tert-butyl-3-(ethylaminoformyl)piperidine-1-carboxylate | 937724-98-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: tert-butyl-3-(ethylaminoformyl)piperidine-1-carboxylate
• 英文别名: tert-butyl 3-(ethylcarbamoyl) piperidine-1-carboxylate；Tert-butyl 3-(ethylcarbamoyl)piperidine-1-carboxylate
• CAS: 937724-98-6
• 化学式: C₁₃H₂₄N₂O₃
• 分子量: 256.345
• InChiKey: WSLHXCFQTZFZSR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  18
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.85
• 拓扑面积：
  58.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  tert-butyl-3-(ethylaminoformyl)piperidine-1-carboxylate 在 盐酸 、 硼烷四氢呋喃络合物 、 三乙胺 、 N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate 作用下， 以 四氢呋喃 、 甲醇 、 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 21.17h， 生成 methyl 4-[[3-[[ethyl(1H-indole-2-carbonyl)amino]methyl]piperidin-1-yl]methyl]benzoate
  参考文献：
  名称：

  COMPOUNDS, COMPOSITIONS AND METHODS OF USE AGAINST STRESS GRANULES

  摘要：

  本文描述了与神经退行性疾病、肌肉骨骼疾病、癌症、眼科疾病和病毒感染相关的细胞内包涵体形成和应激颗粒的调节化合物、组合物和方法。

  公开号：

  US20180305334A1
• 作为产物：
  描述：

  3-哌啶甲酸 在 1-羟基苯并三唑 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 作用下， 以 二氯甲烷 为溶剂， 生成 tert-butyl-3-(ethylaminoformyl)piperidine-1-carboxylate
  参考文献：
  名称：

  Quinoxalinylurea derivatives as a novel class of JSP-1 inhibitors

  摘要：

  A series of quinoxalinylurea-based inhibitors are synthesized and shown to be the novel and potent inhibitors against Jnk Stimulatory Phosphatase-1 (JSP-1), which is a special member of dual-specificity protein phosphatase (DSP) family. Biological assay and computational modeling studies showed the compounds were reversible and noncompetitive inhibitors of JSP-1. JSP-1 inhibitors may be useful for the treatment of inflammatory, vascular, neurodegenerative, metabolic, and oncological diseases in humans associated with dysfunctional Jnk signaling. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2007.01.094

文献信息

• Charged ion channel blockers and methods for use
  申请人：Nocion Therapeutics, Inc.

  公开号：US10968179B2

  公开（公告）日：2021-04-06

  The invention provides compounds of Formula (I), or pharmaceutically acceptable salts thereof: The compounds, compositions, methods and kits of the invention are useful for the treatment of pain, itch, and neurogenic inflammation.

  本发明提供了式（I）化合物或其药学上可接受的盐类： 本发明的化合物、组合物、方法和试剂盒可用于治疗疼痛、瘙痒和神经源性炎症。
• CHARGED ION CHANNEL BLOCKERS AND METHODS FOR USE
  申请人：Nocion Therapeutics, Inc.

  公开号：EP3938345A1

  公开（公告）日：2022-01-19
• Charged Ion Channel Blockers and Methods for Use
  申请人：Nocion Therapeutics, Inc.

  公开号：US20200290953A1

  公开（公告）日：2020-09-17

  The invention provides compounds of Formula (I), or pharmaceutically acceptable salts thereof: The compounds, compositions, methods and kits of the invention are useful for the treatment of pain, itch, and neurogenic inflammation.
• [EN] COMPOUNDS, COMPOSITIONS AND METHODS OF USE AGAINST STRESS GRANULES<br/>[FR] COMPOSÉS, COMPOSITIONS ET MÉTHODES D'UTILISATION CONTRE DES GRANULES DE STRESS
  申请人：AQUINNAH PHARMACEUTICALS INC

  公开号：WO2017066705A1

  公开（公告）日：2017-04-20

  Herein, compounds, compositions and methods for modulating inclusion formation and stress granules in cells related to the onset of neurodegenerative diseases, musculoskeletal diseases, cancer, ophthalmological diseases, and viral infections are described.
• [EN] CHARGED ION CHANNEL BLOCKERS AND METHODS FOR USE<br/>[FR] BLOQUEURS DE CANAUX IONIQUES CHARGÉS ET PROCÉDÉS D'UTILISATION
  申请人：NOCION THERAPEUTICS INC

  公开号：WO2020185830A1

  公开（公告）日：2020-09-17

  The invention provides compounds of Formula (I), or pharmaceutically acceptable salts thereof: (I) The compounds, compositions, methods and kits of the invention are useful for the treatment of pain, itch, and neurogenic inflammation.