perfluoro(N,N-dimethyl-n-propylamine) | 103217-78-3

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 卤代烷
• 英文名称: perfluoro(N,N-dimethyl-n-propylamine)
• 英文别名: perfluoro(N,N-dimethylpropylamine)；F-N,N-dimethyl-N-propylamine；Perfluor-N,N-dimethyl-propylamin；1,1,2,2,3,3,3-Heptafluoro-N,N-bis(trifluoromethyl)propan-1-amine
• CAS: 103217-78-3
• 化学式: C₅F₁₃N
• 分子量: 321.041
• InChiKey: DHRZPDVVADNSCB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  14

反应信息

• 作为反应物：
  描述：

  perfluoro(N,N-dimethyl-n-propylamine) 在 五氯化钼 硫酸 作用下， 反应 24.0h， 以38.6%的产率得到perfluoro(N-methyl,N-n-propylcarbamoyl fluoride)
  参考文献：
  名称：

  通过全氟（N，N-二烷基甲基胺）与发烟硫酸的反应合成全氟（N，N-二烯丙基氨基甲酰氟）

  摘要：

  一种方便的一步制备新的全氟（N，N-二烷基氨基甲酰氟）[二烷基：R f = R'f = C 2 F 5（1b）; R f＝ C 2 F 5，R′f＝ C 3 F 7（2b）；ř ˚F = R' ˚F = NC 3 ˚F 7（图3b）; ř ˚F = NC 3 ˚F 7，R' ˚F = NC 4 ˚F 9（图4b）; ř ˚F = NC 3 ˚F 7，R' ˚F = NC 5F 11（5b）；ř ˚F = R' ˚F = NC 4 ˚F 9 6B; ř ˚F = NC 3 ˚F 7，R' ˚F = CF 3（图7b）; R f＝ nC 4 F 9 R′＝ CF 3（8b）；ř ˚F = NC 5 ˚F 11，R' ˚F = CF 3（9B）]中描述了：全氟对应（N，N-dialkylmethylamines）用发烟硫酸处理。催化剂（HgSO 4和MoCl 5）提高了所得产品的收率和纯度。描述

  DOI：

  10.1016/s0022-1139(00)84155-x
• 作为产物：
  描述：

  Methyl 2-(dimethylamino)butanoate 生成 perfluoro(N,N-dimethyl-n-propylamine)
  参考文献：
  名称：

  ABE, TAKASHI;HAYASHI, EIJI;BABA, HAJIME;FUKAYA, HARUHIKO, J. FLUOR. CHEM., 48,(1990) N, C. 257-279

  摘要：

  DOI：

文献信息

• The electrochemical fluorination of nitrogen-containing carboxylic acids. Fluorination of dimethylamino- or diethylamino-substituted carboxylic acid derivatives
  作者：Takashi Abe、Eiji Hayashi、Hajime Baba、Haruhiko Fukaya

  DOI：10.1016/s0022-1139(00)80438-8

  日期：1990.6

  The electrochemical fluorination of six derivatives of dimethylamino- or diethylamino-substituted carboxylic acids has been conducted. As the main fluorination products, cyclized and cleaved products as well as the desired N-containing perfluoroacid fluorides were formed, and their ratios depended on the chain length and the structure of the starting carboxylic acids, and the nature of the dialkylamino

  已经进行了二甲氨基或二乙氨基取代的羧酸的六种衍生物的电化学氟化。作为主要的氟化产物，形成环化和裂解的产物以及所需的含N的全氟氟化物，它们的比例取决于链长和起始羧酸的结构以及二烷基氨基的性质。通过这项工作，全氟（二甲基氨基-乙酰氟），全氟（二乙基氨基-乙酰氟），全氟（2-二甲基氨基-丙酰氟），全氟（2-二甲基氨基-丁酰氟）和全氟（3-二甲基氨基-丙酰氟）是准备好了。
• The electrochemical fluorination of N-containing carboxylic acids (Part 4). Fluorination of methyl 3-dialkylamino-isobutyrates and methyl 3-dialkylamino-n-butyrates
  作者：Takashi Abe、Haruhiko Fukaya、Eiji Hayashi、Yoshio Hayakawa、Masakazu Nishida、Hajime Baba

  DOI：10.1016/0022-1139(93)03019-i

  日期：1994.2

  Several methyl esters of 3-dialkylamino-substituted n- and isobutyric acids have been subjected to electrochemical fluorination to give the corresponding perfluoroacid fluorides. Dimethyl, diethyl, pyrrolidino, morpholino, piperidino and N-methylpiperazino groups were investigated as dialkylamino substituents. The structure/yield relationship was evaluated both in terms of the structure of the acid and

  3-二烷基氨基取代的正丁酸和异丁酸的几种甲酯已经进行了电化学氟化反应，得到了相应的全氟代氟化物。研究了作为二烷基氨基取代基的二甲基，二乙基，吡咯烷基，吗啉代，哌啶子基和N-甲基哌嗪子基团。分别根据酸的结构和氨基的种类评价了结构/产率关系。由具有异丁酸骨架的甲酯比具有正丁酸基团的甲酯得到的全氟氟化物的收率更高，并且由具有环状氨基的酸得到的无氟氟化物的收率更高。
• Electrochemical fluorination of (N,N-dialkylamino)alcohols
  作者：Takashi Abe、Haruhiko Fukaya、Eiji Hayashi、Taizo Ono、Masakazu Nishida、Irina Soloshonok、Kunio Okuhara

  DOI：10.1016/s0022-1139(99)00053-6

  日期：1999.7

  Series of amino alcohols including 2-(N,N-dialkylamino)ethanols, 3-(N,N-dimethylamino)propanol and 4-(N,N-dimethylamino)butanol were subjected to electrochemical fluorination. In the case of 2-(N,N-dialkylamino)ethanols, the F-(2-N, N-dialkylamino) acetyl fluorides were obtained in fair to good yields. Yields of each target compound were strongly dependent on the kind of the dialkylamino group. Cyclic amines having an N-(2-hydroxylethyl) group afforded the corresponding F-[N-(c-alkylamino)-substituted acetyl fluorides]. Their yields were generally better than those of acyclic analogs. Several 2-(N,N-dialkylamino)ethanols and 3-(N,N-dimethylamino)propanol were converted into the corresponding trimethylsilylethers, aminoalkyl methyl carbonates and bis-aminoalkyl carbonate, respectively, and they were subjected to fluorination for a comparison of the yield with that obtained from that of the parent aminoalcohol. (C) 1999 Elsevier Science S.A. All rights reserved.
• ABE, TAKASHI;HAYASHI, EIJI, J. FLUOR. CHEM., 45,(1989) N, C. 293-311
  作者：ABE, TAKASHI、HAYASHI, EIJI

  DOI：——

  日期：——
• ABE, TAKASHI;HAYASHI, EIJI;BABA, HAJIME;NAGASE, SHUNJI, J. CHEM. SOC. JAP., CHEM. AND IND. CHEM., 1985, N 10, 1980-1987
  作者：ABE, TAKASHI、HAYASHI, EIJI、BABA, HAJIME、NAGASE, SHUNJI

  DOI：——

  日期：——