3-triphenylmethoxy-1-chloropropane | 260967-81-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: 3-triphenylmethoxy-1-chloropropane
• 英文别名: 3-chloro-1-trityloxypropane；3-(triphenylmethoxy)-1chloropropane；[3-Chloropropoxy(diphenyl)methyl]benzene
• CAS: 260967-81-5
• 化学式: C₂₂H₂₁ClO
• 分子量: 336.861
• InChiKey: CEAQJEYGUSLDED-UHFFFAOYSA-N

物化性质

• 沸点：
  436.8±40.0 °C(Predicted)
• 密度：
  1.122±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.7
• 重原子数：
  24
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  3-triphenylmethoxy-1-chloropropane 在 氢氧化钾 、 sodium hydride 、 potassium carbonate 作用下， 以 四氢呋喃 、 N,N-二甲基甲酰胺 为溶剂， 反应 168082.67h， 生成 (4S,14S)-(+)-19-[(3-trityloxy)propyloxy]-4,14-dimethyl-3,6,9,12,15-pentaoxa-21-azabicyclo[15.3.1]heneicosa-1(21),17,19-triene
  参考文献：
  名称：

  Chromatographic enantioseparation of racemic α-(1-naphthyl)ethylammonium perchlorate by a Merrifield resin-bound enantiomerically pure chiral dimethylpyridino-18-crown-6 ligand

  摘要：

  Three novel chiral pyridino-18-crown-6 ligands (S,S)-1, (S,S)-2 and (S,S)-3 were prepared and (S,S)-1 was attached to a Merrifield resin. The resulting adsorbent (S,S)-5 was used as a chiral stationary phase in the chromatographic enantioseparation of racemic alpha-(1 -naphthyl)ethylammonium perchlorate. Also, a new chiral pyridono-18-crown-6 ligand (S,S)-6, used for the synthesis of (S,S)-1 and (S,S)-2, was prepared in two different ways. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0957-4166(99)00515-7
• 作为产物：
  描述：

  三苯基氯甲烷 、 3-氯-1-丙醇 在 4-二甲氨基吡啶 、 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 24.0h， 以95%的产率得到3-triphenylmethoxy-1-chloropropane
  参考文献：
  名称：

  Design, synthesis, and characterization of peptide nanostructures having ion channel activity

  摘要：

  We report the synthesis and the functional studies of multiple crown a-helical peptides designed to form artificial ion channels. The approach combines the versatility of solid phase peptide synthesis, the conformational predictability of peptidic molecules, and the solution synthesis of crown ethers with engineerable ion-binding abilities. Several biophysical methods were employed to characterize the activity and the mode of action of these crown peptide nanostructures. The 21 residue peptides bearing six 21-EC-7 turned out to facilitate the translocation of ions in a similar fashion to natural ion channels. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2003.08.037

文献信息

• Gold(I)-Catalyzed Synthesis of Unsymmetrical Ethers Using Alcohols as Alkylating Reagents
  作者：Yongxiang Liu、Xiaoyu Wang、Yanshi Wang、Chuan Du、Hui Shi、Shengfei Jin、Chongguo Jiang、Jianyong Xiao、Maosheng Cheng

  DOI：10.1002/adsc.201401097

  日期：2015.3.23

  microwave‐irradiated alcohol‐protecting strategy based on gold catalysis utilizing benzyl alcohol, tert‐butyl alcohol and triphenylmethanol as alkylating reagents has been developed. This protecting strategy has wide functional group tolerance with satisfactory yields for the majority of the selected alcohols. The mechanism of this transformation was probed with oxygen‐18 isotope labelled alcohols assisted by

  基于苄基醇，叔丁醇和三苯甲醇作为烷基化试剂的金催化的微波辐射醇保护策略已经被开发出来。对于大多数选定的醇，该保护策略具有宽泛的官能团耐受性和令人满意的产率。在GC-MS技术和化学动力学实验的辅助下，用氧18同位素标记的醇探索了这种转变的机理。该策略为有机合成中的苄基，叔丁基和三苯甲基醚的制备提供了一种有效，直接和替代的方法。
• Compositions providing improved functionalization of terminal anions and processes for improved functionalization of terminal anions
  申请人：——

