1,4,5,6,7,7-Hexachloro-3-(3,4,5-trihydroxy-6-oxoxanthen-9-yl)bicyclo[2.2.1]hept-5-ene-2-carboxylic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 1,4,5,6,7,7-Hexachloro-3-(3,4,5-trihydroxy-6-oxoxanthen-9-yl)bicyclo[2.2.1]hept-5-ene-2-carboxylic acid
• 化学式: C₂₁H₁₀Cl₆O₇
• 分子量: 587.0
• InChiKey: NYRAATDDHGRRNZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  34
• 可旋转键数：
  2
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  124
• 氢给体数：
  4
• 氢受体数：
  7

文献信息

• COMPOSITIONS AND METHODS FOR INHIBITING G PROTEIN SIGNALING
  申请人：University of Rochester

  公开号：EP2147310A2

  公开（公告）日：2010-01-27
• US8975259B2
  申请人：——

  公开号：US8975259B2

  公开（公告）日：2015-03-10
• [EN] COMPOSITIONS AND METHODS FOR INHIBITING G PROTEIN SIGNALING<br/>[FR] COMPOSITIONS ET PROCÉDÉS PERMETTANT D'INHIBER LA SIGNALISATION DE LA PROTÉINE G
  申请人：UNIV ROCHESTER

  公开号：WO2009020677A2

  公开（公告）日：2009-02-12

  A method of identifying an agent which binds to at least one amino acid residue of the protein interaction site of G-protein beta subunit composes contacting a G protein beta subunit with a test agent in the presences of a peptide that binds at least one amino acid residue of the protein interaction site of the beta subunit and determining whether the agent inhibits the binding of the peptide.