1,1,2,2,3,3,4,4,5,5-Decafluoro-6-(heptafluoropropyl)-6-(trifluoromethyl)cyclohexane | 73188-76-8

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 卤代烷
• 英文名称: 1,1,2,2,3,3,4,4,5,5-Decafluoro-6-(heptafluoropropyl)-6-(trifluoromethyl)cyclohexane
• 英文别名: 1,1,2,2,3,3,4,4,5,5-decafluoro-6-(1,1,2,2,3,3,3-heptafluoropropyl)-6-(trifluoromethyl)cyclohexane
• CAS: 73188-76-8
• 化学式: C₁₀F₂₀
• 分子量: 500.07
• InChiKey: SXTYPPLQJZRXLD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7
• 重原子数：
  30
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  20

文献信息

• Perfusate for preserving organ to be transplanted and preserving method
  申请人：The Green Cross Corporation

  公开号：EP0033402A1

  公开（公告）日：1981-08-12

  An organ to be transplanted, such as a kidney, can effectively be preserved for an increased period of time by perfusion using a perfusate which is made of a Ringer's solution modified by increasing its potassium ion content to 8-20 meq/liter with a stably emulsified perfluorocarbon compound and dissolved albumin. A preferred concentration of the perfluorocarbon compound, for example perfluorodecalin, is 7.5 to 12.5%(W/V) and that of albumin is 1-8%(W/V) based on the perfusate.

  灌注液是由林格氏溶液改良而成，改良后的林格氏溶液将钾离子含量提高到 8-20 meq/升，并加入了稳定乳化的全氟碳化合物和溶解的白蛋白。全氟碳化合物（例如全氟萘烷）的优选浓度为 7.5-12.5%(W/V)，白蛋白的优选浓度为灌流液的 1-8%(W/V)。
• A nutritive emulsion having oxygen-transporting properties, and process for its preparation
  申请人：Kabi Pharmacia AB

  公开号：EP0220153A1

  公开（公告）日：1987-04-29

  An emulsion of perfluorocarbon compounds in an aqueous system has oxygen transporting properties. By incorpora­tion of fat of animal or vegetable origin and at least one of the amino acids glycine, serine or phenylalanine, or urea in the emulsion, the stability of the emulsion will be increased to a point where it can be sterilized by autoclaving, and have nutritive properties as well. The invention also concerns the preparation of an emulsion stabilized in the above manner.

  全氟碳化合物在水体系中的乳液具有氧气传输特性。通过在乳液中加入动物或植物脂肪以及甘氨酸、丝氨酸或苯丙氨酸中的至少一种氨基酸或尿素，乳液的稳定性将提高到可以通过高压灭菌消毒的程度，并具有营养特性。本发明还涉及以上述方式稳定乳剂的制备。
• Process for rapid thawing and storage of frozen fluorocarbon emulsion, and resultant product
  申请人：ALPHA THERAPEUTIC CORPORATION

  公开号：EP0548601A1

  公开（公告）日：1993-06-30

  A method for rapidly preparing a frozen fluorocarbon emulsion for administration without degradation and having an extended shelf life is disclosed.

  本发明公开了一种快速制备冷冻碳氟化合物乳剂的方法，该乳剂可在不降解的情况下给药，并具有较长的保质期。
• Manufacturing method of artificial organ, hollow fiber membrane, and dialyzer of hollow fiber membrane type
  申请人：TERUMO KABUSHIKI KAISHA

  公开号：EP0923955A2

  公开（公告）日：1999-06-23

  The present invention provides a manufacturing method of an artificial organ comprising a material having a solubility parameter δ of not more than 13 (cal/cm3)1/2, and a microporous membrane having a portion coated with a fat-soluble modifier. The manufacturing method is composed of the steps of: filling micropores of the body fluid treatment membrane with a filling solution, which has no or little solubility with a fat-soluble modifier solution; and coating a portion of the body fluid treatment membrane with the fat-soluble modifier by contacting the fat-soluble modifier solution. This may allow only necessary portion to be coated with the fat-soluble modifier so that a smaller amount of the fat-soluble modifier may be employed.

  本发明提供了一种人造器官的制造方法，该人造器官由溶解度参数δ不大于13（卡/立方厘米）1/2的材料和微孔膜组成，微孔膜的一部分涂有脂溶性改性剂。该制造方法包括以下步骤：用填充溶液填充体液处理膜的微孔，该填充溶液与脂溶性改性剂溶液无溶解性或溶解性很小；通过接触脂溶性改性剂溶液，在体液处理膜的一部分涂上脂溶性改性剂。这样可以只在必要的部分涂上脂溶性改性剂，从而减少脂溶性改性剂的用量。
• OXYGEN-CONTAINING OPHTHALMIC COMPOSITION
  申请人：ROHTO PHARMACEUTICAL CO., LTD.

  公开号：EP1295602A1

  公开（公告）日：2003-03-26

  An oxygen-rich ophthalmic composition characterized in that it comprises oxygen and/or oxygen donor, wherein the amount of oxygen and/or oxygen contained in oxygen donor is 10 mg or above per liter of the ophthalmic composition, or the content of oxygen is at least 90% of the saturated dissolved oxygen, which composition is useful in prevention, alleviation, or treatment of ocular diseases, especially corneal diseases or disorders.

  一种富氧眼科组合物，其特征在于它包含氧气和/或供氧体，其中每升眼科组合物中氧气和/或供氧体所含的氧气量为 10 毫克或以上，或者氧气含量至少为饱和溶解氧的 90%，该组合物可用于预防、缓解或治疗眼部疾病，尤其是角膜疾病或失调。