  公开号：US20020010082A1

  公开（公告）日：2002-01-24

  Compositions including one or more anionic polymerization initiators and one or more additives for improving functionalizing efficiency of living polymer anions are disclosed. The present invention also provides compositions including one or more electrophiles and one or more additives for improving functionalizing efficiency of living polymer anions. Novel electrophiles and processes for improving polymer anion functionalization efficiencies are also disclosed.

  本发明公开了包括一种或多种阴离子聚合引发剂和一种或多种添加剂的组合物，用于提高活聚合物阴离子的官能化效率。本发明还提供了包括一种或多种亲电体和一种或多种添加剂的组合物，用于提高活聚合物阴离子的官能化效率。本发明还公开了用于提高聚合物阴离子官能化效率的新型亲电剂和工艺。
• Hetero-telechelic polymers and processes for making same
  申请人：——

  公开号：US20030013827A1

  公开（公告）日：2003-01-16

  Hetero-telechelic polymers having the formula: FG—(Q) d —Z—J—[A(R 1 R 2 R 3 )] x (1) wherein FG is a protected or non-protected functional group; Q is a saturated or unsaturated hydrocarbyl group derived by incorporation of a compound selected from the group consisting of conjugated diene hydrocarbons, alkenylsubstituted aromatic hydrocarbons, and mixtures thereof; d is an integer from 10 to 200; Z is a branched or straight chain hydrocarbon group which contains 3-25 carbon atoms, optionally containing aryl or substituted aryl groups; J is oxygen, sulfur, or nitrogen; [A(R 1 R 2 R 3 )] x is a protecting group, wherein A is an element selected from Group IVa of the Periodic Table of Elements; R 1 , R 2 , and R 3 are each independently selected from the group consisting of hydrogen, alkyl, substituted alkyl groups containing lower alkyl, lower alkylthio, and lower dialkylamino groups, aryl or substituted aryl groups containing lower alkyl, lower alkylthio, and lower dialkylamino groups, and cycloalkyl and substituted cycloalkyl containing 5 to 12 carbon atoms; and x is dependent on the valence of J and varies from one when J is oxygen or sulfur to two when J is nitrogen, with the proviso J and FG are not the same, and processes for making the same.

  具有以下化学式的杂交链烯聚合物 FG-(Q) d -Z-J-[A（R 1 R 2 R 3 )&rsqb； x (1) 其中，FG 是受保护或不受保护的官能团；Q 是饱和或不饱和的烃基，通过加入选自共轭二烯烃、烯基取代的芳香烃及其混合物的化合物而得到；d 是 10 到 200 之间的整数；Z 是含有 3-25 个碳原子的支链或直链烃基，可选择含有芳基或取代的芳基；J 是氧、硫或氮；[A(R 1) 1 R 2 R 3 )&rsqb； x 是保护基团，其中 A 是选自元素周期表第 IVa 族的元素；R 1 , R 2 和 R 3 各自独立地选自氢、烷基、含有低级烷基、低级烷硫基和低级二烷基氨基的取代烷基、含有低级烷基、低级烷硫基和低级二烷基氨基的芳基或取代芳基、以及含有 5 至 12 个碳原子的环烷基和取代环烷基组成的组；且 x 与 J 的价数有关，从 J 为氧或硫时的 1 到 J 为氮时的 2 不等，但 J 和 FG 不相同，以及制造相同物质的工艺。
• EP0746572A4
  申请人：——

  公开号：EP0746572A4

  公开（公告）日：1997-03-26
• NEW FUNCTIONALIZED INITIATORS FOR ANIONIC POLYMERIZATION
  申请人：FMC CORPORATION

  公开号：EP0746572A1

  公开（公告）日：1996-12-11