thiophosphoric acid O-ethyl ester chloride methylamide | 682-90-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机硫代磷酸及其衍生物
• 英文名称: thiophosphoric acid O-ethyl ester chloride methylamide
• 英文别名: Thiophosphorsaeure-O-aethylester-chlorid-methylamid；O-ethyl N-methylphosphoramidochloridothionate；ethyl N-methyl chlorothiophosphoramidate；N-[chloro(ethoxy)phosphinothioyl]methanamine
• CAS: 682-90-6
• 化学式: C₃H₉ClNOPS
• 分子量: 173.603
• InChiKey: QOLACWFHYSUXPZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  8
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  53.4
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  thiophosphoric acid O-ethyl ester chloride methylamide 在 氨 作用下， 以 乙醇 为溶剂， 生成 O-Aethyl-N-methyl-phosphordiamidthioat
  参考文献：
  名称：

  Mel'nikov,N.N. et al., Journal of general chemistry of the USSR, 1970, vol. 40, p. 2199 - 2203

  摘要：

  DOI：

文献信息

• Pyrimidin-4-yl-phosphorus esters and insecticidal, acaricidal or
  申请人：Sumitomo Chemical Company, Limited

  公开号：US04308258A1

  公开（公告）日：1981-12-29

  Pyrimidin-4-yl-phosphorothionates of the formula (I), ##STR1## wherein R is a C.sub.1 -C.sub.2 alkyl group, R.sub.1 is a C.sub.1 -C.sub.2 alkoxyl or C.sub.1 -C.sub.4 alkylamino group, R.sub.2 and R.sub.3, which may be the same or different, are each a halogen atom, a C.sub.1 -C.sub.3 alkoxyl or methylmercapto group, and X is an oxygen or sulfur atom; a process for producing pyrimidin-4-yl-phosphorothionates of the formula (I) characterized by condensing a 4-hydroxypyrimidine of the formula (II), ##STR2## wherein R.sub.2 and R.sub.3, which may be the same or different, are each a halogen atom, a C.sub.1 -C.sub.3 alkoxyl or methylmercapto group, with a halogen compound of the formula, ##STR3## wherein R is a C.sub.1 -C.sub.2 alkyl, R.sub.1 is a C.sub.1 -C.sub.2 alkoxyl or C.sub.1 -C.sub.4 alkylamino group, Y is a halogen atom and X is an oxygen or sulfur atom; an insecticide, acaricide and nematocide characterized by containing pyrimidin-4-yl-phosphorothionates of the formula (I) as an active ingredient; 4-hydroxypyrimidines of the formula (II) wherein R.sub.2 and R.sub.3, which may be the same or different, are each a halogen atom, a C.sub.2 -C.sub.3 alkoxyl or methylmercapto group; and a process for producing 4-hydroxypyrimidines of the formula (II) wherein R.sub.2 and R.sub.3, which may be the same or different, are each a halogen atom, a C.sub.2 -C.sub.3 alkoxyl or methylmercapto group, characterized by reacting an acetamidine hydrochloride of the formula, ##STR4## wherein R.sub.4 is a halogen atom, a C.sub.2 -C.sub.3 alkoxyl or methylmercapto group, with a .beta.-ketoester of the formula, ##STR5## wherein R.sub.5 is a halogen atom, a C.sub.2 -C.sub.3 alkoxyl or methylmercapto group, and R.sub.6 is a C.sub.1 -C.sub.2 alkyl group.

  式(I)的嘧啶-4-基磷氧硫酸酯，其中R是C.sub.1-C.sub.2烷基，R.sub.1是C.sub.1-C.sub.2烷氧基或C.sub.1-C.sub.4烷基氨基，R.sub.2和R.sub.3，可能相同也可能不同，每个都是卤素原子，C.sub.1-C.sub.3烷氧基或甲硫基，X是氧或硫原子；一种生产式(I)的嘧啶-4-基磷氧硫酸酯的方法，其特征在于将式(II)的4-羟基嘧啶与式的卤素化合物进行缩合，其中R是C.sub.1-C.sub.2烷基，R.sub.1是C.sub.1-C.sub.2烷氧基或C.sub.1-C.sub.4烷基氨基，Y是卤素原子，X是氧或硫原子；一种杀虫剂、杀螨剂和杀线虫剂，其特征在于含有式(I)的嘧啶-4-基磷氧硫酸酯作为活性成分；式(II)的4-羟基嘧啶，其中R.sub.2和R.sub.3，可能相同也可能不同，每个都是卤素原子，C.sub.2-C.sub.3烷氧基或甲硫基；以及一种生产式(II)的4-羟基嘧啶的方法，其中R.sub.2和R.sub.3，可能相同也可能不同，每个都是卤素原子，C.sub.2-C.sub.3烷氧基或甲硫基，其特征在于将式的乙酰胍盐与β-酮酯反应。
• DE2212906
  申请人：——

  公开号：——

  公开（公告）日：——
• Lysak, E. I.; Rymareva, T. G.; Khaskin, B. A., Journal of general chemistry of the USSR, 1992, vol. 62, # 8.1, p. 1463 - 1466
  作者：Lysak, E. I.、Rymareva, T. G.、Khaskin, B. A.

  DOI：——

  日期：——
• Mandel'baum,Ya.A. et al., Journal of general chemistry of the USSR, 1967, vol. 37, p. 2417 - 2420
  作者：Mandel'baum,Ya.A. et al.

  DOI：——

  日期：——
• DE2030509
  申请人：——

  公开号：——

  公开（公告）日：——