4--methyl-benzoic acid | 166110-06-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: 4--methyl-benzoic acid
• 英文别名: 4-[Bis(4-methoxyphenyl)methyl]benzoic acid
• CAS: 166110-06-1
• 化学式: C₂₂H₂₀O₄
• 分子量: 348.398
• InChiKey: FCGVERKEGWDGOP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  26
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  55.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  N-羟基丁二酰亚胺 、 4--methyl-benzoic acid 在 吡啶 、 N,N'-二环己基碳二亚胺 作用下， 以 1,4-二氧六环 为溶剂， 以89%的产率得到N-succinimidyl-4--methyl-benzoate
  参考文献：
  名称：

  异双功能三苯甲基衍生物作为连接试剂，可在标记和固定后回收核酸

  摘要：

  描述了在对位5a或间位5b上带有N-羟基琥珀酸基团作为活性酯的两种杂双功能4,4'-二甲氧基三苯甲基衍生物的合成。虽然先前已经通过6个步骤合成了5a，但是本文介绍了这两种化合物的新颖且更有效的4个步骤。所述元化合物5b中提供了更酸不稳定tntyl相比醚键对位衍生物5a中。使用这些化合物作为连接剂，特别是核酸中的生物聚合物可以在标记或固定后通过用弱酸如80％乙酸水溶液处理而容易地回收。

  DOI：

  10.1016/0040-4020(95)00137-w
• 作为产物：
  描述：

  对醛基苯甲酸 、 苯甲醚 在 三甲基氯硅烷 、 bismuth(III) sulfate 作用下， 反应 6.0h， 以79%的产率得到4--methyl-benzoic acid
  参考文献：
  名称：

  羰基化合物与芳醚和苯酚的室温铋催化双芳基化

  摘要：

  使用Bi 2（SO 4）3作为催化剂和TMSCl作为添加剂，在室温下将各种醛，酮和乙缩醛与芳基醚平稳缩合，以良好的收率选择性地提供相应的二芳基甲烷和三芳基甲烷。

  DOI：

  10.1002/cjoc.201300522

文献信息

• Solid phase sequencing of double-stranded nucleic acids
  申请人：Fu Dong-Jing

  公开号：US20060063193A1

  公开（公告）日：2006-03-23

  Methods for detecting target nucleic acid molecules in a sample are provided. The methods involve hybridizing the nucleic acids or nucleic acids which represent complementary or homologous sequences of the target to an array of nucleic acid probes. These probes include a double-stranded portion, a single-stranded portion and a variable sequence within the single-stranded portion, where the single-stranded region of the probes includes a sequence complementary or homologous to a sequence of the target nucleic acid to be detected. The molecular weights of the hybridized nucleic acids of the set are determined by mass spectroscopy, and from the molecular weights of the hybridized probes, the presence of the target nucleic acid is detected by the presence of its sequence in the sample.

  提供了一种检测样本中目标核酸分子的方法。该方法涉及将与目标互补或同源序列的核酸或代表该核酸的核酸与一组核酸探针的阵列杂交。这些探针包括双链部分、单链部分和单链部分内的可变序列，其中探针的单链区域包括与待检测目标核酸序列互补或同源的序列。通过质谱法确定该组杂交核酸的分子量，并从杂交探针的分子量中检测到样本中目标核酸的存在，以及其序列。
• SOLID PHASE SEQUENCING OF BIOPOLYMERS
  申请人：Cantor Charles

  公开号：US20110172111A1

  公开（公告）日：2011-07-14

  This invention relates to methods for detecting and sequencing target nucleic acid sequences, to mass modified nucleic acid probes and arrays of probes useful in these methods, and to kits and systems which contain these probes. Useful methods involve hybridizing the nucleic acids or nucleic acids which represent complementary or homologous sequences of the target to an array of nucleic acid probes. These probes comprise a single-stranded portion, an optional double-stranded portion and a variable sequence within the single-stranded portion. The molecular weights of the hybridized nucleic acids of the set can be determined by mass spectroscopy, and the sequence of the target determined from the molecular weights of the fragments. Nucleic acids whose sequences can be determined include DNA or RNA in biological samples such as patient biopsies and environmental samples. Probes may be fixed to a solid support such as a hybridization chip to facilitate automated molecular weight analysis and identification of the target sequence.

  本发明涉及检测和测序目标核酸序列的方法，以及在这些方法中有用的质量修饰核酸探针和探针阵列，以及包含这些探针的试剂盒和系统。有用的方法涉及将代表目标互补或同源序列的核酸或核酸杂交到核酸探针阵列上。这些探针包括单链部分，可选的双链部分和单链部分内的可变序列。通过质谱法确定集合的杂交核酸的分子量，并从碎片的分子量确定目标的序列。可以确定序列的核酸包括生物样本中的DNA或RNA，例如患者活检和环境样本。探针可以固定在固体支持上，例如杂交芯片上，以便于自动化的分子量分析和目标序列的鉴定。
• Novel therapeutic targets in cancer
  申请人：——

  公开号：US20040166490A1

  公开（公告）日：2004-08-26

  The present invention relates to novel sequences for use in detection, diagnosis and treatment of cancers, especially lymphomas. The invention provides cancer-associated (CA) polynucleotide sequences whose expression is associated with cancer. The present invention provides CA polypeptides associated with cancer that are present on the cell surface and present novel therapeutic targets against cancer. The present invention further provides diagnostic compositions and methods for the detection of cancer. The present invention provides monoclonal and polyclonal antibodies specific for the CA polypeptides. The present invention also provides diagnostic tools and therapeutic compositions and methods for screening, prevention and treatment of cancer.

  本发明涉及用于检测、诊断和治疗癌症，特别是淋巴瘤的新型序列。本发明提供了其表达与癌症相关的癌症相关（CA）多核苷酸序列。本发明提供与癌症相关的 CA 多肽，这些多肽存在于细胞表面，是针对癌症的新型治疗靶点。本发明进一步提供了检测癌症的诊断组合物和方法。本发明提供了针对 CA 多肽的特异性单克隆和多克隆抗体。本发明还提供了用于筛查、预防和治疗癌症的诊断工具和治疗组合物及方法。
• Dual-Reagent Catalysis within Ir−Sn Domain:  Highly Selective Alkylation of Arenes and Heteroarenes with Aromatic Aldehydes
  作者：Susmita Podder、Joyanta Choudhury、Ujjal Kanti Roy、Sujit Roy

  DOI：10.1021/jo062633n

  日期：2007.4.1

  Reactions of arenes and heteroarenes with aromatic aldehydes proceeded smoothly in the presence of a catalytic combination of [Ir(COD)Cl](2)-SnCl4 to afford the corresponding triarylmethane derivatives (TRAMs) in high yields. This 100% TRAM selective transformation is clean and eliminates the use of acid systems.
• Reverse transcription on microarrays
  申请人：——

  公开号：US20040067492A1

  公开（公告）日：2004-04-08

  The present invention provides novel methods for detection of gene. A method for detecting RNA molecules of interest in which oligonucleotide primers uniquely complementary to specific RNA molecules are used as primers for reverse transcribing target RNAs with reverse transcriptase, or any enzyme that possesses reverse transcription activity, is provided. The invention eliminates the need for labeling or converting the target RNA by incorporating detectable labels in the elongation product of reverse transcription of the probe-bound target RNA in the sample.