6,7-diethoxy-1,2,3,4-tetrahydroisoquinoline | 52759-05-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 四氢异喹啉
• 英文名称: 6,7-diethoxy-1,2,3,4-tetrahydroisoquinoline
• CAS: 52759-05-4
• 化学式: C₁₃H₁₉NO₂
• mdl: MFCD07366339
• 分子量: 221.299
• InChiKey: SFFCFYBFMSQXRO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  16
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.538
• 拓扑面积：
  30.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  6,7-diethoxy-1,2,3,4-tetrahydroisoquinoline 在 盐酸 作用下， 以 甲苯 为溶剂， 生成 6,7-Diethoxy-3,4-dihydro-1H-isoquinolin-2-ylamine; hydrochloride
  参考文献：
  名称：

  Andreae, Siegfried; Schmitz, Ernst; Sonnenschein, Helmut, Journal fur praktische Chemie (Leipzig 1954), 1985, vol. 327, # 3, p. 445 - 454

  摘要：

  DOI：

文献信息

• TETRAHYDROISOQUINOLINES AS ANTIMALARIAL AGENTS
  申请人：Aissaoui Hamed

  公开号：US20110281869A1

  公开（公告）日：2011-11-17

  The invention relates to novel tetrahydroisoquinoline derivatives and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including pharmaceutical compositions containing one or more of those compounds and their use as medicaments for the treatment or prevention of protozoal infections, such as especially malaria.

  这项发明涉及新型四氢异喹啉衍生物及其作为药物组合物中活性成分的用途。该发明还涉及相关方面，包括含有其中一种或多种化合物的药物组合物以及它们作为治疗或预防原虫感染的药物，尤其是疟疾的用途。
• [EN] TETRAHYDROISOQUINOLINES AS ANTIMALARIAL AGENTS<br/>[FR] TÉTRAHYDROISOQUINOLÉINES EN TANT QU'AGENTS ANTIPALUDÉENS
  申请人：ACTELION PHARMACEUTICALS LTD

  公开号：WO2009141782A1

  公开（公告）日：2009-11-26

  The invention relates to novel tetrahydroisoquinoline derivatives and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including pharmaceutical compositions containing one or more of those compounds and their use as medicaments for the treatment

  这项发明涉及新型四氢异喹啉衍生物及其在制备药物组合物中作为活性成分的用途。该发明还涉及相关方面，包括含有其中一种或多种化合物的药物组合物以及它们作为治疗药物的用途。
• [EN] MALONAMIDE DERIVATIVES AS GAMMA-SECRETASE INHIBITORS<br/>[FR] DERIVES DE MALONAMIDE UTILISES COMME INHIBITEURS DE LA GAMMA-SECRETASE
  申请人：HOFFMANN LA ROCHE

  公开号：WO2004069826A1

  公开（公告）日：2004-08-19

  The invention relates to malonamide derivatives of formula (IA) or (IB) and to pharmaceutically suitable acid addition salts thereof. The compounds are Ϝ-secretase inhibitors and the related compounds may be useful in the treatment of Alzheimer's disease.

  这项发明涉及公式（IA）或（IB）的马隆酰胺衍生物及其药用适宜的酸盐。这些化合物是Ϝ-分泌酶抑制剂，相关化合物可能在治疗阿尔茨海默病方面有用。
• Receptor Antagonists
  申请人：——

  公开号：US20040110826A1

  公开（公告）日：2004-06-10

  The present invention provides an &agr; 2c -adrenoceptor antagonist comprising, as an active ingredient, a condensed-ring-pyrimidine derivative represented by general formula (I) below or a pharmaceutically acceptable salt thereof useful for treating and/or preventing various diseases induced by hyperactivity of &agr; 2c -adrenoceptor (for example, Parkinson's disease, L-DOPA-induced dyskinesia, tardive dyskinesia and depression) and the like. 1 {wherein p represents an integer of 1 to 3; R 1 represents a substituted or unsubstituted heterocyclic group, substituted or unsubstituted aryl, or the like; R 2 represents —N(—R 4 )(—R 5 ) (wherein R 4 and R 5 are the same or different, and each represents a hydrogen atom, substituted or unsubstituted aralkyl, or the like, or R 4 and R 5 form a substituted or unsubstituted heterocyclic group together with the adjacent nitrogen atom) or the like; and -Q- represents —N═C(—R 7 )— [wherein R 7 represents —N(—R 9 )(—R 10 ) (wherein R 9 and R 10 are the same or different, and each represents substituted or unsubstituted aralkyl, or the like, or R 9 and R 10 form a substituted or unsubstituted heterocyclic group together with the adjacent nitrogen atom) or the like] or the like}

  本发明提供一种α2c-肾上腺素受体拮抗剂，其包括以下通式（I）所代表的紧缩环嘧啶衍生物或其药学上可接受的盐作为活性成分，用于治疗和/或预防由α2c-肾上腺素受体过度活跃引起的各种疾病（例如帕金森病、L-多巴诱导的运动障碍、迟发性运动障碍和抑郁症）等。 其中，p表示1到3的整数； R1代表取代或未取代的杂环基团、取代或未取代的芳基等； R2代表—N(—R4)(—R5)（其中R4和R5相同或不同，每个代表氢原子、取代或未取代的芳基烷基等，或R4和R5与相邻氮原子一起形成取代或未取代的杂环基团）等；以及 -Q-代表—NHC(—R7)— [其中R7代表—N(—R9)(—R10)（其中R9和R10相同或不同，每个代表取代或未取代的芳基烷基等，或R9和R10与相邻氮原子一起形成取代或未取代的杂环基团）等]等。
• Heterocyclic cyclopentyl tetrahydroisoquinoline and tetrahydropyridopyridine modulators of chemokine receptor activity
  申请人：Butora Gabor

  公开号：US20080081803A1

  公开（公告）日：2008-04-03

  The present invention is directed to compounds of the formula I: Wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , X, n and the broken lines are as defined herein which are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of the chemokine receptor CCR-2.

  本发明涉及以下式I的化合物： 其中R1、R2、R3、R4、R5、R6、R7、R8、R9、X、n和虚线如本文所定义，这些化合物可用作趋化因子受体活性的调节剂。特别地，这些化合物可用作趋化因子受体CCR-2的调节剂。