2,9-Diethyl-1,10-phenanthroline

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 菲咯啉
• 英文名称: 2,9-Diethyl-1,10-phenanthroline
• 化学式: C₁₆H₁₆N₂
• 分子量: 236.31
• InChiKey: NHJXLNNOSPXXBR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  25.8
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  1,10-菲罗啉 、 乙基锂 以45%的产率得到
  参考文献：
  名称：

  PIJPER, P. J.;GOOT, H. VAN, DER;TIMMERMAN, H.;NAUTA, WIJBE, TH., EUR. J. MED. CHEM., 1984, 19, N 5, 399-404

  摘要：

  DOI：

文献信息

• Synthesis of halichondrin analogs and uses thereof
  申请人：President and Fellows of Harvard College

  公开号：US10556910B2

  公开（公告）日：2020-02-11

  The present invention provides halichondrin analogs, such as compounds of Formula (I). The compounds may bind to microtubule sites, thereby inhibiting microtubule dynamics. Also provided are methods of synthesis, pharmaceutical compositions, kits, methods of treatment, and uses that involve the compounds for treatment of a proliferative disease (e.g., cancer). Compounds of the present invention are particularly useful for the treatment of metastatic breast cancer, non-small cell lung cancer, prostate cancer, and sarcoma. The included methods of synthesis are useful for the preparation of compounds of Formula (I)-(III) along with naturally occurring halicondrins (e.g., halichondrin B & C, norhalichondrin A, B, & C, and homohalichondrin A, B, & C). Also included are methods for interconverting between the halichondrins, norhalichondrins, and homohalichondrins and their unnatural epimers at the C38 ketal stereocenter through the use of an acid-mediated equilibration.

  本发明提供了卤虫菊酯类似物，如式（I）化合物。这些化合物可与微管位点结合，从而抑制微管动力学。本发明还提供了化合物的合成方法、药物组合物、试剂盒、治疗方法以及用于治疗增殖性疾病（如癌症）的用途。本发明的化合物尤其适用于治疗转移性乳腺癌、非小细胞肺癌、前列腺癌和肉瘤。本发明所包含的合成方法可用于制备式（I）-（III）化合物以及天然卤化膦（例如，卤化膦 B 和 C，去卤化膦 A、B 和 C，同卤化膦 A、B 和 C）。此外，还包括通过使用酸介导的平衡，在 C38 酮立体中心实现卤化琼脂、去卤化琼脂和高卤化琼脂及其非天然表聚物之间相互转化的方法。
• NEW COMPOUND, ORGANIC ELECTROLUMINESCENCE DEVICE MATERIAL, ORGANIC ELECTROLUMINESCENCE DEVICE AND ELECTRONIC DEVICE
  申请人：IDEMITSU KOSAN CO., LTD.

  公开号：US20140077191A1

  公开（公告）日：2014-03-20

  A compound is represented by a formula (1) below. In the formula (1), X 1 to X 8 each independently represent a carbon atom to be bonded to a group represented by the following formula (20), CR X or a nitrogen atom. At least one of X 1 to X 8 is a carbon atom to be bonded to the group represented by the following formula (2). R X is each independently a hydrogen atom, a substituted or unsubstituted alkyl group having 1 to 30 carbon atoms, or the like.
• SYNTHESIS OF HALICHONDRIN ANALOGS AND USES THEREOF
  申请人：President and Fellows of Harvard College

  公开号：US20170137437A1

  公开（公告）日：2017-05-18

  The present invention provides halichondrin analogs, such as compounds of Formula (I). The compounds may bind to microtubule sites, thereby inhibiting microtubule dynamics. Also provided are methods of synthesis, pharmaceutical compositions, kits, methods of treatment, and uses that involve the compounds for treatment of a proliferative disease (e.g., cancer). Compounds of the present invention are particularly useful for the treatment of metastatic breast cancer, non-small cell lung cancer, prostate cancer, and sarcoma. The included methods of synthesis are useful for the preparation of compounds of Formula (I)-(III) along with naturally occurring halicondrins (e.g., halichondrin B & C, norhalichondrin A, B, & C, and homohalichondrin A, B, & C). Also included are methods for interconverting between the halichondrins, norhalichondrins, and homohalichondrins and their unnatural epimers at the C38 ketal stereocenter through the use of an acid-mediated equilibration.
• US9871206B2
  申请人：——

  公开号：US9871206B2

  公开（公告）日：2018-01-16
• PIJPER, P. J.;GOOT, H. VAN, DER;TIMMERMAN, H.;NAUTA, WIJBE, TH., EUR. J. MED. CHEM., 1984, 19, N 5, 399-404
  作者：PIJPER, P. J.、GOOT, H. VAN, DER、TIMMERMAN, H.、NAUTA, WIJBE, TH.

  DOI：——

  日期：——