2,2-Dimethyl-6-(4-methylphenyl)imino-3,4-dihydrobenzo[h]chromen-5-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 萘并吡喃类
• 英文名称: 2,2-Dimethyl-6-(4-methylphenyl)imino-3,4-dihydrobenzo[h]chromen-5-one
• 化学式: C₂₂H₂₁NO₂
• 分子量: 331.4
• InChiKey: LOLQUHPYGGOUDO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  25
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  38.7
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• METHODS OF TREATING CANCER COMPRISING TARGETING NQO1
  申请人：The Board of Regents of The University of Texas System

  公开号：EP2619331A1

  公开（公告）日：2013-07-31
• [EN] METHODS OF TREATING CANCER COMPRISING TARGETING NQO1<br/>[FR] MÉTHODES DE TRAITEMENT DU CANCER COMPORTANT LE CIBLAGE DE NQO1
  申请人：UNIV TEXAS

  公开号：WO2012040492A1

  公开（公告）日：2012-03-29

  Disclosed herein are methods for determining whether an individual with cancer is suitable for a treatment with an NQOl bioactivatable drug, predicting responsiveness of an individual with cancer to a treatment with an NQOl bioactivatable drug, and treating an individual with cancer with an NQOl bioactivatable drug composition.
• [EN] COMPOSITIONS AND METHODS FOR THE DELIVERY OF BETA LAPACHONE<br/>[FR] COMPOSITIONS ET PROCÉDÉS D'ADMINISTRATION DE BÊTA-LAPACHONE
  申请人：UNIV TEXAS

  公开号：WO2012040513A1

  公开（公告）日：2012-03-29

  Disclosed herein are methods and micelle compositions for delivering an encapsulated therapeutic agent, such as beta-lapachone, for cancer therapy. Also provided herein are micelle compositions comprising hydrophobic superparamagnetic iron oxide nanoparticles and a beta-lapachone compound encapsulated with the hydrophobic core of the micelle.