2-dimethoxymethyl-2-methyl-3,4-epoxy-6-nitro-3,4-dihydro-2H-1-benzopyran | 146821-87-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 2-dimethoxymethyl-2-methyl-3,4-epoxy-6-nitro-3,4-dihydro-2H-1-benzopyran
• 英文别名: 2-(Dimethoxymethyl)-1a,7b-dihydro-2-methyl-6-nitro-2H-oxireno[c][1]benzopyran；2-(dimethoxymethyl)-2-methyl-6-nitro-1a,7b-dihydrooxireno[2,3-c]chromene
• CAS: 146821-87-6
• 化学式: C₁₃H₁₅NO₆
• 分子量: 281.265
• InChiKey: IUCVZCYPEDRIRJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  86
• 氢给体数：
  0
• 氢受体数：
  6

文献信息

• Benzopyran derivatives substituted with a thioxobenzoxazole derivative, pharmaceutically acceptable salts thereof, their preparations and pharmaceutical compositions containingthem
  申请人：Hwang Sun Kyung

  公开号：US20070093481A1

  公开（公告）日：2007-04-26

  The present invention relates to benzopyran derivatives substituted with a thioxobenzoxazole derivative, or pharmaceutically acceptable salts thereof, processes for preparing the same and a pharmaceutical composition containing the above as an effective ingredient Benzopyran derivatives substituted with thioxobenzoxazole derivatives, represented in , have the function of protecting heart from ischemia-reperfusion both in vivo and in vitro, so that a pharmaceutical composition containing benzopyran derivatives substituted with thioxobenzoxoazole derivatives or pharmaceutically acceptable salts thereof of the present invention as an effective ingredient can be effectively used for the protection of tissues influenced by ischemia-reperfusion, for example, for the protection of heart, nervous cells, brain, retinal cells, storage organs, etc, and for the treatment of diseases caused by ischemia-reperfusion.

  本发明涉及一种取代有硫代苯并噁唑衍生物的苯并吡喃衍生物，或其药学上可接受的盐，以及制备它们的方法和包含上述物质作为有效成分的制药组合物。取代有硫代苯并噁唑衍生物的苯并吡喃衍生物，如<公式1>所示，具有在体内和体外保护心脏免受缺血再灌注损伤的功能，因此，本发明的取代有硫代苯并噁唑衍生物的苯并吡喃衍生物或其药学上可接受的盐作为有效成分的制药组合物可以有效用于保护受缺血再灌注影响的组织，例如心脏、神经细胞、大脑、视网膜细胞、储存器官等的保护，以及治疗由缺血再灌注引起的疾病。
• Novel benzopyran derivatives and processes for the preparation thereof
  申请人：KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY

  公开号：EP0514935B1

  公开（公告）日：1995-11-08
• US5236935A
  申请人：——

  公开号：US5236935A

  公开（公告）日：1993-08-17
• US7420060B2
  申请人：——

  公开号：US7420060B2

  公开（公告）日：2008-09-02