocalya massoia中分离出的α,β-不饱和δ-内酯，另有五种类似物被成功合成。研究评估了这些内酯的抗增殖和抗炎活性。结果表明，内酯能够模拟其天然来源化合物的核心功能基团，暗示即使结构有显著改变的类似物也可能保留这些生物活性。©2014 Elsevier Masson SAS. 保留所有权利。

  DOI：

  10.1016/j.ejmech.2014.02.013

文献信息

• Stereoselective synthesis and antitumoral activity of Z-enyne pseudoglycosides
  作者：Claudio R. Dantas、Jucleiton J. R. de Freitas、Queila P. S. Barbosa、Gardenia C. G. Militão、Thiago D. S. Silva、Teresinha G. da Silva、Antônio A. S. Paulino、Juliano C. R. Freitas、Roberta A. Oliveira、Paulo H. Menezes

  DOI：10.1039/c6ob00945j

  日期：——

  An efficient approach for the synthesis of Z-1,3-enynes based on the coupling reaction of Z-vinyl tellurides and alkynes containing a pseudoglycoside moiety is described. The products were obtained in good yields via a stereoselective way. Preliminary screening against three tumor cell lines indicated that the synthesized compounds are promising intermediates for the synthesis of an array of more potent

  描述了基于Z-乙烯基碲化物和含有假糖苷部分的炔烃的偶联反应合成Z -1，3-烯炔的有效方法。通过立体选择的方法以高收率获得了产物。对三种肿瘤细胞系的初步筛选表明，合成的化合物是合成更有力的靶结构阵列的有前途的中间体。
• Differentiation and assignment of vinyl telluride regioisomers by ¹ H-¹²⁵ Te <i>g</i> HMBC
  作者：Juliano C. R. Freitas、Dayvson J. Palmeira、Roberta A. Oliveira、Paulo H. Menezes、Ricardo O. Silva

  DOI：10.1002/mrc.3826

  日期：2012.7

  Complete (1) H, (13) C, and (125) Te NMR spectral data for some vinyl tellurides are described. The (1) H-(125) Te gHMBC experiment was used for the complete chemical shift assignment and structure elucidation of a mixture of regioisomers. The assignment ((125) Te NMR) and coupling constants (J(H,H) ) for all regioisomers are described for the first time.

  描述了一些乙烯基碲化物的完整的（1）H，（13）C和（125）Te NMR光谱数据。（1）H-（125）Te gHMBC实验用于区域异构体混合物的完整化学位移分配和结构阐明。首次描述了所有区域异构体的赋值（（125）Te NMR）和偶联常数（J（H，H））。
• Influence of different protecting groups on the regioselectivity of the hydrotelluration reaction of hydroxy alkynes
  作者：Juliana M. Oliveira、Dayvson J. Palmeira、João V. Comasseto、Paulo H. Menezes

  DOI：10.1590/s0103-50532010000200024

  日期：——

  The influence of protecting groups on the synthesis of regio- and stereodefined vinyl tellurides derived from the reaction of BuTeNa and propargylic- or homo-propargylic alcohols showed that TIPS silyl ether is useful as a regiodirecting group. The application of the methodology to the synthesis of a fragment of (+/-)-Seselidiol, a natural product, demonstrated the applicability of the new methodology.
• Synthesis and evaluation of (−)-Massoialactone and analogues as potential anticancer and anti-inflammatory agents
  作者：Maria E.S.B. Barros、Juliano C.R. Freitas、Juliana M. Oliveira、Carlos H.B. da Cruz、Paulo B.N. da Silva、Larissa C.C. de Araújo、Gardenia C.G. Militão、Teresinha G. da Silva、Roberta A. Oliveira、Paulo H. Menezes

  DOI：10.1016/j.ejmech.2014.02.013

  日期：2014.4

  (-)-Massoialactone, an alpha,beta-unsaturated delta-lactone isolated from Cryptocalya massoia, and five analogues were synthesized and their antiproliferative and anti-inflammatory activities were evaluated. The lactones were able to mimic the "core" functional group required for the biological activity of their parent natural compounds suggesting that substantially altered analogues may retain their properties. (C) 2014 Elsevier Masson SAS. All rights reserved.

  (-)-马司尼酯内酯是一种从Cryptocalya massoia中分离出的α,β-不饱和δ-内酯，另有五种类似物被成功合成。研究评估了这些内酯的抗增殖和抗炎活性。结果表明，内酯能够模拟其天然来源化合物的核心功能基团，暗示即使结构有显著改变的类似物也可能保留这些生物活性。©2014 Elsevier Masson SAS. 保留所有权利。
• Synthesis of substituted α,β-unsaturated δ-lactones from vinyl tellurides
  作者：Juliana M. Oliveira、Juliano C. R. Freitas、João Valdir Comasseto、Paulo Henrique Menezes

  DOI：10.1016/j.tet.2011.02.029

  日期：2011.4

  new approach for the synthesis of α,β-unsaturated δ-lactones, a unit present in many natural products with interesting biological activities is described. The approach was based on the use of a vinyl telluride, and it is complementary to the methods using ring-closing metathesis. The sequence was performed in good overall yield with retention of the Z-double bond geometry.

  描述了一种合成α，β-不饱和δ-内酯的新方法，α-β-不饱和δ-内酯是存在于许多具有有趣生物活性的天然产物中的单元。该方法基于碲化乙烯的使用，并且与使用闭环复分解的方法互补。该序列以良好的总产率进行，并保留了Z-双键的几何形状。