2-[(6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-1-yl)methyl]-9,10-dimethoxy-3-phenyl-4,6,7,11b-tetrahydro-1H-benzo[a]quinolizine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 四氢异喹啉
• 英文名称: 2-[(6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-1-yl)methyl]-9,10-dimethoxy-3-phenyl-4,6,7,11b-tetrahydro-1H-benzo[a]quinolizine
• 化学式: C₃₃H₃₈N₂O₄
• 分子量: 526.7
• InChiKey: SKPRLNUWCGPXAF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  39
• 可旋转键数：
  7
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.39
• 拓扑面积：
  52.2
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• Methods for Sensitizing Cancer Cells to Inhibitors
  申请人：Sherman Michael

  公开号：US20090062222A1

  公开（公告）日：2009-03-05

  The present invention is based on the discovery that inactivation of the heat shock response in cancer cells significantly enhances their sensitivity to proteasome and Hsp90 inhibitors. The inventors have discovered novel compounds which exhibit low toxicity, inhibit the heat shock protein response and sensitize cancer cells to anti-cancer therapies. In general, the heat shock protein inhibitors of the present invention share a common structure, namely a 2H-benzo[a]quinolizine tricyclic ring. Also encompassed are methods for a high throughput screen to identify heat shock inhibitors that sensitize cancer cells to anti-cancer therapies.
• [EN] METHODS FOR SENSITIZING CANCER CELLS TO INHIBITORS<br/>[FR] METHODES DE SENSIBILISATION DES CELLULES CANCEREUSES A DES INHIBITEURS
  申请人：UNIV BOSTON

  公开号：WO2007041294A2

  公开（公告）日：2007-04-12

  [EN] The present invention is based on the discovery that inactivation of the heat shock response in cancer cells significantly enhances their sensitivity to proteasome and Hsp90 inhibitors. The inventors have discovered novel compounds which exhibit low toxicity, inhibit the heat shock protein response and sensitize cancer cells to anti- cancer therapies. In general, the heat shock protein inhibitors of the present invention share a common structure, namely a 2H-benzo[a]quinolizine tricyclic ring. Also encompassed are methods for a high throughput screen to identify heat shock inhibitors that sensitize cancer cells to anti-cancer therapies.
  [FR] La présente invention est basée sur la découverte selon laquelle l'inactivation de la réponse à un choc thermique des cellules cancéreuses améliore de manière significative leur sensibilité aux inhibiteurs de protéasome et de Hsp90. L'invention concerne de nouveaux composés présentant une faible toxicité, inhibant la réponse des protéines de choc thermique et sensibilisant les cellules cancéreuses aux thérapies anti-cancéreuses. Les inhibiteurs des protéines de choc thermique de l'invention partagent en général une structure commune, à savoir un noyau tricyclique de 2H-benzo[a]quinolizine. L'invention concerne également des méthodes de criblage à haut rendement permettant d'identifier des inhibiteurs de choc thermique sensibilisant les cellules cancéreuses aux thérapies anti-cancéreuses.